KEGG   ENZYME: 6.4.1.8Help
Entry
EC 6.4.1.8                  Enzyme                                 

Name
acetophenone carboxylase
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
acetophenone:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
2 ATP + acetophenone + HCO3- + H2O + H+ = 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate [RN:R05453]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
acetophenone [CPD:C07113];
HCO3- [CPD:C00288];
H2O [CPD:C00001];
H+ [CPD:C00080]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
3-oxo-3-phenylpropanoate [CPD:C07114]
Comment
The enzyme is involved in anaerobic degradation of ethylbenzene. No activity with acetone, butanone, 4-hydroxy-acetophenone or 4-amino-acetophenone.
History
EC 6.4.1.8 created 2011
Pathway
Ethylbenzene degradation
Microbial metabolism in diverse environments
Orthology
K10701  
acetophenone carboxylase
Genes
EBA: 
c1A100(apc4) c1A102(apc3) c1A105(apc1) c1A200(apc2) c1A97(apc5)
Taxonomy
Reference
1  [PMID:20047908]
  Authors
Jobst B, Schuhle K, Linne U, Heider J
  Title
ATP-dependent carboxylation of acetophenone by a novel type of carboxylase.
  Journal
J. Bacteriol. 192 (2010) 1387-94.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

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