KEGG   ENZYME: 6.3.4.17Help
Entry
EC 6.3.4.17                 Enzyme                                 

Name
formate---dihydrofolate ligase;
formyltransferase, dihydrofolate;
dihydrofolate formyltransferase;
formyl dihydrofolate synthase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
formate:dihydrofolate ligase (ADP-forming)
Reaction(IUBMB)
ATP + formate + dihydrofolate = ADP + phosphate + 10-formyldihydrofolate [RN:R02238]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
formate [CPD:C00058];
dihydrofolate [CPD:C00415]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
10-formyldihydrofolate [CPD:C03204]
Comment
Not identical with EC 6.3.4.3 (formate---tetrahydrofolate ligase).
History
EC 6.3.4.17 created 1992
Reference
1  [PMID:2306274]
  Authors
Drake JC, Baram J, Allegra CJ.
  Title
Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells.
  Journal
Biochem. Pharmacol. 39 (1990) 615-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
123303-25-3

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