KEGG   Equus caballus (horse): 100051753Help
Entry
100051753         CDS       T01058                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ecb  Equus caballus (horse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100051753 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100051753 (PIK3CB)
   04015 Rap1 signaling pathway
    100051753 (PIK3CB)
   04012 ErbB signaling pathway
    100051753 (PIK3CB)
   04370 VEGF signaling pathway
    100051753 (PIK3CB)
   04630 Jak-STAT signaling pathway
    100051753 (PIK3CB)
   04668 TNF signaling pathway
    100051753 (PIK3CB)
   04066 HIF-1 signaling pathway
    100051753 (PIK3CB)
   04068 FoxO signaling pathway
    100051753 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    100051753 (PIK3CB)
   04024 cAMP signaling pathway
    100051753 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    100051753 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    100051753 (PIK3CB)
   04152 AMPK signaling pathway
    100051753 (PIK3CB)
   04150 mTOR signaling pathway
    100051753 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100051753 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    100051753 (PIK3CB)
  Cellular commiunity
   04510 Focal adhesion
    100051753 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    100051753 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100051753 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    100051753 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    100051753 (PIK3CB)
   04660 T cell receptor signaling pathway
    100051753 (PIK3CB)
   04662 B cell receptor signaling pathway
    100051753 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    100051753 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    100051753 (PIK3CB)
   04670 Leukocyte transendothelial migration
    100051753 (PIK3CB)
   04062 Chemokine signaling pathway
    100051753 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    100051753 (PIK3CB)
   04915 Estrogen signaling pathway
    100051753 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    100051753 (PIK3CB)
   04917 Prolactin signaling pathway
    100051753 (PIK3CB)
   04921 Oxytocin signaling pathway
    100051753 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    100051753 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100051753 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100051753 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100051753 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    100051753 (PIK3CB)
   04722 Neurotrophin signaling pathway
    100051753 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100051753 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    100051753 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100051753 (PIK3CB)
   05205 Proteoglycans in cancer
    100051753 (PIK3CB)
   05203 Viral carcinogenesis
    100051753 (PIK3CB)
   05210 Colorectal cancer
    100051753 (PIK3CB)
   05212 Pancreatic cancer
    100051753 (PIK3CB)
   05214 Glioma
    100051753 (PIK3CB)
   05221 Acute myeloid leukemia
    100051753 (PIK3CB)
   05220 Chronic myeloid leukemia
    100051753 (PIK3CB)
   05218 Melanoma
    100051753 (PIK3CB)
   05211 Renal cell carcinoma
    100051753 (PIK3CB)
   05215 Prostate cancer
    100051753 (PIK3CB)
   05213 Endometrial cancer
    100051753 (PIK3CB)
   05222 Small cell lung cancer
    100051753 (PIK3CB)
   05223 Non-small cell lung cancer
    100051753 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100051753 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100051753 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100051753 (PIK3CB)
   05166 HTLV-I infection
    100051753 (PIK3CB)
   05162 Measles
    100051753 (PIK3CB)
   05164 Influenza A
    100051753 (PIK3CB)
   05161 Hepatitis B
    100051753 (PIK3CB)
   05160 Hepatitis C
    100051753 (PIK3CB)
   05169 Epstein-Barr virus infection
    100051753 (PIK3CB)
   05146 Amoebiasis
    100051753 (PIK3CB)
   05145 Toxoplasmosis
    100051753 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    100051753 (PIK3CB)
Enzymes [BR:ecb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100051753 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
16
AA seq 1070 aa AA seqDB search
MCFNFMMPPAMADSLDIWSVDSQIVSDGSIRVDFLLPTGIYIQLDVPREAPISYIKQMLW
KQVCDYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRVKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSNLENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIRGKEDE
VSPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRVISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVNCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYTNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcaacttcatgatgcctcctgctatggcagacagccttgacatctggtcagtg
gattcacagatagtatctgatggctccatacgtgtggatttccttttacccactgggatt
tatatccagttggacgtacctcgggaagctcccatttcctatattaaacagatgttatgg
aagcaagtttgcgattacccaatgtttaaccttcttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtgtatgaggagcttgaagatgaaacaagaagactgtgt
gatgtccgaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgatgccttg
aaggatcctgaggtgaatgaattccgagtaaaaatgcgaaaattcagtgaggaaaagatt
cagtcgcttgtgggattgtcttggatggattggctaaagcagacatatccaccagagcat
gaaccctctaaccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaagtatctcctaatatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtttgactattcgtgggaaagaagatgaa
gtcagcccttgtgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgac
cacccattaattcagttccagtatatccggaactgtgtaatgaataggaccttgccccat
tttatacttgtggaatgttgcaagatcaaaaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatctaaccttccccttcctttaccaccaaagaaaacg
cgagttatttctcacgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaactgtaaaagttcacgtcagagctggcctttttcatggt
actgaacttctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatattaatacttgtgacctgccacgaatggctcgatta
tgttttgcagtttatgcagttttggataaagtgaaaacaaagaaatcaactaaaactatt
aatccctctaaatatcagaccatcaggaaatctgggaaagtgcattatccagtagcatgg
gtaaatacgatggtttttgactttaaaggacaattgagatctggagatgtaatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattaccctcccttcgataagattatcgaaaaggcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactcaaagaa
atcttggacagggatcccctgtctcaactgtgtgagaatgaaatggatcttatttggact
ttgagacaagactgcagagagaatttcccacagtcactgccaaaattattgctgtcaatc
aagtggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa
ctacccccccgggaggccctggagcttctagatttcaactatccagatcagtacgtgcgg
gaatatgctgtgaactgcctgcgacagatgagcgatgaagaactctctcaatatctttta
caactggtgcaagttttaaaatatgagccttttttggattgtgccctctctagattccta
ttagaaagagcacttgccaatcggaggatagggcagtttctattttggcacctcaggtca
gaagtgcacattcctgctgtctctgtgcaatttggtgtcattcttgaagcatactgccgg
gggagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcagtgaagctaaacagagccaaagggaaagag
gccatgcacacctgtttaaaacagaatgcttaccgggaggccctctctgacctgcagtca
cctctgaacccgtgtgtcatcctctcagaactctatgttgaaaagtgtaaatacatggat
tccaaaatgaagcctttgtggctggtgtacaccaacaaggtgtttggggaagattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccagatgctg
cgcttgatggatttgctctggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaataaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaagag
tttaccctgtcctgtgccggctactgtgtagcttcttatgtccttggaattggtgacaga
catagcgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagtttggc
cggttccgccaatgttgtgaggatgcgtatctgattttacgacgacatgggaatctcttc
atcactctctttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccctagggaagagtgaagaagaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtaaactggatg
gcccacacagtccggaaagactaccgatcttaa

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