KEGG   ENZYME: 6.3.4.8Help
Entry
EC 6.3.4.8                  Enzyme                                 

Name
imidazoleacetate---phosphoribosyldiphosphate ligase;
5-phosphoribosylimidazoleacetate synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)
Reaction(IUBMB)
ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate = ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate [RN:R04068]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
imidazole-4-acetate [CPD:C02835];
5-phosphoribosyl diphosphate [CPD:C00119]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
1-(5-phosphoribosyl)imidazole-4-acetate [CPD:C04437];
diphosphate [CPD:C00013]
History
EC 6.3.4.8 created 1972
Pathway
Histidine metabolism
Reference
1  [PMID:14235540]
  Authors
CROWLEY GM.
  Title
THE ENZYMATIC SYNTHESIS OF 5'-PHOSPHORIBOSYLIMIDAZOLEACETIC ACID.
  Journal
J. Biol. Chem. 239 (1964) 2593-601.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37318-65-3

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