KEGG   Equus caballus (horse): 100051623Help
Entry
100051623         CDS       T01058                                 

Gene name
PIK3CD
Definition
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
  KO
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ecb  Equus caballus (horse)
Pathway
Inositol phosphate metabolism
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Cellular senescence
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Fluid shear stress and atherosclerosis
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100051623 (PIK3CD)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100051623 (PIK3CD)
   04015 Rap1 signaling pathway
    100051623 (PIK3CD)
   04012 ErbB signaling pathway
    100051623 (PIK3CD)
   04370 VEGF signaling pathway
    100051623 (PIK3CD)
   04630 Jak-STAT signaling pathway
    100051623 (PIK3CD)
   04668 TNF signaling pathway
    100051623 (PIK3CD)
   04066 HIF-1 signaling pathway
    100051623 (PIK3CD)
   04068 FoxO signaling pathway
    100051623 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    100051623 (PIK3CD)
   04072 Phospholipase D signaling pathway
    100051623 (PIK3CD)
   04071 Sphingolipid signaling pathway
    100051623 (PIK3CD)
   04024 cAMP signaling pathway
    100051623 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    100051623 (PIK3CD)
   04152 AMPK signaling pathway
    100051623 (PIK3CD)
   04150 mTOR signaling pathway
    100051623 (PIK3CD)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    100051623 (PIK3CD)
  Cell growth and death
   04210 Apoptosis
    100051623 (PIK3CD)
   04218 Cellular senescence
    100051623 (PIK3CD)
  Cellular community - eukaryotes
   04510 Focal adhesion
    100051623 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    100051623 (PIK3CD)
  Cell motility
   04810 Regulation of actin cytoskeleton
    100051623 (PIK3CD)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100051623 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    100051623 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    100051623 (PIK3CD)
   04660 T cell receptor signaling pathway
    100051623 (PIK3CD)
   04662 B cell receptor signaling pathway
    100051623 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    100051623 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    100051623 (PIK3CD)
   04670 Leukocyte transendothelial migration
    100051623 (PIK3CD)
   04062 Chemokine signaling pathway
    100051623 (PIK3CD)
  Endocrine system
   04910 Insulin signaling pathway
    100051623 (PIK3CD)
   04923 Regulation of lipolysis in adipocyte
    100051623 (PIK3CD)
   04915 Estrogen signaling pathway
    100051623 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    100051623 (PIK3CD)
   04917 Prolactin signaling pathway
    100051623 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    100051623 (PIK3CD)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100051623 (PIK3CD)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100051623 (PIK3CD)
  Nervous system
   04725 Cholinergic synapse
    100051623 (PIK3CD)
   04722 Neurotrophin signaling pathway
    100051623 (PIK3CD)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100051623 (PIK3CD)
  Development
   04360 Axon guidance
    100051623 (PIK3CD)
   04380 Osteoclast differentiation
    100051623 (PIK3CD)
  Aging
   04211 Longevity regulating pathway - mammal
    100051623 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    100051623 (PIK3CD)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100051623 (PIK3CD)
   05230 Central carbon metabolism in cancer
    100051623 (PIK3CD)
   05231 Choline metabolism in cancer
    100051623 (PIK3CD)
   05205 Proteoglycans in cancer
    100051623 (PIK3CD)
   05203 Viral carcinogenesis
    100051623 (PIK3CD)
   05210 Colorectal cancer
    100051623 (PIK3CD)
   05212 Pancreatic cancer
    100051623 (PIK3CD)
   05214 Glioma
    100051623 (PIK3CD)
   05221 Acute myeloid leukemia
    100051623 (PIK3CD)
   05220 Chronic myeloid leukemia
    100051623 (PIK3CD)
   05218 Melanoma
    100051623 (PIK3CD)
   05211 Renal cell carcinoma
    100051623 (PIK3CD)
   05215 Prostate cancer
    100051623 (PIK3CD)
   05213 Endometrial cancer
    100051623 (PIK3CD)
   05224 Breast cancer
    100051623 (PIK3CD)
   05222 Small cell lung cancer
    100051623 (PIK3CD)
   05223 Non-small cell lung cancer
    100051623 (PIK3CD)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    100051623 (PIK3CD)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100051623 (PIK3CD)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100051623 (PIK3CD)
   04931 Insulin resistance
    100051623 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100051623 (PIK3CD)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100051623 (PIK3CD)
   05166 HTLV-I infection
    100051623 (PIK3CD)
   05162 Measles
    100051623 (PIK3CD)
   05164 Influenza A
    100051623 (PIK3CD)
   05161 Hepatitis B
    100051623 (PIK3CD)
   05160 Hepatitis C
    100051623 (PIK3CD)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    100051623 (PIK3CD)
   05169 Epstein-Barr virus infection
    100051623 (PIK3CD)
   05165 Human papillomavirus infection
    100051623 (PIK3CD)
   05146 Amoebiasis
    100051623 (PIK3CD)
   05142 Chagas disease (American trypanosomiasis)
    100051623 (PIK3CD)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100051623 (PIK3CD)
   01524 Platinum drug resistance
    100051623 (PIK3CD)
   01522 Endocrine resistance
    100051623 (PIK3CD)
Enzymes [BR:ecb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100051623 (PIK3CD)
Membrane trafficking [BR:ecb04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100051623 (PIK3CD)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
UniProt: 
Position
2
AA seq 1044 aa AA seqDB search
MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLV
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAARRQQLGWEAWLQYSFPLQLEPLAGNWGA
STLRFPSRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRLEYLYGSYPLCRFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPTPQVQKPR
TKPPPIPVKKPSSVSLWSLEQPFCVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRNNPNTESAAALVISLPEVAP
HPVYYPALDKILELGRPGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKATKPHTKELMHLCMR
QETYLEALSHLQSPLDPSILLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALERAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt NT seq  +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagcgtg
gctgttgacttcctgctgcccacgggggtctatctgaacttccctgtgtcccgaaatgcc
aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccactcttccac
atgctcagtgaccccgaggcctatgtgttcacctgcgtcaaccagactgcggagcagcag
gagctggaggacgagcagcggcggctgtgtgacatccagcccttcctgccggttctgcgc
ctggtggcccgcgagggcgacagggtgaagaagctcatcaactcgcagatcagccttgtc
atcggcaaaggcctccatgagtttgactccttgcgtgacccagaagtgaatgactttcgc
accaagatgcgccagttctgtgaggaggccgctgcccgccggcaacagctgggctgggag
gcctggctacagtacagctttcccctgcagctggagcccttggcgggaaactggggagcc
agcaccctacggttccccagccgggcccttctggtcaacgtcaagttcgagggcagtgag
gagagcttcaccttccaggtgtccaccaaggacgtgcccctggcactgatggcctgtgcc
ctccggaagaaggccacggtgttccggcagcccctggtggagcagcccgaggactacacg
ctgcaggtgaacgggagactcgagtacctgtacggcagctaccccctctgccgcttccag
tacatctgcagctgcctgcacagcgggctgacccctcatctgaccatggtgcactcctcc
tccatcctcgccatgcgggacgaacagagcaaccccaccccccaagtccaaaaaccgcgc
accaaaccgccccccattcccgtgaagaagccctcctctgtgtccctgtggtccctggag
cagccgttctgcgtcgagctcatccagggcagcaaagtgaacgcagatgagcggatgaag
ctggtggtgcaggctgggcttttccatggtaatgagacgctctgcaagacggtgtccagc
tcggaggtgagcgtgtgctcagagcctgtgtggaaacagcggctggagtttgacatcaac
gtctgcgatctgccgcgcatggcccgtctctgctttgcactttacgccgtgattgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg
gccaacctcatgctgtttgactacaaggaccagctcaagactggggaatgctgcctctac
atgtggccctccgtcccagatgagaaaggggagctgctgaaccccacgggaaccgtgcgc
aataaccccaacactgagagcgctgccgccctggtcatctccctccccgaggtggccccc
caccccgtgtactaccctgcccttgacaagatcttggagctggggcggcccggggagcat
gggcgcttcaccgaggaggagcagctgcagctgcgggagatcctggagcggcgggggtcc
ggggagctgtatgagcatgagaaggacctggtgtggaagatgcgacacgaggtccaggag
cacttccccgaggcactggcccggctgctgctggtcaccaagtggaacaagcatgaggac
gtggcccagatgctctacctgctgtgctcctggcctgagctgcctgtgctgagcgccctg
gagctgctggacttcagcttccccgaccgccacgtgggctccttcgccatcaagtccctg
cggaaactgacggacgacgagcttttccagtacctgctgcagctggtgcaggtgcttaag
tacgagtcctacctcgactgtgagctgaccaaattcctgctggaccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccggtccgagatgcacgtgccgtcggtg
gccctgcgcttcggcctcatcatggaggcgtactgcaggggcagcacccaccacatgaag
gtgctgatgaagcagggggaagcactgagcaaactgaaggccctgaacgactttgtcaaa
gtgagctcccagaaggccaccaagccccacaccaaggagctgatgcacctgtgcatgcgc
caggagacctacctggaggccctctcccacctgcagtcgccgctcgaccccagcatcctg
ctggctgaagtctgtgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
gtcatgtacagcaacgaggaggcgggcagcgatggcagcgtgggcatcatatttaagaac
ggggatgacctccgccaggacatgctgactctgcagatgatccagctcatggacgttctg
tggaagcaggaggggttggacctgaggatgaccccctatggctgcctctccaccggggac
cgcacgggcctcatcgaggtggtgcttcactcagacaccattgccaacatccagctgaac
aagagcaacatggcagccacggccgccttcaacaaggatgccctgctcaactggctcaag
tctaagaaccctggggaggccctggaacgagctattgaggagttcaccctctcctgcgct
ggctactgtgtggccacatacgtgctgggcatcggtgatcggcacagcgacaacatcatg
atccgcgagaatgggcagctgttccacattgattttggccactttctggggaatttcaag
accaagtttggaatcaaccgtgagcgagtcccattcatcctcacctatgactttgtccat
gtgatccagcaggggaagactaataatagtgagaaattcgaaaggttccggggctactgt
gagagggcctacaccatcctgcggcgccacgggctgctcttcctgcacctcttcgccctg
atgcgggcggccggcctgcctgagctcagctgctctaaagacatccaatatctcaaggac
tctctggccttgggaaaaacggaggaggaggctctgaagcacttccgagtgaagtttaac
gaagcgctccgggagagctggaagaccaaagtgaattggctggcccacaacgtgtccaaa
gacaacaggcaatag

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