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Entry
EC 6.3.4.23                 Enzyme                                 

Name
formate---phosphoribosylaminoimidazolecarboxamide ligase;
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase;
5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase;
purP (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
formate:5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide ligase (ADP-forming)
Reaction(IUBMB)
ATP + formate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = ADP + phosphate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [RN:R06975]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
formate [CPD:C00058];
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [CPD:C04677]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide [CPD:C04734]
Comment
This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyses a step in the synthesis of purine nucleotides. It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3, phosphoribosylaminoimidazolecarboxamide formyltransferase.
History
EC 6.3.4.23 created 2013
Pathway
Purine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
Orthology
K06863  
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase
Genes
PRF: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
GYY_07695(purP)
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMAZ: 
MMJ: 
MMAC: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
Mbur_1029(purP) Mbur_1626(purP)
MMET: 
MMH: 
MHAZ: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MPD: 
MCP_2462(purP-1) MCP_2481(purP-2) MCP_2482(purP-3)
MEZ: 
Mtc_2399(purP)
RCI: 
RCIX2374(purP)
MTH: 
MMG: 
METC: 
MWO: 
MST: 
MSI: 
MRU: 
mru_0595(purP)
MEB: 
Abm4_1385(purP)
MMIL: 
sm9_0511(purP)
MEYE: 
MOL: 
MEL: 
MEW: 
METH: 
MFC: 
BRM9_0147(purP)
MFI: 
MCUB: 
MCBB_2033(purP)
MFV: 
MKA: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
TAR: 
MAX: 
MER: 
MEAR: 
Mpt1_c09180(purP1) Mpt1_c13110(purP2)
MARC: 
PHO: 
PH0324(PH0324) PH1348(PH1348)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
PYC: 
TKO: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
TNU: 
TEU: 
TGY: 
THV: 
TCH: 
TPEP: 
TPIE: 
TCE: 
PPAC: 
SMR: 
IHO: 
IIS: 
DKA: 
DFD: 
IAG: 
PFM: 
PDL: 
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
STK_02890(purP) STK_02900(purP)
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
SULA: 
MSE: 
MCN: 
AHO: 
AMAN: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
PYW: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
FFO: 
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
NCT: 
NMSP_0725(purP_1) NMSP_0856(purP_2)
CSY: 
NGA: 
Ngar_c02760(purP1) Ngar_c27450(purP2)
NVN: 
NVIE_014230(purP1) NVIE_015540(purP2)
NEV: 
TAA: 
CSU: 
NBV: 
TAH: 
NDV: 
NDEV_1117(purP) NDEV_1244(purP)
KCR: 
BARB: 
 » show all
Taxonomy
Reference
1  [PMID:15623504]
  Authors
Ownby K, Xu H, White RH.
  Title
A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis.
  Journal
J. Biol. Chem. 280 (2005) 10881-7.
  Sequence
[mja:MJ_0136]
Reference
2  [PMID:18069798]
  Authors
Zhang Y, White RH, Ealick SE
  Title
Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
  Journal
Biochemistry. 47 (2008) 205-17.
  Sequence
[mja:MJ_0136] [pfu:PF1517]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9032-03-5

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