KEGG E.coli: b0074

Escherichia coli K-12 MG1655: b0074

Entry

b0074 CDS E.coli

Gene name leuA, ECK0076, JW0073

Definition 2-isopropylmalate synthase (EC:2.3.3.13)

Orthology K01649 2-isopropylmalate synthase [EC:2.3.3.13]

Pathway eco00290 Valine, leucine and isoleucine biosynthesis
eco00620 Pyruvate metabolism
eco01100 Metabolic pathways

Class Metabolism; Carbohydrate Metabolism; Pyruvate metabolism
[PATH:eco00620]
Metabolism; Amino Acid Metabolism; Valine, leucine and isoleucine
biosynthesis [PATH:eco00290]

SSDB

Motif Pfam: HMGL-like LeuA_dimer
PROSITE: AIPM_HOMOCIT_SYNTH_2 AIPM_HOMOCIT_SYNTH_1 PYR_CT

Other DBs NCBI-GI: 16128068
NCBI-GeneID: 947465
RegulonDB: B0074
EcoGene: EG11226
ECOCYC: EG11226
UniProt: P09151

Position complement(81958..83529)

AA seq 523 aa
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS
LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF
LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA
EAANGNGPVDAVYQAINRITEYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRAAEVEKELQRKAQHNENNKETV

NT seq 1572 nt +upstreamnt +downstreamnt
atgagccagcaagtcattattttcgataccacattgcgcgacggtgaacaggcgttacag
gcaagcttgagtgtgaaagaaaaactgcaaattgcgctggcccttgagcgtatgggtgtt
gacgtgatggaagtcggtttccccgtctcttcgccgggcgattttgaatcggtgcaaacc
atcgcccgccaggttaaaaacagccgcgtatgtgcgttagctcgctgcgtggaaaaagat
atcgacgtggcggccgaatccctgaaagtcgccgaagccttccgtattcatacctttatt
gccacttcgccaatgcacatcgccaccaagctgcgcagcacgctggacgaggtgatcgaa
cgcgctatctatatggtgaaacgcgcccgtaattacaccgatgatgttgaattttcttgc
gaagatgccgggcgtacacccattgccgatctggcgcgagtggtcgaagcggcgattaat
gccggtgccaccaccatcaacattccggacaccgtgggctacaccatgccgtttgagttc
gccggaatcatcagcggcctgtatgaacgcgtgcctaacatcgacaaagccattatctcc
gtacatacccacgacgatttgggcctggcggtcggaaactcactggcggcggtacatgcc
ggtgcacgccaggtggaaggcgcaatgaacgggatcggcgagcgtgccggaaactgttcc
ctggaagaagtcatcatggcgatcaaagttcgtaaggatattctcaacgtccacaccgcc
attaatcaccaggagatatggcgcaccagccagttagttagccagatttgtaatatgccg
atcccggcaaacaaagccattgttggcagcggcgcattcgcacactcctccggtatacac
caggatggcgtgctgaaaaaccgcgaaaactacgaaatcatgacaccagaatctattggt
ctgaaccaaatccagctgaatctgacctctcgttcggggcgtgcggcggtgaaacatcgc
atggatgagatggggtataaagaaagtgaatataatttagacaatttgtacgatgctttc
ctgaagctggcggacaaaaaaggtcaggtgtttgattacgatctggaggcgctggccttc
atcggtaagcagcaagaagagccggagcatttccgtctggattacttcagcgtgcagtct
ggctctaacgatatcgccaccgccgccgtcaaactggcctgtggcgaagaagtcaaagca
gaagccgccaacggtaacggtccggtcgatgccgtctatcaggcaattaaccgcatcact
gaatataacgtcgaactggtgaaatacagcctgaccgccaaaggccacggtaaagatgcg
ctgggtcaggtggatatcgtcgctaactacaacggtcgccgcttccacggcgtcggcctg
gctaccgatattgtcgagtcatctgccaaagccatggtgcacgttctgaacaatatctgg
cgtgccgcagaagtcgaaaaagagttgcaacgcaaagctcaacacaacgaaaacaacaag
gaaaccgtgtga

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (7)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (2)   
   ECOCYC (1)   
   ECOGENE (1)   
   REGULONDB-ECO (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (5)   
   Pfam (2)   
   PROSITE (3)   
All databases (21)

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