KEGG   Equus caballus (horse): 100068506Help
Entry
100068506         CDS       T01058                                 

Gene name
DOT1L
Definition
DOT1-like histone H3K79 methyltransferase
Orthology
K11427  
histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
ecb  Equus caballus (horse)
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    100068506 (DOT1L)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    100068506 (DOT1L)
Enzymes [BR:ecb01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     100068506 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
7
AA seq 1531 aa AA seqDB search
MAGVDLESRRLSSWASSDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFES
MQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHLLQQVYNHSVTDPEKLNNYEP
FSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADI
PAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVD
HQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPV
SYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRDAKSNTTTPTKVPEGKAAAPVDT
PMDSGAEDEKAGATAVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKASTANPERKPKKTQ
TALDLLHAQTVSQAASPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPTPPALQKLLES
FKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAAQQLFGHCQAQKEEIKRLFQQK
LDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKDNQELRSQSLQLLKARCEELKLD
WSTLSLESLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDGLP
LPLRGKGALGRELEAEPGRLPLELDCSKLSLPHFSSMSPELSMNGHAAGYELCSALSRPS
SKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKLSGLALPDYTRLSPAKLVLRRHLSQDHA
VSSKAAAGELHPRAEHAKENGLPYQSPVIANGIKLSPQDPRPSSPVALQMTGEKGSEKGL
KERTYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPVPQPRDS
SSTLEKQPGAGAHGAASSAAGGRGLALAPAGFSYAGSVAISGALAGSPAPLAPGVEPTAF
DESSSSGSLFATMGSRSSTPQQPPLLVQPRNSGSASPAHQLCASPRLSAAQGPPPDAGKV
DLPCESGLSDPESEARRRVVFTISAGAPGSKQSPSSKHSPLPSGARGDSGQSHGQDSRKR
GRRKRASVGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVNNINQPLEITAISSP
ESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIERKIAT
ISLESKSPPKTLENGGGLAGRKPTPAGEPVNSSKWKSTFSPISDLGLAKAADSPLQASST
LSQNSLFAFRPGLDEPGSADAKLAAHPRKSFPGALAGAGGLSPSSTPPNGFAFSGGLAAD
LSAHSFSDGAALSHKAPEVAGLGAAPSFPAPRGKEAGAAEPGSFVNKRQLDGLGGPKGEG
GKGRDVGELGLPVVGPSDRALLVHSKVGKGRDREPDSKNGHNLFISAATVPPGGLLSGPG
LATAASSAGSATPSAQTHRPFLGSFTPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGL
VHVSSAATRLTNSHAMGSFSSGVAGGAVGGN
NT seq 4596 nt NT seq  +upstreamnt  +downstreamnt
atggcgggtgtggacctagagagtagacggctgagctcatgggcgagctcggacaagcac
cacgatgctgctcacgagatcatcgagaccatccgatgggtgtgtgaagaaatcccagat
ctcaagcttgccatggagaactatgttttaatcgactacgacaccaaaagctttgaaagc
atgcagaggctctgtgacaagtacaaccgggccatcgacagcatccaccagctgtggaag
gggaccacgcagcccatgaagctgaacacgcggccgtccaacgggctcctgcgtcacctg
ctgcagcaggtgtacaaccactcggtgactgaccccgagaagctcaacaactacgagccc
ttctccccggaggtgtacggcgagacctccttcgacctggtggcgcagatgatcgatgag
atcaagatgactgaggacgacctattcgtggacctgggcagcggagtgggccaggtcgta
ctgcaggtcgccgctgccaccaactgcaaacatcattatggcgtcgagaaagctgacatc
ccagccaagtacgcagagaccatggaccgagagttcaggaagtggatgaaatggtatgga
aaaaagcatgcagaatacacactggaaagaggcgatttcctctcggaagagtggagagag
cggattgccaacacaagtgttatatttgtgaataactttgcctttggtcctgaggtggat
caccagctgaaggagcgatttgcaaacatgaaggaaggtggcagaattgtgtcctcgaag
ccctttgcacctctgaacttcagaataaacagtagaaacttgagtgacatcggcaccatc
atgcgcgttgtggagctctcgccactgaagggctcggtgtcgtggacggggaagccggtc
tcctactacctgcacaccatcgaccgcaccatacttgaaaactatttttctagtctgaaa
aacccaaaactcagggaggagcaagaggcagcccggcgccggcagcagcgggacgccaag
agcaacacgaccactcccaccaaggtgcccgagggcaaggcggccgcgcctgtggacacc
cccatggattctggtgctgaggacgagaaagctggggcgaccgccgtcaaaaagccgtcc
ccgtccaaagcgcggaagaagaagctgaacaagaagggccggaagatggccggccggaag
cgcgggcgtcccaagaaggcgagcactgcgaaccccgagcgtaagcccaagaagacccaa
actgcactggacctcctgcacgcgcagaccgtgtctcaggcggcgtcgccctcgccgcag
gatgcgtacaagtcacctcacagcccgttctaccagctacctcccagcgtgcagcggcac
ccccccgaccagctgctgctggcccccaccccgcccgcactgcagaagctgctagagtcc
ttcaagattcagtacttgcagttcttggcgtacacgaagacccctcagtacaaggccaac
ctgcagcagctgctggaccaggagaaggagaagaacgctcgcttgctgggcgccgcgcag
cagctgttcggccactgccaggcccagaaggaggagatcaagaggctcttccagcagaag
ctggatgagctgggagtgaaggcgctgacctacaatgacctgatccaagcgcagaaggag
atctcggctcacaaccagcagctgagggagcagacggagcagctggagaaggacaaccag
gagctgcggagccagagcctgcagctgctcaaggctcggtgtgaggagctgaagctggac
tggtccacgctgtccctggagagcctgctgaaggagaagcaggccctgaagagccagatc
tccgagaagcagcggcactgcctggagctgcagatcagcatcgtggagctggagaagagc
cagcggcagcaggagctcctgcagctcaagtcctgcgtgccgcccgacgatggcctgccc
ctgcccctgcgcgggaagggcgcgctgggccgggagctggaggcggagcccggccggctg
cccctggagctggactgctccaagctctccctgccccacttcagcagcatgagcccggag
ctctccatgaacggccacgcggccggctacgagctctgcagcgcgctgagccggccctcg
tccaagcagaacaccccccagtacctggcctccccgctggaccaggaggtcgtgccctgc
acccccagccacggcagccggccgaggctcgagaagctgtccgggctggccttgcctgac
tacacccggctctcgccggccaagctggtgctgaggcgccacctgagccaggaccacgcg
gtcagcagcaaggcagccgctggcgagctgcacccgagagctgagcacgccaaggagaac
ggccttccctaccagagccctgtcatcgccaacgggatcaagctgagccctcaggaccct
cggccctcgtcccccgtggccttacagatgacgggagagaagggcagcgagaagggcctg
aaggagcgcacctacgccagcagcggggaggccatcaccagcctgcccgtgagcatcccg
ctcagcaccgtgcagcccagcaagctgcctgtcagcatccccctggccagcgtggtgctg
cccagccgcgccgagaaggcgagaagcacccccagccctgtgccgcagccccgagactcc
tcatccacactggagaagcagccgggtgccggtgcccatggtgccgcgagcagcgctgct
ggaggcagaggcctcgccctggcacctgcgggattctcctatgctggctccgtggccatc
agtggggccctggcgggcagcccggccccactcgctcctggagtcgagcccaccgccttt
gatgagtcctccagctcggggagcctcttcgccaccatggggtcccgcagctccaccccg
cagcagccccccctgcttgtgcagccgcggaactccggctcggcctcgcccgcccaccag
ctctgcgccagtccacggctcagcgccgcccagggtccgccccccgatgccggcaaggtg
gaccttccgtgcgagtccggcctctccgacccggagagcgaggccaggaggagggtcgtc
ttcaccatctcggcaggtgcccccggctccaagcagtcgccttccagcaagcacagcccc
ctgccctcgggtgcccgtggggacagcggccagagccacgggcaggacagccgcaagcgg
ggcaggaggaagcgggcgtcggtggggacccccagcctcagctcgggtgtgtcccccaag
cgccgggccctgccatccgtcgccggcctcttcacgcagtcttcagggtcccccctgaac
ctcaactccatggtcaacaacatcaaccagcctctggaaatcacggccatctcgtctcca
gagagctccctgaagagctccccggtcccttaccaggacaatgaccagccgcccgtgctc
aagaaggagaagcccctgagccagaccaatggggcccactattccccgctgacctcggac
gaggagcagggctccgaggacgagcccggcagcgccagaattgagagaaaaattgcaact
atctccttagaaagcaaatctcctccaaaaaccttggaaaacggtggcggcctggcgggg
aggaagccgacgcccgccggcgagcccgtcaacagcagcaagtggaagtccaccttctcc
ccgatctccgacctcggcctggccaaggccgccgacagcccgctgcaggccagctccact
ctgagccagaactccctgttcgctttccggcccggcctggacgagcccggctcggctgac
gccaagctggccgcccaccccaggaagagctttcccggcgccctggcaggggctggcggg
ctgagcccgagcagcacccctcccaacggcttcgccttcagcgggggcctggctgctgac
ctcagtgcacacagcttcagtgatggcgctgctctctcccacaaggcccctgaggtggcc
ggcctgggtgccgccccgagctttcccgcgccgaggggcaaggaggccggtgccgcggag
cctggctcatttgtgaacaagaggcagctggatggactgggtggcccgaagggcgagggg
ggcaagggcagggatgtgggcgagctgggcctgcccgtggtcgggccctcggacagggcc
ttgctggtgcacagcaaggtgggcaagggccgcgaccgcgagcccgactccaagaatggc
cacaatctcttcatttctgctgccactgtgcctcccgggggcctcctcagtggaccaggc
ctcgccacagcggcatcctcggcgggcagcgcaacgccctctgcccagacgcaccgcccc
ttcctgggctccttcacccccggcccgcagtttgccctgggccccatgtccctgcaggcc
aacctgggctcgtctgtgctgcagtccttgttcagctccgtgccggccgccgccggcctg
gtgcacgtctcgtccgccgcaaccagactgaccaactcgcacgccatgggcagcttctcc
tccggggtagcaggcggcgcagttggaggtaactag

DBGET integrated database retrieval system