KEGG ENZYME: 6.4.1.9

ENZYME: 6.4.1.9

Entry

EC 6.4.1.9                  Enzyme

Name

coenzyme F430 synthetase;
cfbE (gene name)

Class

Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

Sysname

15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)

Reaction(IUBMB)

ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]

Reaction(KEGG)

R11629

Substrate

ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]

Comment

The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.

History

EC 6.4.1.9 created 2017

Pathway

ec00860

Porphyrin metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K21612

coenzyme F430 synthetase

Genes

MJA:

MJ_0258

MFE:	Mefer_0369

MVU:	Metvu_0835

MFS:	MFS40622_0485

MIF:	Metin_0369

MJH:	JH146_0166

MESG:

MLAUSG7_0002(cfbE)

MESA:

MLASG1_1035

MIG:	Metig_0368

MMP:

MMP0173

MMQ:	MmarC5_1502

MMX:	MmarC6_0778

MMZ:	MmarC7_1173

MMD:

GYY_00885

MMAK:

MMKA1_01780

MMAO:

MMOS7_02040

MMAD:

MMJJ_09110

MAE:

Maeo_1414

MVN:	Mevan_1177

MVO:

Mvol_1454

MOK:	Metok_0796

METF:

CFE53_01605

MTH:

MTH_873

MMG:	MTBMA_c12680(murF)

MWO:	MWSIV6_1247

MTEE:

MTTB_05080

METC:

MTCT_0791

METE:

tca_00838(murF)

METZ:

METMT2_0941

METK:

FVF72_07190(cfbE)

MTHM:

FZP57_05930(cfbE)

METJ:

FZP68_00275(cfbE)

MST:

Msp_1331

METB:

AW729_08865

MEIS:

PXD04_00525(cfbE)

MRU:

mru_1745

MSI:

Msm_0880

MEB:

Abm4_0460

MMIL:

sm9_1831

MEYE:

TL18_08530

MOL:

YLM1_1199

MARO:

MarbSA_18380

METV:

K4897_07095(cfbE)

MEL:	Metbo_2343

MEW:	MSWAN_0316

METH:

MBMB1_0355

MFC:

BRM9_1909

MFI:	DSM1535_0095

MCUB:

MCBB_0331

MSUB:

BK009_11970

METN:

BK008_07610

METT:

CIT01_02205

METO:

CIT02_05050

MEME:

HYG87_03660(cfbE)

MFEG:

GCM10025860_12510

MFV:

Mfer_1205

MKA:	MK1590(murF)

MBA:	Mbar_A0345

MBY:	MSBRM_0574

MBW:	MSBRW_0652

MBAR:

MSBR2_1805

MBAK:

MSBR3_2860

MAC:	MA_3630(murD)

MMA:

MM_0516

MMJ:	MSMAS_0790

MMAC:

MSMAC_0769

MVC:	MSVAZ_3048

MEK:	MSKOL_2990

MLS:	MSLAZ_2303

METM:

MSMTP_0888

MEF:	MSWH1_2456

MEQ:	MSWHS_2587

MSJ:	MSSAC_1226

MSZ:	MSSIH_2812

MSW:	MSSIT_2846

MTHR:

MSTHT_2449

MTHE:

MSTHC_0833

MHOR:

MSHOH_0893

MFZ:	AOB57_003180(cfbE)

MBU:

Mbur_1036

MMET:

MCMEM_1518

MELO:

J7W08_06400(cfbE)

MMH:

Mmah_1411

MHAZ:

BHR79_06620

MPOT:

BKM01_02865

MEV:	Metev_0557

MZH:	Mzhil_0470

MPY:

Mpsy_0961

MZI:	HWN40_03730(cfbE)

MMAV:

RE476_06485(cfbE)

MSEB:

RE474_02025(cfbE)

MHZ:	Metho_0544

MEHF:

MmiHf6_07030(murD)

MEES:

MmiEs2_02380(murD)

MTP:

Mthe_0105

MCJ:

MCON_1929

MHI:

Mhar_2390

MHU:

Mhun_0669

MRTJ:

KHC33_10025(cfbE)

MLA:

Mlab_0519

MEM:	Memar_1732

MBG:	BN140_0719

MCHK:

MchiMG62_19340

MSUM:

OH143_02890(cfbE)

MRC:	R6Y96_04910(cfbE)

MPI:

Mpet_1001

MEFW:

F1737_06055(cfbE)

MAQE:

RJ40_03900(cfbE)

MFK:	E2N92_04055(cfbE)

MESB:

L1S32_04110(cfbE)

MANQ:

L1994_05915

MBN:

Mboo_1418

MFO:	Metfor_1749

MPL:

Mpal_0680

MPD:

MCP_0362

MEZ:	Mtc_0062(murD)

RCI:	RCIX2005(murD)

MELU:

MTLP_03860

MEAM:

MU439_05085

MEAE:

QEN48_05070

TAR:	TALC_01252

MAX:	MMALV_13220

MER:	MMINT_17240

MEAR:

Mpt1_c08030

MEUZ:

KRP56_02455(cfbE)

MARC:

AR505_0361

» show all

Reference

1 [PMID:27846569]

Authors

Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO

Title

The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.

Journal

Science 354:339-342 (2016)
DOI:10.1126/science.aag2947

Sequence

[mac:MA_3630]

Other DBs

ExplorEnz - The Enzyme Database:

6.4.1.9

IUBMB Enzyme Nomenclature:

6.4.1.9

ExPASy - ENZYME nomenclature database:

6.4.1.9

BRENDA, the Enzyme Database:

6.4.1.9

DBGET integrated database retrieval system