KEGG   Equus caballus (horse): 100061987Help
Entry
100061987         CDS       T01058                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
ecb  Equus caballus (horse)
Pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Class
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:ecb04068]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:ecb04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:ecb04150]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:ecb04910]
Organismal Systems; Endocrine system; Adipocytokine signaling pathway [PATH:ecb04920]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:ecb04960]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:ecb04722]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:ecb05206]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:ecb04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:ecb04932]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
6
AA seq 1239 aa AA seqDB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN
GHYILPRGGNGHRYVPGAGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLERGGGHHR
PDTSTLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGSCSPDIGGGSSSSSSAAPSGSSYGKLWTNGVGGHYSHALPHPKLPMESSGS
KLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEET
ARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARSEPGLPHHLHHQVLQPHLP
RKVDTAAQTNSRLARPTRLSLGDPKASTLPRARDQQQQPPLLHPPEPKSPGEYVNIEFGS
DQPGYLSGPMAPHSSPSVRCPSQLQPAPREEETGPEEYMNMDLGPGRRAAWQESAGVQPG
RVGPAPPGSASMCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRTGIVVEE
VSLPGATAAAPSSTSAASASPAAPQGAGELGARSSLLGGRSTLVAXAAFTRXXXXXXXSQ
SAKVIRADPQGCRRRHSSETFXSTPSATRAGNMVPFGAGAVVGSSGGGSSSTEDVKRHSS
ASFENVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPSQQQPPP
PPAPHQPLGSSESSSTSRSSEDLSAYASISFQKQPEDLQ
NT seq 3720 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctctacacccgggacgagcactttgctatcgcggcggacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggccgcggcccctggggcgggaggcggagggggcagctgcagcggcagctct
ggcctcggcgaggcaggggaggacttgagctacggggacgtgcccccaggacctgcgttc
aaagaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcggcggccgtggtgctgcagctgatgaacatcaggcgctgtggccactcagagaacttc
ttcttcattgaagtgggccgttccgcagtgacgggacccggggagttctggatgcaggtg
gatgactctgtggtggctcagaacatgcacgagacaatcctggaggccatgcgggccatg
agcgatgagttccgccctcgcagcaagagccagtcctcgtccaactgctccaaccccatc
agcgtacccctgcgcaggcaccacctcaacaaccccccgcccagccaggtggggctgact
cgccgctcgcgcaccgagagcatcaccgccacctccccggccagcatggtgggcgggaag
cagggctccttccgtgtccgtgcttccagcgacggcgaaggcactatgtcccgtccagct
tcggtggatggcagtcctgtgagtcctagcaccaacaggacccacgcccaccggcatcgg
ggcagctctcggctgcacccccctctcaaccacagccgctccatccctatgccttcttct
cgatgctcaccttcggccactagcccggtcagtctgtcgtccagcagcaccagtggccac
ggctccacctcagactgtctcttcccgcggcggtctagtgcttctgtgtccggctccccc
agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccgaagt
tccttccgcagtgtcaccccagattccctgggccacaccccaccggcccggggtgaggag
gagttgagcaactacatctgcatgggaggcaagggggcctccaccctcactgcccccaat
ggtcactacattttgcctcggggtggcaatggtcaccgctacgtcccaggagctggcttg
ggcacgagtccagccctggctggagatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagcggactcactctgctggcacatctcctaccatttcccaccagaagacccca
tcccagtcctctgtggcttccattgaggaatatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgcccggctaccggcactcggcctttgtgcccacccat
tcctaccctgaggagggtctggaaatgcaccctttggagcgtggtgggggccaccaccgc
ccagacacctcaactctccacactgatgatggctacatgcccatgtccccaggagtggcc
ccagtgcctggcagccgaaagggcagtggggactatatgcctatgagccccaagagcgtg
tctgccccgcagcaaatcatcaaccccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtccccaagcggcagctgctcccctgacattggaggtgggtccagc
agcagcagcagtgctgccccttctgggagcagctatgggaagctatggacaaatggtgta
gggggccactactctcacgccctcccacaccccaaactacccatggagagcagtgggagc
aagctcttgtcttgtacaggtgactacatgaacatgtcgccagtgggggactccaacact
agcagcccctctgactgctactacggccctgaggacccccagcacaagccagtactctcc
tactactcattgccaaggtcctttaagcacacccagcgccctggggagctggaggagact
gcccggcaccagcacctccgcctttcctccagctctggtcgccttctctatgctgcagca
gcagaagattcctcttcctccaccagcagtgacagcctgggtgggggatactgtggggct
agatccgagcccggcctcccacatcatctccaccatcaggtcctgcagcctcatctgcct
cgaaaggtggacacagctgcgcagaccaacagccgccttgctcggcccacgaggctgtcc
ctgggtgatcccaaggccagcaccttacctcgggcccgagaccagcagcagcagccaccc
ctgctgcaccctccggagcccaagagcccaggggaatatgtgaatattgaatttgggagt
gatcagccaggctacttatctggccccatggctccccacagctcgccttctgtcaggtgt
ccatcccagctccagccagctcccagagaggaagagactggccctgaagaatacatgaac
atggacttggggccgggccggagggcagcctggcaggagagcgctggggtccagcctggc
agagtaggccctgcgcctcctgggtctgctagcatgtgcaggcctactcgggcagtgccc
agcagccggggtgactacatgaccatgcagatgggttgtccccgtcagagctacgtggac
acctcgccagttgcccccatcagctatgctgacatgcggacgggcattgttgtggaggag
gtgagccttcccggggccacagcggctgctccttcctcaacctcagcagcctctgcttct
cctgctgcacctcaaggggcaggggagctgggggcccgctcttccctgctggggggccgc
agcactttggtggcatgagccgccttcacccgnnnnnnnnnnnnnnnnnnnngcagccag
agtgccaaagtgatccgtgcggatccgcaagggtgccggaggcggcatagctccgagacc
ttcntctcgacacctagtgccacccgggcgggcaatatggtgcccttcggagcgggggct
gtggtggggagcagcggtggtggcagcagcagcactgaggatgtgaagcgccacagctct
gcttcctttgagaacgtgtggctgaggcctggggagctcgggggagcccccaaggagcca
gcccaagtgtgcggggctgctgggggtttggagaatggtcttaactacatagatctggat
ttggtcaaggacttcaaacagcgccctcaggagcgcccctctcagcagcagcctccccca
cccccggcccctcatcagcctcttggcagcagtgagagcagctccaccagccgctccagt
gaggatttaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag

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