KEGG   Equus caballus (horse): 100066248Help
Entry
100066248         CDS       T01058                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
ecb  Equus caballus (horse)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100066248 (INSR)
   04015 Rap1 signaling pathway
    100066248 (INSR)
   04010 MAPK signaling pathway
    100066248 (INSR)
   04066 HIF-1 signaling pathway
    100066248 (INSR)
   04068 FoxO signaling pathway
    100066248 (INSR)
   04072 Phospholipase D signaling pathway
    100066248 (INSR)
   04022 cGMP - PKG signaling pathway
    100066248 (INSR)
   04151 PI3K-Akt signaling pathway
    100066248 (INSR)
   04152 AMPK signaling pathway
    100066248 (INSR)
   04150 mTOR signaling pathway
    100066248 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    100066248 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100066248 (INSR)
   04923 Regulation of lipolysis in adipocyte
    100066248 (INSR)
   04913 Ovarian Steroidogenesis
    100066248 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100066248 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    100066248 (INSR)
   04213 Longevity regulating pathway - multiple species
    100066248 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100066248 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100066248 (INSR)
   04931 Insulin resistance
    100066248 (INSR)
Enzymes [BR:ecb01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100066248 (INSR)
Protein kinases [BR:ecb01001]
 Tyrosine protein kinases
  InsR family [OT]
   100066248 (INSR)
Enzyme-linked receptors [BR:ecb01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   100066248 (INSR)
Cytokine receptors [BR:ecb04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   100066248 (INSR)
CD molecules [BR:ecb04090]
 Proteins
  100066248 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
Position
7
AA seq 1344 aa AA seqDB search
MDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLE
SLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLAT
IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK
VCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCQDLHNKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKI
RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHY
NPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLTFSHIRTSSDKILLKWE
PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG
WLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTNATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQEEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKH
NQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSSSGPGAEDTRP
SRKRRALADVGNVTVAVPTVPGFPNTSSTSTPTSSEERRPFEKVVNKESLVISGLRHFTG
YRIELQACNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEP
NGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWT
EATYFYVTDYYVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE
YLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKT
VNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSL
RPEAENNPGRPPPTLQEMVQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF
GMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ
GLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSF
PEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHSQREEAGGRDAGSSLGLKRNYEEH
IPYTHMNGGKKNGRILTLPRSNPS
NT seq 4035 nt NT seq  +upstreamnt  +downstreamnt
atggatatccggaacaacctcacgaggctgcacgaactggccaactgctccgtcattgaa
ggacacttgcagattctgttgatgtttaaaacgaggcctgaggatttccgagacctcagt
ttccccaaactcatcatgatcactgattacttgctgctcttccgggtgtacgggctggag
agcctgaaggacctgttccccaacctcacggtcatccggggctctcgtctcttcttcaac
tacgcgctggtcatcttcgagatggttcacctgaaggagcttggcctctacaacctgatg
aacatcacccgcggctccgtccgcatagagaagaacaacgagctgtgctacctggccacc
attgactggtcacgcattctggactcggtggaagataattacattgtgctgaacaaggac
gacaatgaggagtgcggggacatttgtccaggcaccgccaagggcaagaccaactgcccc
gccactgtcatcaacggacagtttgttgagcggtgctggacgcacagccattgccagaaa
gtttgcccgaccatctgtaagtcacacggctgcaccgcggacggcctctgctgccacagc
gagtgtttaggcaactgctctgagcccgacgaccccaccaagtgcgtggcctgccgcaac
ttctacctggacggcaggtgtgtggagacctgcccgcccccgtactatcacttccaagac
tggcgctgtgtcaacttcagcttctgccaggacctgcacaacaaatgcaagaactcccga
aggcagggctgccatcagtacgtcattcacaataacaagtgcatccctgagtgtccctct
gggtacacgatgaattccagcaacttgatgtgtaccccgtgcctgggtccctgtcccaag
gtgtgccacctcctggaaggcgagaagaccatcgactcggtgacgtccgcccaggagctc
cgaggctgcacggtcatcaacgggagcctgatcatcaacatccgagggggcaacaacctg
gcagctgagctagaggccaaccttggactcattgaagaaatttcagggtatctgaaaatc
cgccggtcctacgctctcgtgtcgctttccttcttccggaagttacgcctaattcgggga
gagaccttggaaatcgggaactactcattctacgccttggacaaccagaacctgaggcag
ctatgggactggagcaagcacaacctcaccatcactcaggggaaactcttcttccactat
aatcccaaactctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaaaggg
cgccaggagaggaacgacatcgccctgaagaccaacggggaccaggcgtcctgtgaaaat
gagttacttacattttctcacattcggacatcttctgacaagatcttgctgaaatgggag
ccatattggccccccgacttccgagacctcttgggcttcatgctcttctataaagaggcc
ccttatcagaacgtgacggagtttgatgggcaggatgcctgtggctccaacagctggacg
gtagtggacattgacccacctctgaggtccaacgaccccaagtcacagaaccaccccggg
tggctgatgcgaggtctcaaaccctggacccagtatgccatctttgtcaagaccttggtc
accttttctgatgaacgccggacatacggggccaagagcgacatcatctatgtccagaca
aatgccacgaacccgtctgtccccctggatcccatctccgtttctaattcctcatcccag
attattctgaagtggaagcccccctctgaccccaatgggaacatcacacactacctggtt
ttctgggagaggcaggaggaagacagcgagctgtacgagttggattattgcctcaaaggc
ttgaagctgccctccaggacctggtctccaccgtttgagtctgaggggtcccagaagcac
aatcagagtgagtacgaggagtctgccggcgaatgctgctcctgcccgaagaccgactcc
cagatcctgaaggagctggaggagtcctcgttcaggaagacgttcgaggactatctgcac
aatgtggtttttgtccccagaaaatcctcttcaggccctggtgccgaggacactagaccg
tctcggaaacgcagggcgcttgctgatgtcgggaatgtgacggtggccgtgcccacggtt
ccgggtttccctaatacctcctccaccagcacgcccacgagctcagaggagcgcagaccc
ttcgagaaagtggtgaacaaggagtcgctggtcatctccggcctgcgccattttaccggg
tatcgcatcgagcttcaggcttgcaaccaagattcccccgaagagaggtgcagtgtggcc
gcctatgtcagtgccaggaccatgcctgaagccaaggcggacgacatcgttggccccgtg
actcacgaaatcttcgagaacaatgtcgttcacttgatgtggcaggagcccaaagaaccc
aacggtctgatcgtgctgtacgaagtgagttatcggcgatacggcgatgaggagctgcat
ctctgtgtgtctcgcagacattttgccctggagcggggctgccggctgcgtgggctgccg
ccagggaactacagtgtgcgagtgcgggccacctccctggcaggcaatggctcctggacc
gaagccacttatttctacgtgacagactattacgtcccatcaaatattgcaaaaatcatc
atcggccccctcatctttgtctttctcttcagtgtggtcattggaagcatttacctcttc
ttgagaaagaggcagccagatgggcccctgggaccgctgtacgcttcctcaaaccctgag
tacctcagcgccagtgatgtgtttccctgctctgtgtacgtgccggacgagtgggaggtg
cctcgggagaagatcaccctcctgcgggagctggggcagggctccttcggcatggtgtat
gaaggcaacgccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagaca
gtcaacgagtctgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatg
aagggcttcacctgccatcacgtggtccgcctcctgggggtggtatcgaaaggccagcca
acgctggtggtgatggagttgatggctcatggagacctgaagagctacctccgttccctg
cggccggaggctgagaataaccctggccgccctccccctaccctgcaagagatggttcag
atggcggcggagatcgccgacgggatggcgtacctgaacgccaagaagtttgtgcaccgg
gacctggcagctcgaaactgcatggtcgcccacgattttaccgtcaaaatcggagacttt
ggaatgaccagagacatctacgaaacggattactaccggaaaggaggcaaggggctgctc
cccgtgaggtggatggctcctgaatccctgaaggacggggtctttactacttcttctgac
atgtggtcctttggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaa
ggcctgtctaatgagcaggtgttgaaatttgtcatggatggagggtatctggatcaaccc
gacaattgtcccgagagagtcaccgacctgatgcgtatgtgctggcagttcaaccccaag
atgcggccgaccttcctggagattgtcgacctgctcaaggatgacctgcaccccagcttt
ccagaagtttccttcttccacagcgaggagaacaaggcccccgagagcgaggagctggag
atggagtttgaggacatggagaacgtccccctggatcggtcctcacattcccagagggag
gaggccgggggccgggatgcagggtcctcgctgggtctaaagcggaactatgaggaacac
atcccgtacactcacatgaacgggggcaagaaaaatgggcggattctgactctgccgagg
tcaaatccttcctaa

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