KEGG   Equus caballus (horse): 100058141Help
Entry
100058141         CDS       T01058                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ecb  Equus caballus (horse)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100058141 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100058141 (PIK3CA)
   04015 Rap1 signaling pathway
    100058141 (PIK3CA)
   04012 ErbB signaling pathway
    100058141 (PIK3CA)
   04370 VEGF signaling pathway
    100058141 (PIK3CA)
   04630 Jak-STAT signaling pathway
    100058141 (PIK3CA)
   04668 TNF signaling pathway
    100058141 (PIK3CA)
   04066 HIF-1 signaling pathway
    100058141 (PIK3CA)
   04068 FoxO signaling pathway
    100058141 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    100058141 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    100058141 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    100058141 (PIK3CA)
   04152 AMPK signaling pathway
    100058141 (PIK3CA)
   04150 mTOR signaling pathway
    100058141 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100058141 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    100058141 (PIK3CA)
  Cell communication
   04510 Focal adhesion
    100058141 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    100058141 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    100058141 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    100058141 (PIK3CA)
   04660 T cell receptor signaling pathway
    100058141 (PIK3CA)
   04662 B cell receptor signaling pathway
    100058141 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    100058141 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    100058141 (PIK3CA)
   04670 Leukocyte transendothelial migration
    100058141 (PIK3CA)
   04062 Chemokine signaling pathway
    100058141 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    100058141 (PIK3CA)
   04915 Estrogen signaling pathway
    100058141 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    100058141 (PIK3CA)
   04917 Prolactin signaling pathway
    100058141 (PIK3CA)
   04921 Oxytocin signaling pathway
    100058141 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    100058141 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100058141 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    100058141 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100058141 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    100058141 (PIK3CA)
   04722 Neurotrophin signaling pathway
    100058141 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100058141 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    100058141 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100058141 (PIK3CA)
   05205 Proteoglycans in cancer
    100058141 (PIK3CA)
   05203 Viral carcinogenesis
    100058141 (PIK3CA)
   05210 Colorectal cancer
    100058141 (PIK3CA)
   05212 Pancreatic cancer
    100058141 (PIK3CA)
   05214 Glioma
    100058141 (PIK3CA)
   05221 Acute myeloid leukemia
    100058141 (PIK3CA)
   05220 Chronic myeloid leukemia
    100058141 (PIK3CA)
   05218 Melanoma
    100058141 (PIK3CA)
   05211 Renal cell carcinoma
    100058141 (PIK3CA)
   05215 Prostate cancer
    100058141 (PIK3CA)
   05213 Endometrial cancer
    100058141 (PIK3CA)
   05222 Small cell lung cancer
    100058141 (PIK3CA)
   05223 Non-small cell lung cancer
    100058141 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100058141 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100058141 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    100058141 (PIK3CA)
   05166 HTLV-I infection
    100058141 (PIK3CA)
   05162 Measles
    100058141 (PIK3CA)
   05164 Influenza A
    100058141 (PIK3CA)
   05161 Hepatitis B
    100058141 (PIK3CA)
   05160 Hepatitis C
    100058141 (PIK3CA)
   05169 Epstein-Barr virus infection
    100058141 (PIK3CA)
   05146 Amoebiasis
    100058141 (PIK3CA)
   05145 Toxoplasmosis
    100058141 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    100058141 (PIK3CA)
Enzymes [BR:ecb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100058141 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
19
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccgagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggcc
acattaataactataaagcatgaactatttaaagaagcgagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacgagaagactttgtgaccttcggctttttcaaccctttttaaaa
gttattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
attggtatgccagtgtgtgaatttgatatggttaaagatccagaagtgcaggacttccga
agaaatattctcaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctaccctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcaaaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacagctaaaa
ctgtgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcttagaaaaatatcctctcagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttactctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccagatggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggcagaaagggtgctaaagaggaacattgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggactagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacaactacgagcaatttgtacgcgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctgcccaaattgcttctgtccgttaagtggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgcaattacccagaccctatggttcgcggttttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtacttaattcagctagtgcaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaagtctgagatgcacaataaaacagtc
agtcagaggtttggcctgcttttggagtcctattgtcgtgcatgtggaatgtatttaaag
cacctgaatcggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctgcagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgccaagaggccgctgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggtgatgatttacggcaagatatgctaacacttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttacggttgtctgtca
attggtgactgcgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaagggtgcacttcagttcaacagccacacgctacaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgatctgtttacacgttcg
tgtgctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagatgatggacaactgtttcatatagactttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaggaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccttagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacaccatggtggatggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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