KEGG   ENZYME: 6.5.1.5Help
Entry
EC 6.5.1.5                  Enzyme                                 

Name
RNA 3'-terminal-phosphate cyclase (GTP);
Pf-Rtc;
RNA-3'-phosphate cyclase (GTP)
Class
Ligases;
Forming phosphoric-ester bonds;
Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
RNA-3'-phosphate:RNA ligase (cyclizing, GMP-forming)
Reaction(IUBMB)
GTP + RNA 3'-terminal-phosphate = GMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate [RN:R10537]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
RNA 3'-terminal-phosphate [CPD:C03638]
Product
GMP [CPD:C00144];
diphosphate [CPD:C00013];
RNA terminal-2',3'-cyclic-phosphate [CPD:C04312]
Comment
The enzyme from the archaeon Pyrococcus furiosus is activated by Mg2+. cf. EC 6.5.1.4, RNA-3'-phosphate cyclase (ATP).
History
EC 6.5.1.5 created 2013
Orthology
K18105  
RNA 3'-terminal phosphate cyclase (GTP)
Genes
MKA: 
MK0001(RCL1)
PHO: 
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TGAM_2020(rtcA)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
 » show all
Taxonomy
Reference
1  [PMID:22074260]
  Authors
Sato A, Soga T, Igarashi K, Takesue K, Tomita M, Kanai A
  Title
GTP-dependent RNA 3'-terminal phosphate cyclase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
Genes. Cells. 16 (2011) 1190-9.
  Organism
Pyrococcus furiosus
  Sequence
[pfu:PF1549]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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