KEGG   Equus caballus (horse): 100051341Help
Entry
100051341         CDS       T01058                                 

Gene name
MTOR
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
ecb  Equus caballus (horse)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Class
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:ecb04012]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:ecb04066]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:ecb04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:ecb04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:ecb04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:ecb04920]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:ecb04919]
Human Diseases; Cancers; Pathways in cancer [PATH:ecb05200]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:ecb05206]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:ecb05205]
Human Diseases; Cancers; Glioma [PATH:ecb05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:ecb05221]
Human Diseases; Cancers; Prostate cancer [PATH:ecb05215]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:ecb04930]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
2
AA seq 2550 aa AA seqDB search
MLGTGPAAATTATTTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPCPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRPTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHTSGANITNAATAATTAATATATATSTEGSNSESEAESTENS
PTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDV
NEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVA
SKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYF
GERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQ
AWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPS
LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN
LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT
LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDR
HPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRIT
CHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILD
GVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDETL
DVPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7653 nt NT seq  +upstreamnt  +downstreamnt
atgcttgggaccggacctgccgccgccaccacagctaccaccacatccagcaatgtgagc
gttctgcagcagtttgccagtggtctgaagagccggaatgaggagaccagagcaaaagct
gccaaggagctccagcactatgtcaccatggagcttcgagagatgagtcaagaggagtca
actcgcttctatgatcaactgaaccatcacatttttgaactggtttccagctcagatgcc
aatgagaggaaaggtggcatcttggccatagccagcctcataggagtggaaggcggcaat
gccacccggatcggcagatttgctaactatcttcggaacctccttccctctaatgaccca
gttgtcatggaaatggcctccaaggctattggccgccttgccatggcaggggacactttc
actgctgagtacgtggagtttgaggtgaagcgagccctggaatggctgggtgctgaccgc
aacgagggccggagacatgcagctgttctggttctccgtgagctggccatcagcgtcccc
accttcttcttccagcaagtgcaacccttctttgacaacatttttgtggctgtatgggat
cccaaacaggccatccgtgagggagctgtagctgcccttcgtgcctgtctgattctcacc
acccagcgtgagccaaaggagatgcagaagccccagtggtacaggcacacattcgaagaa
gcggagaaagggtttgacgagaccttggccaaggagaagggcatgaatcgggatgatcgg
atccatggagccttgctgatcctcaatgagctggtccgaatcagcagcatggagggagag
cgcctgagagaagaaatggaagaaatcacacagcagcaattggtccatgacaagtactgc
aaagatctcatgggcttcggaacaaaacctcgccacattaccccctttaccagtttccag
gctgtgcagccccagcagtcaaatgccttggtaggactgctgggatacagctctcaccaa
ggcctcatgggatttggggcttccccctgcccagctaagtccaccctggtggagagccgg
tgttgcagagacttgatggaggagaaatttgatcaggtgtgccagtgggtgctgaaatgc
aggaatagcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcttggct
gcatttcggccttctgccttcacagatacccagtacctccaagataccatgaaccatgtc
ctaagctgtgtcaagaaggagaaggaacgtacagcagccttccaagccctggggctactt
tctgtggctgtgaggtctgagtttaaggtctatttacctcgtgtgctggacatcattcga
gcagccttgccccctaaggactttgcccataagagacagaaggcaatgcaggtggacgcc
acagtgttcacttgcatcagcatgttagctcgagcaatgggtccaggcatccagcaggat
atcaaggagctgctagagcccatgctggcagtgggactgagccctgccctcacagctgtg
ctctatgacctgagccgtcagattccacagctgaagaaggacatccaagatgggctactg
aagatgctgtccctggtccttatgcacaaacccctccggcacccaggaatgcccaagggc
ctagcccatcagctggcttcccctggcctcacaaccctccctgaggccagcgatgtgggc
agcatcactcttgccctccgaactcttggcagctttgaatttgaaggccactctctgacc
cagtttgtccgccactgtgcggatcatttcctgaacagcgagcacaaggagatccgcatg
gaagccgcccgcacctgctcccgcctgctcacgccctctgtccacctcatcagcggccac
gctcatgtggttagccagactgcagtgcaagtggtagcagatgtactcagcaaactgctc
gtggttgggataacagatcctgaccctgacatccgctactgtgtcttggcatccctggat
gagcgctttgatgcacacctggcccaggcagagaatttgcaggccctctttgtggccctg
aatgaccaagtgtttgagatccgggagctggccatctgcactgtgggccggctcagtagc
atgaacccagctttcgtcatgcctttcctacgcaagatgctcatccagattttgacagag
ctggagcacagtggcattggaagaatcaaagagcagagtgcccgcatgctggggcacctt
gtctccaacgctccccggctcatccgcccctacatggagcctattctgaaggctttaatt
ttgaaactgaaagatccagaccctgatccaaacccaggtgtgatcaataatgtcttggct
acaataggagaattggctcaggttagtggcttagaaatgagaaaatgggttgatgaactg
tttatcatcatcatggacatgctccaggactcttctcttttggccaaaaggcaggtggct
ctctggaccctgggacagttggtggccagcactggttatgtggtggagccctacaggaag
taccccactttgcttgaggtgctgctgaattttctgaagactgagcagaaccagggtacc
cggagagaggctatccgtgtgttagggcttctgggggccttggatccctacaagcacaaa
gtgaacatcggcatgatcgaccagtcccgtgatgcttctgctgtcagcctgtcagaatcc
aagtcaagtcaggattcctctgactacagcaccagtgaaatgctggtcaacatggggaac
ctgcctctggacgagttctacccagctgtgtccatggtggccctgatgcggatcttccga
gaccagtccctctctcaccatcacaccatggttgtccaggccatcaccttcatcttcaag
tccctggggctcaagtgtgtgcagttcctgccccaggtcatgcccacgttcctgaatgtc
attcgggtctgtgacggggccatccgggaatttctgttccagcagttgggaatgttggtg
tcctttgtgaagagccacatcagaccttatatggatgaaatagtcaccctcatgagagaa
ttctgggtcatgaacacctcaatccagagcacaatcattcttctcattgagcaaattgtg
gtagctcttgggggtgaatttaagctgtacctgccccagctgatcccgcacatgctacgt
gtcttcatgcatgacaacagcccaggccgcattgtctccatcaagttgctggctgcaatc
cagctgtttggtgccaacctggatgactatctgcacttgttgttgcctccgattgtgaag
ttgtttgatgcccctgaagttccactgccatctcgaaaggcagcattagagacggtggac
cgcctaacagagtccctggatttcactgactatgcctcccggatcattcacccaattgtt
cgaacactggaccagagcccagaactgcgtcccacagccatggacaccttgtcttcactt
gtctttcagctggggaagaagtatcaaattttcattccaatggtgaataaagtcctggtg
cgacaccgaatcaaccatcagcgctatgatgtgcttatctgcagaattgtcaagggatac
acccttgctgatgaagaagaggaccctttgatttaccagcatcgaatgctgaggagtggc
caaggggatgcattggctagtggaccagtagaaacggggcccatgaagaaactgcatgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtctccaaagatgactgg
ctggaatggctgcggcggctgagtctggagctgctgaaggactcctcatcaccctccctg
cgctcctgctgggccctggctcaggcctacaacccaatggccagggatctcttcaatgct
gcatttgtgtcctgctggtctgaactgaatgaagaccagcaggatgaactcattagaagc
atcgagttggccctcacttcacaggacattgctgaagtcacacaaacgctcttaaacttg
gctgaattcatggaacacagtgacaagggccccctgccattgagagacgacaatggcatc
gtcctgctgggtgagagggctgccaagtgccgagcatatgccaaagcactacactacaaa
gaactggagttccagaaaggtccaacccccgccatcctagaatctctcatcagcattaat
aataagctacagcaaccagaggcagctgccggggtgttagaatacgccatgaaacacttt
ggagagctggagattcaggctacctggtatgagaaactgcatgagtgggaggatgctctt
gtagcatatgataagaaaatggacaccaacaaggatgacccagagctgatgctgggccgc
atgcgctgcctcgaggccttgggggaatgggggcagctccaccagcagtgctgtgaaaag
tggaccctggttaatgatgagacccaagccaagatggcccggatggctgctgcagccgcg
tggggcttaggtcagtgggacagcatggaagagtacacctgtatgatccctcgggacacc
cacgatggggcattttatagggctgtgctggcactacatcaggacctcttctccttggca
caacagtgcatcgacaaagccagagacctgctggatgctgagttaaccgctatggcagga
gagagctacagtcgggcatatggggccatggtttcttgccacatgctctctgagctggag
gaggttatccagtacaaacttgtccccgagcgacgagagatcatccgccagatctggtgg
gagagactgcagggctgccagcgtattgtggaggactggcagaaaatccttatggtgcgc
tcccttgtggtcagccctcatgaggacatgaggacctggctcaagtatgcaagcctatgt
ggcaagagtggcaggctggctcttgctcataaaaccttagtgttgctcctgggagttgat
ccatctcggcaacttgaccatcctctgccaacagttcatcctcaggtgacctacgcctac
atgaaaaacatgtggaagagtgctcgcaagatcgatgccttccagcacatgcagcacttt
gttcagaccatgcagcagcaggcccagcacgccattgctactgaggaccagcagcacaag
caagagctgcacaagctcatggcccggtgtttcctgaaactcggggagtggcagctgaac
ctacagggcatcaacgagagcaccatccccaaagtcctgcagtactacagcgccgccacg
gagcacgaccgcagctggtacaaggcctggcatgcatgggcagtgatgaacttcgaagct
gtgctacactacaaacatcagaaccaagcccgtgatgagaagaagaagctgcgtcacacc
agtggggccaacatcaccaatgcggccactgctgccaccacagcagccactgccaccgcc
actgccaccagcactgagggcagcaacagtgagagcgaggccgagagcaccgagaacagc
cctaccccatctcctctgcagaagaaggtcactgaggatttgtccaaaaccctcttgatg
tacactgtccctgctgtccagggcttcttccgttctatctcgctgtcacgaggcaacaac
ctccaggatacgctcagagtcctcaccttatggtttgattatggccactggccagatgta
aatgaagccttagtggaaggggtgaaagcgatccagattgacacttggttacaggttata
cctcagctcattgcaagaattgatacacccaggcccttggtgggacgtctcattcaccag
cttctcacagacattggtcggtaccacccccaggccctcatctaccccttgactgtggct
tctaagtccaccaccacagcccgtcacaacgcagccaacaagattctgaagaacatgtgt
gagcacagtaacaccctggtccagcaggccatgatggtgagtgaggagctgatccgagtg
gccatcctctggcatgagatgtggcatgaaggcctggaggaagcgtcgcgtttgtacttt
ggggagaggaatgtgaaaggcatgtttgaggtgctggagcccctgcatgctatgatggaa
cggggaccccagactctgaaggaaacatcctttaaccaggcgtatggtcgagatttaatg
gaggcccaagagtggtgcaggaagtatatgaaatcagggaatgtcaaggatctcactcaa
gcctgggacctctattatcatgtgttcagacgaatctcaaagcagctgcctcagctcaca
tccttagagctgcaatatgtttccccaaaacttctgatgtgccgggacctcgaattggct
gtgccaggaacctatgaccccaaccagccgatcattcgcattcagtccatagcaccgtct
ttgcaagtcatcacatccaagcagaggccccggaagttgacacttatgggcagcaacggg
catgagtttgttttcctcctgaagggccatgaagatctacgacaggacgaacgagtgatg
cagctctttggcctggttaacactcttttggccaatgacccaacatctcttcggaaaaac
ctcagcatccagagatatgctgtcatcccgttatcaactaactcgggcctcatcggctgg
gtcccccactgtgacactctgcatgctctcatccgggactacagggagaaaaagaagatc
cttctcaacattgagcatcgcatcatgttgcggatggctccggactacgatcacctgacc
ctgatgcagaaggtcgaggtgtttgagcatgctgtcaataacacagccggggacgacctg
gccaagctgctgtggctgaaaagccccagctccgaggtgtggtttgaccgaagaaccaat
tatacccgctccttagcagtcatgtccatggttgggtatattttgggcctgggagataga
cacccatccaacctaatgctggaccggctgagtgggaagatcctgcacattgactttggg
gactgctttgaggttgctatgaccagagagaaattcccagagaagattccttttagacta
acaagaatgttgaccaatgctatggaggttaccggtctggatggcaactacagaatcacg
tgccacacagtgatggaagtgcttcgggaacacaaggacagtgtcatggccgtgctggaa
gcctttgtctatgaccccttgctgaactggaggctgatggacacaaataccaaaggcaac
aagcggtcccgaacgaggacagattcctactctgctggccagtcagtagaaattttggat
ggtgtggaacttggggaaccagcccataagaaaacggggaccacagtgccagaatctatt
cattctttcattggagacggtttggtgaaaccagaggccctaaataagaaagctattcaa
attattaacagggttcgagataaactcactggtcgggacttctctcatgatgaaactttg
gatgtcccaacacaagttgagctgctcatcaaacaagcaacatcccatgaaaacctctgc
cagtgctacatcggctggtgtcctttctggtaa

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