KEGG   Equus caballus (horse): 100061987Help
Entry
100061987         CDS       T01058                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
ecb  Equus caballus (horse)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    100061987 (IRS1)
   04022 cGMP - PKG signaling pathway
    100061987 (IRS1)
   04151 PI3K-Akt signaling pathway
    100061987 (IRS1)
   04152 AMPK signaling pathway
    100061987 (IRS1)
   04150 mTOR signaling pathway
    100061987 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100061987 (IRS1)
   04920 Adipocytokine signaling pathway
    100061987 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100061987 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    100061987 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    100061987 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100061987 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100061987 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
6
AA seq 1239 aa AA seqDB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN
GHYILPRGGNGHRYVPGAGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLERGGGHHR
PDTSTLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGSSSSSSAAPSGSSYGKLWTNGVGGHYSHALPHPKLPMESSGS
KLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEET
ARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARSEPGLPHHLHHQVLQPHLP
RKVDTAAQTNSRLARPTRLSLGDPKASTLPRARDQQQQPPLLHPPEPKSPGEYVNIEFGS
DQPGYLSGPMAPHSSPSVRCPSQLQPAPREEETGPEEYMNMDLGPGRRAAWQESAGVQPG
RVGPAPPGSASMCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRTGIVVEE
VSLPGATAAAPSSTSAASASPAAPQGAGELGARSSLLGGRSTLVAXAAFTRXXXXXXXSQ
SAKVIRADPQGCRRRHSSETFXSTPSATRAGNMVPFGAGAVVGSSGGGSSSTEDVKRHSS
ASFENVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPSQQQPPP
PPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ
NT seq 3720 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctctacacccgggacgagcactttgctatcgcggcggacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggccgcggcccctggggcgggaggcggagggggcagctgcagcggcagctct
ggcctcggcgaggcaggggaggacttgagctacggggacgtgcccccaggacctgcgttc
aaagaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcggcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc
ttcttcattgaagtgggccgttccgcagtgacgggacccggggagttctggatgcaggtg
gatgactctgtggtggctcagaacatgcacgagacaatcctggaggccatgcgggccatg
agcgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctccaaccccatc
agcgtacccctgcgcaggcaccacctcaacaaccccccgcccagccaggtggggctgact
cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggtgggcgggaag
cagggctccttccgtgtccgtgcttccagcgacggcgaaggcactatgtcccgtccagct
tcggtggatggcagtcctgtgagtcctagcaccaacaggacccacgcccaccggcatcgg
ggcagctctcggctgcacccccctctcaaccacagccgctccatccctatgccttcttct
cgatgctcaccttcggccactagcccggtcagtctgtcgtccagcagcaccagtggccac
ggctccacctcagactgtctcttcccgcggcggtctagtgcttctgtgtccggctccccc
agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccgaagt
tccttccgcagtgtcaccccagattccctgggccacaccccaccggcccggggtgaggag
gagttgagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat
ggtcactacattttgcctcggggtggcaatggtcaccgctacgtcccaggagctggcttg
ggcacgagtccagccctggctggagatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagcggactcactctgctggcacatctcctaccatttcccaccagaagacccca
tcccagtcctctgtggcttccattgaggaatatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgcccggctaccggcactcggcctttgtgcccacccat
tcctaccctgaggagggtctggaaatgcaccctttggagcgtggtgggggccaccaccgc
ccagacacctcaactctccacactgatgatggctacatgcccatgtccccaggagtggcc
ccagtgcctggcagccgaaagggcagtggggactatatgcctatgagccccaagagcgtg
tctgccccgcagcaaatcatcaaccccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtccccaagcggcagctgctcccctgacattggaggtgggtccagc
agcagcagcagtgctgccccttctgggagcagctatgggaagctatggacaaatggtgta
gggggccactactctcacgccctcccacaccccaaactacccatggagagcagtgggagc
aagctcttgtcttgtacaggtgactacatgaacatgtcgccagtgggggactccaacact
agcagcccctctgactgctactacggccctgaggacccccagcacaagccagtactctcc
tactactcattgccaaggtcctttaagcacacccagcgccctggggagctggaggagact
gcccggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcagca
gcagaagattcctcttcctccaccagcagtgacagcctgggtgggggatactgtggggct
agatccgagcccggcctcccacatcatctccaccatcaggtcctgcagcctcatctgcct
cgaaaggtggacacagctgcgcagaccaacagccgccttgctcggcccacgaggctgtcc
ctgggtgatcccaaggccagcaccttacctcgggcccgagaccagcagcagcagccaccc
ctgctgcaccctccggagcccaagagcccaggggaatatgtgaatattgaatttgggagt
gatcagccaggctacttatctggccccatggctccccacagctcgccttctgtcaggtgt
ccatcccagctccagccagctcccagagaggaagagactggccctgaagaatacatgaac
atggacttggggccgggccggagggcagcctggcaggagagcgctggggtccagcctggc
agagtaggccctgcgcctcctgggtctgctagcatgtgcaggcctactcgggcagtgccc
agcagccggggtgactacatgaccatgcagatgggttgtccccgtcagagctacgtggac
acctcgccagttgcccccatcagctatgctgacatgcggacgggcattgttgtggaggag
gtgagccttcccggggccacagcggctgctccttcctcaacctcagcagcctctgcttct
cctgctgcacctcaaggggcaggggagctgggggcccgctcttccctgctggggggccgc
agcactttggtggcatgagccgccttcacccgnnnnnnnnnnnnnnnnnnnngcagccag
agtgccaaagtgatccgtgcggatccgcaagggtgccggaggcggcatagctccgagacc
ttcntctcgacacctagtgccacccgggcgggcaatatggtgcccttcggagcgggggct
gtggtggggagcagcggtggtggcagcagcagcactgaggatgtgaagcgccacagctct
gcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagcca
gcccaagtgtgcggggctgctgggggtttggagaatggtcttaactacatagatctggat
ttggtcaaggacttcaaacagcgccctcaggagcgcccctctcagcagcagcctccccca
cccccggcccctcatcagcctcttggcagcagtgagagcagctccaccagccgctccagt
gaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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