KEGG   ENZYME: 6.4.1.9Help
Entry
EC 6.4.1.9                  Enzyme                                 

Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
Porphyrin and chlorophyll metabolism
Orthology
K21612  
coenzyme F430 synthetase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_3630(murD)
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMJ: 
MMAC: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MHAZ: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
Mtc_0062(murD)
RCI: 
RCIX2005(murD)
MTH: 
MMG: 
METC: 
MWO: 
MST: 
MSI: 
MRU: 
MEB: 
MMIL: 
MEYE: 
MOL: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MCUB: 
MFV: 
MKA: 
MK1590(murF)
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
 » show all
Taxonomy
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO.
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science. 354 (2016) 339-342.
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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