KEGG   Equus caballus (horse): 100057315Help
Entry
100057315         CDS       T01058                                 

Gene name
PLCB2
Definition
phospholipase C, beta 2
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ecb  Equus caballus (horse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100057315 (PLCB2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    100057315 (PLCB2)
   04310 Wnt signaling pathway
    100057315 (PLCB2)
   04020 Calcium signaling pathway
    100057315 (PLCB2)
   04070 Phosphatidylinositol signaling system
    100057315 (PLCB2)
   04022 cGMP - PKG signaling pathway
    100057315 (PLCB2)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    100057315 (PLCB2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100057315 (PLCB2)
   04062 Chemokine signaling pathway
    100057315 (PLCB2)
  Endocrine system
   04911 Insulin secretion
    100057315 (PLCB2)
   04912 GnRH signaling pathway
    100057315 (PLCB2)
   04915 Estrogen signaling pathway
    100057315 (PLCB2)
   04921 Oxytocin signaling pathway
    100057315 (PLCB2)
   04918 Thyroid hormone synthesis
    100057315 (PLCB2)
   04919 Thyroid hormone signaling pathway
    100057315 (PLCB2)
   04916 Melanogenesis
    100057315 (PLCB2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100057315 (PLCB2)
   04270 Vascular smooth muscle contraction
    100057315 (PLCB2)
  Digestive system
   04970 Salivary secretion
    100057315 (PLCB2)
   04971 Gastric acid secretion
    100057315 (PLCB2)
   04972 Pancreatic secretion
    100057315 (PLCB2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    100057315 (PLCB2)
  Nervous system
   04724 Glutamatergic synapse
    100057315 (PLCB2)
   04725 Cholinergic synapse
    100057315 (PLCB2)
   04728 Dopaminergic synapse
    100057315 (PLCB2)
   04726 Serotonergic synapse
    100057315 (PLCB2)
   04720 Long-term potentiation
    100057315 (PLCB2)
   04730 Long-term depression
    100057315 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    100057315 (PLCB2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100057315 (PLCB2)
  Environmental adaptation
   04713 Circadian entrainment
    100057315 (PLCB2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100057315 (PLCB2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    100057315 (PLCB2)
   05016 Huntington's disease
    100057315 (PLCB2)
  Infectious diseases
   05146 Amoebiasis
    100057315 (PLCB2)
   05142 Chagas disease (American trypanosomiasis)
    100057315 (PLCB2)
   05143 African trypanosomiasis
    100057315 (PLCB2)
Enzymes [BR:ecb01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100057315 (PLCB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
1
AA seq 1183 aa AA seqDB search
MSLLNSVLLPRKVKSYLSQGERFIKWDDETTTASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALVKHPLTANAPRSTFLDKILVKLQMQLNLEGKIPVKNLFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LAKFINQKQRDPRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SLLVQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKTPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSAYPVILSFENHVDSPRQQAKM
AEYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNLFSGPADPSKELDGE
AEGSPPPSDPVGEDTVWAGEEGTELEEEVEEEEESGSLDEEEMKKMQSDEGTAGLEVTAY
EEMSSLVNYIQPTKFISFEFSAQKNQSYVISSFTELKAYDLLSKAPVQFVDYNKRQMSRI
YPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRR
QDKQFNPFSVDGIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLS
PSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLH
SESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKFFNAQDKKSVKLKEAMGGLPEK
PFLPANPVPSQVNGALALTSNGSAGAGARAREEVTKEAAEPRTVSLDELRELXGFAKLQR
RHEKELRELERRGVRRWEELLQRGAVQVRSSGSPSRGALAGSQARPGKGSPKKRSLPGGE
EPTGAAPGEGPEGEDAHVQELRDRLELELLQLGEEHYDCILKRKEQHVAEQIAKMMELAR
EKHAAELKTLKETSEIDIKEMKKKLEARRLERIQAMIKITTDKMAQERLKREVNNSHIQE
VVQVIKQMSENLERDQEKLEEKQAACLEQIREMEKKFQQEALAEYETRMKGLEAKMKESV
RGCLRACFPSEAEGKPERPCGASGELCEQDPLTAEADTEESRL
NT seq 3552 nt NT seq  +upstreamnt  +downstreamnt
atgtctctgctcaactctgtcctgctgccccgcaaggtgaaaagttatctaagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacaacagcctccccggttatcctccgcgtg
gatcccaagggctattacttatactggacgtatcagagtaaggagatggagtttctggat
atcaccagcatccgggacacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgggatgtcttcaacatggactttcctgacaataacttcctgctgaagacactcact
gtggtgtccggacccgacatggtggacctcaccttccacaacttcgtctcctacaaggag
aacgtgggcaaggactgggctgaagatgtactggctctggtcaagcacccgctgacggcc
aatgccccccgcagcaccttcctggacaagatcctggtcaagctccagatgcagctcaac
ttggaagggaagattcctgtgaagaatcttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgccctcagtgcctgccacctcccaaaaggcaagaatgacgccatcaatcct
gaggacttcccggaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagatgagatcttcacttcctaccatgccaaggccaaaccctacatgaccaaggagcac
ctggccaaattcatcaaccagaaacagcgggatccccgcctcaactccttgctgttcccg
ccagctcggcctgaccaggtgcaaggcctcatcgacaagtatgagcccagtggcatcaac
gtgcagaggggccagttgtcacctgaaggcatggtgtggtttctctgtgggccggagaac
agtttgctggtccaggacaagctgctgctccaccatgacatgacacagccactcaatcat
tacttcatcaattcctcacacaacacctacctgacagccggtcagttctcaggcctttcc
tcggctgagatgtaccgccaggtgctgctggctggctgccgctgtgtggagctggactgc
tggaaggggaagacccccgacgaggagcccattatcacccatggcttcaccatgaccaca
gacatctatttcaaggaggcaattgaagctattgcagaaagtgcctttaagacctccgcc
taccctgtcatcctgtcatttgaaaaccacgtggactcacctcgccaacaggccaagatg
gctgagtactgccggacgatgtttggggacatgctgctcacagagcccctggaaaagttc
ccattaaaaccaggcatccccctgcccagccctgaggatctccgtggcaagatcctcatc
aagaacaagaaaaacctgttttccggcccagcagaccccagcaaggagctggatggggag
gctgagggcagccccccacccagtgatcctgtgggtgaggacacagtgtgggctggtgag
gaagggactgagctggaggaggaggtggaagaggaggaagagtcaggaagcctggacgaa
gaagagatgaagaagatgcagtcagatgagggtacagcgggcctagaggtgacagcttac
gaggagatgtccagccttgtcaattatatccagcctaccaagttcatttcctttgagttt
tctgcccagaagaaccaaagttatgtcatctcctccttcacagagctcaaggcttatgac
ctgctctccaaggcccccgtacagtttgtggactacaacaagcgccagatgagccgcatt
taccccaagggcacccgcatggactcctccaactacatgccccagatgttctggaatgct
ggttgccagatggtcgccctcaacttccagacgatggacctgcccatgcagcagaacatg
gcgctgtttgagttcaatggccagagtggctacctcctcaagcatgagttcatgcgccgg
caggacaagcagttcaaccctttctctgtggatggcatcgacgtggtggtggccaccact
ctttccattacggtgatctctgggcagttcctgtcagaacgcagtgtgcgcacctatgtg
gaagtggagctgtttggccttcctggggaccccaagaggcgctatcgcaccaagctgtca
cccagtaccaactccatcaatcctgtctggaaggaggagccctttgtctttgagaagatc
ttgatgccagagctggcctccctcagggtggctgtgatggaggaaggcaacaagtttctt
ggacaccgcatcatccccatcaatgctctgaattctggataccaccatctatgcctgcac
agcgagagcaacatgcccctcaccatgcctgcactctttgtcttcctggagatgaaggac
tatgtacctgacacctgggcagatctcaccgtggccctcgccaatcccatcaagttcttt
aatgcccaagataagaagtctgtgaagctcaaggaagccatgggaggtctgcctgagaag
cccttcctgcctgcgaatccagttcccagccaggtcaacggggcactggccctaacgagc
aatgggtcagcaggagctggggccagggccagggaggaggtcacgaaagaagctgcagag
ccacggaccgtcagcctggatgagctgcgggagctgnaaggcttcgcgaagctgcagcgg
cggcacgagaaggagcttcgggagctggagcggcgcggcgtgcggcgctgggaggagctg
ttgcagaggggtgctgtgcaggtccggagctccggttcgccgtcgcggggggcgcttgca
gggtcgcaggctcggccggggaaagggtccccgaagaagaggagcctgccaggtggagag
gagcccaccggggccgccccgggcgagggccccgaaggtgaggacgcgcacgtgcaagag
ctgcgggacaggctggagttggagctgctgcagctgggcgaggagcactacgattgcatc
ctgaagcgcaaagagcagcacgtggctgagcaaatcgccaagatgatggagctggccaga
gagaaacatgcggcagagctgaagaccctcaaggagacctcagagattgacatcaaagag
atgaagaaaaagctggaggccaggaggctggaacggatccaggccatgatcaagatcacc
acggacaagatggcccaggagaggttgaagagagaggttaacaactcccacatccaggag
gtggtgcaggtcatcaagcagatgtcagagaacctggagagggaccaggagaagctggag
gagaagcaggcagcctgcctggaacagatccgggagatggaaaagaagtttcagcaagag
gcgctggcagagtacgagaccaggatgaagggcctggaggccaagatgaaggagtcggtg
agaggctgcctcagggcctgtttcccctcagaggcagagggcaagcctgagaggccctgt
ggggcctccggggagctgtgtgagcaggacccacttacagcagaggcagataccgaggag
agccgcctctga

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