KEGG   PATHWAY: ect00520Help
Entry
ect00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Escherichia coli O7:K1 IAI39 (ExPEC)
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Amino sugar and nucleotide sugar metabolism
ect00520

All organismsOrtholog table
Module
PTS system, N-acetylglucosamine-specific II component [PATH:ect00520]
PTS system, D-glucosamine-specific II component [PATH:ect00520]
Nucleotide sugar biosynthesis, prokaryotes [PATH:ect00520]
Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:ect00520]
Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:ect00520]
Organism
Escherichia coli O7:K1 IAI39 (ExPEC) [GN:ect]
Gene
nagZ; beta-hexosaminidase [KO:K01207] [EC:3.2.1.52]
crr; PTS system glucose-specific transporter subunit [KO:K02777] [EC:2.7.1.69]
murP; PTS system N-acetylmuramic acid transporter subunits EIIBC [KO:K11191 K11192] [EC:2.7.1.69]
murQ; N-acetylmuramic acid-6-phosphate etherase [KO:K07106] [EC:4.2.1.126]
nagE; PTS system N-acetyl glucosamine specific transporter subunits IIABC [KO:K02802 K02803 K02804] [EC:2.7.1.69 2.7.1.69]
ycfX; N-acetyl-D-glucosamine kinase [KO:K00884] [EC:2.7.1.59]
glmU; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase [KO:K04042] [EC:2.3.1.157 2.7.7.23]
rffE; UDP-N-acetyl glucosamine-2-epimerase [KO:K01791] [EC:5.1.3.14]
neuC; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
nanK; N-acetylmannosamine kinase [KO:K00885] [EC:2.7.1.60]
nanE; N-acetylmannosamine-6-phosphate 2-epimerase [KO:K01788] [EC:5.1.3.9]
neuB; N-acylneuraminate-9-phosphate synthase [KO:K01654] [EC:2.5.1.56]
nanA; N-acetylneuraminate lyase [KO:K01639] [EC:4.1.3.3]
neuA; N-acylneuraminate cytidylyltransferase [KO:K00983] [EC:2.7.7.43]
wecC; UDP-N-acetyl-D-mannosamine dehydrogenase [KO:K02472] [EC:1.1.1.336]
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
glmM; phosphoglucosamine mutase [KO:K03431] [EC:5.4.2.10]
nagA; N-acetylglucosamine-6-phosphate deacetylase [KO:K01443] [EC:3.5.1.25]
aminoimidazole riboside kinase; K00847 fructokinase [EC:2.7.1.4] [KO:K00847] [EC:2.7.1.4]
mak; fructokinase [KO:K00847] [EC:2.7.1.4]
putative sugar kinase/transcriptional regulator. ATPase domain; K00847 fructokinase [EC:2.7.1.4] [KO:K00847] [EC:2.7.1.4]
nagB; glucosamine-6-phosphate deaminase [KO:K02564] [EC:3.5.99.6]
glmS; glucosamine--fructose-6-phosphate aminotransferase [KO:K00820] [EC:2.6.1.16]
cobB; NAD-dependent deacetylase [KO:K12410] [EC:3.5.1.-]
yfbG; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase [KO:K10011] [EC:1.1.1.305 2.1.2.13]
yfbE; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase [KO:K07806] [EC:2.6.1.87]
yfbF; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase [KO:K10012] [EC:2.7.8.30]
ptsG; PTS system glucose-specific transporter subunits IIBC [KO:K02778 K02779] [EC:2.7.1.69]
glk; glucokinase [KO:K00845] [EC:2.7.1.2]
pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
galU; UTP--glucose-1-phosphate uridylyltransferase subunit GalU [KO:K00963] [EC:2.7.7.9]
galF; UTP--glucose-1-phosphate uridylyltransferase subunit GalF [KO:K00963] [EC:2.7.7.9]
galT; galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]
ugd; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
galK; galactokinase [KO:K00849] [EC:2.7.1.6]
galE; UDP-galactose-4-epimerase [KO:K01784] [EC:5.1.3.2]
manX; PTS system manniose-specific transporter subunit IIAB [KO:K02793 K02794] [EC:2.7.1.69 2.7.1.69]
manY; PTS system mannose-specific protein subunit IIC [KO:K02795]
manZ; PTS system mannose-specific transporter subunit IID [KO:K02796]
cpsG; phosphomannomutase [KO:K01840] [EC:5.4.2.8]
cpsG; phosphomannomutase [KO:K01840] [EC:5.4.2.8]
cpsB; mannose-1-phosphate guanyltransferase [KO:K00971] [EC:2.7.7.13]
gmd; GDP-D-mannose dehydratase, NAD(P)-binding [KO:K01711] [EC:4.2.1.47]
manA; mannose-6-phosphate isomerase [KO:K01809] [EC:5.3.1.8]
fcl; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase [KO:K02377] [EC:1.1.1.271]
glgC; glucose-1-phosphate adenylyltransferase [KO:K00975] [EC:2.7.7.27]
Compound
C00029  
UDP-glucose
C00031  
D-Glucose
C00043  
UDP-N-acetyl-alpha-D-glucosamine
C00052  
UDP-alpha-D-galactose
C00096  
GDP-mannose
C00103  
D-Glucose 1-phosphate
C00124  
D-Galactose
C00128  
CMP-N-acetylneuraminate
C00140  
N-Acetyl-D-glucosamine
C00159  
D-Mannose
C00167  
UDP-glucuronate
C00181  
D-Xylose
C00190  
UDP-D-xylose
C00191  
D-Glucuronate
C00203  
UDP-N-acetyl-D-galactosamine
C00259  
L-Arabinose
C00267  
alpha-D-Glucose
C00270  
N-Acetylneuraminate
C00275  
D-Mannose 6-phosphate
C00325  
GDP-L-fucose
C00329  
D-Glucosamine
C00333  
D-Galacturonate
C00352  
D-Glucosamine 6-phosphate
C00357  
N-Acetyl-D-glucosamine 6-phosphate
C00394  
GDP-glucose
C00446  
alpha-D-Galactose 1-phosphate
C00461  
Chitin
C00498  
ADP-glucose
C00501  
CDP-glucose
C00617  
UDP-D-galacturonate
C00636  
D-Mannose 1-phosphate
C00645  
N-Acetyl-D-mannosamine
C00668  
alpha-D-Glucose 6-phosphate
C00714  
Pectin
C00734  
Chitosan
C00935  
UDP-L-arabinose
C00976  
GDP-D-mannuronate
C00996  
Ferricytochrome b5
C00999  
Ferrocytochrome b5
C01019  
6-Deoxy-L-galactose
C01050  
UDP-N-acetylmuramate
C01170  
UDP-N-acetyl-D-mannosamine
C01219  
CDP-4-dehydro-6-deoxy-D-glucose
C01222  
GDP-4-dehydro-6-deoxy-D-mannose
C01623  
UDP-apiose
C01674  
Chitobiose
C01788  
CDP-abequose
C02199  
UDP-L-rhamnose
C02280  
GDP-L-galactose
C02330  
UDP-L-iduronate
C02336  
beta-D-Fructose
C02352  
1,4-beta-D-Xylan
C02474  
Arabinan
C02713  
N-Acetylmuramate
C02977  
GDP-6-deoxy-D-talose
C02985  
L-Fucose 1-phosphate
C03117  
GDP-6-deoxy-D-mannose
C03410  
N-Glycoloyl-neuraminate
C03598  
CDP-3,6-dideoxy-D-glucose
C03599  
CDP-3,6-dideoxy-D-mannose
C03691  
CMP-N-glycoloylneuraminate
C03737  
alpha-D-Xylose 1-phosphate
C03906  
beta-L-Arabinose 1-phosphate
C04037  
1-Phospho-alpha-D-galacturonate
C04089  
UDP-4-dehydro-6-deoxy-D-glucose
C04257  
N-Acetyl-D-mannosamine 6-phosphate
C04297  
CDP-4-dehydro-3,6-dideoxy-D-glucose
C04501  
N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573  
UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04631  
UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05345  
beta-D-Fructose 6-phosphate
C05385  
D-Glucuronate 1-phosphate
C06023  
D-Glucosaminide
C06156  
alpha-D-Glucosamine 1-phosphate
C06240  
UDP-N-acetyl-D-mannosaminouronate
C06241  
N-Acetylneuraminate 9-phosphate
C11521  
UDP-6-sulfoquinovose
C13952  
UDP-N-acetyl-D-galactosaminuronic acid
C15925  
GDP-L-gulose
C16153  
UDP-L-Ara4N
C16154  
UDP-L-Ara4FN
C16155  
UDP-L-Ara4O
C16156  
Undecaprenyl phosphate alpha-L-Ara4FN
C16698  
N-Acetylmuramic acid 6-phosphate
C17326  
CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C17327  
CDP-ascarylose
C17328  
UDP-4-keto-rhamnose
C19725  
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745  
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19823  
UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19961  
UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971  
UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972  
2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20082  
Pseudaminic acid
C20083  
CMP-pseudaminic acid
C20359  
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395  
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
KO pathway
 
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