KEGG   Escherichia coli clone D i2: i02_0001
Entry
i02_0001          CDS       T02004                                 
Symbol
thrA
Name
(GenBank) bifunctional aspartokinase I/homoserine
  KO
K12524  bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3]
Organism
eld  Escherichia coli clone D i2
Pathway
eld00260  Glycine, serine and threonine metabolism
eld00261  Monobactam biosynthesis
eld00270  Cysteine and methionine metabolism
eld00300  Lysine biosynthesis
eld01100  Metabolic pathways
eld01110  Biosynthesis of secondary metabolites
eld01120  Microbial metabolism in diverse environments
eld01230  Biosynthesis of amino acids
Module
eld_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
eld_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
eld_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:eld00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    i02_0001 (thrA)
   00270 Cysteine and methionine metabolism
    i02_0001 (thrA)
   00300 Lysine biosynthesis
    i02_0001 (thrA)
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    i02_0001 (thrA)
Enzymes [BR:eld01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.3  homoserine dehydrogenase
     i02_0001 (thrA)
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.4  aspartate kinase
     i02_0001 (thrA)
SSDB
Motif
Pfam: Homoserine_dh AA_kinase NAD_binding_3 ACT_7 ACT DUF6247
Other DBs
NCBI-ProteinID: AER82600
Position
336..2798
AA seq 820 aa
MRVLKFGGTSVANAERFLRVADILESNARQGQVATVLSAPAKITNHLVAMIEKTISGQDA
LPNISDAERIFAELLTGLAAAQPGFPLAQLKTFVDQEFAQIKHVLHGISLLGQCPDSINA
ALICRGEKMSIAIMAGVLEARGHNVTVIDPVEKLLAVGHYLESTVDIAESTRRIAASRIP
ADHMVLMAGFTAGNEKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRQV
PDARLLKSMSYQEAMELSYFGAKVLHPRTITPIAQFQIPCLIKNTGNPQAPGTLIGASRD
EDELPVKGISNLNNMAMFSVSGPGMKGMVGMAARVFAAMSRARISVVLITQSSSEYSISF
CVPQSDCVRAERAMQEEFYLELKEGLLEPLAVTERLAIISVVGDGMRTLRGISAKFFAAL
ARANINIVAIAQGSSERSISVVVNNDDATTGVRVTHQMLFNTDQVIEVFVIGVGGVGGAL
LEQLKRQQSWLKNKHIDLRVCGVANSKALLTNVHGLNLENWQEELAQAKEPFNLGRLIRL
VKEYHLLNPVIVDCTSSQAVADQYADFLREGFHVVTPNKKANTSSMDYYHQLRYAAEKSR
RKFLYDTNVGAGLPVIENLQNLLNAGDELMKFSGILSGSLSYIFGKLDEGMSFSEATTLA
REMGYTEPDPRDDLSGMDVARKLLILARETGRELELADIEIEPVLPAEFNAEGDVAAFMA
NLSQLDNLFAARVAKARDEGKVLRYVGNIDEDGVCRVKIAEVDSNDPLFKVKNGENALAF
YSHYYQPLPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV
NT seq 2463 nt   +upstreamnt  +downstreamnt
atgcgagtgttgaagttcggcggtacatcagtggcaaatgcagaacgttttctgcgggtt
gccgatattctggaaagcaatgccaggcaggggcaggtggccaccgtcctctctgccccc
gccaaaatcaccaaccatctggtagcgatgattgaaaaaaccattagcggccaggatgct
ttacccaatatcagcgatgccgaacgtatttttgccgaacttctgacgggactcgccgcc
gcccagccgggatttccgctggcacaattgaaaactttcgtcgaccaggaatttgcccaa
ataaaacatgtcctgcatggcatcagtttgttggggcagtgcccggatagcatcaacgct
gcgctgatttgccgtggcgagaaaatgtcgatcgccattatggccggcgtgttagaagcg
cgtggtcacaacgttaccgttatcgatccggtcgaaaaactgctggcagtgggtcattac
ctcgaatctaccgttgatattgctgaatccacccgccgtattgcggcaagccgcattccg
gctgaccacatggtgctgatggctggtttcactgccggtaatgaaaaaggcgagctggtg
gttctgggacgcaacggttccgactactccgctgcggtgctggcggcctgtttacgcgcc
gattgttgcgagatctggacggatgttgacggtgtttatacctgcgatccgcgtcaggtg
cccgatgcgaggttgttgaagtcgatgtcctatcaggaagcgatggagctttcttacttc
ggcgctaaagttcttcacccccgcaccatcacccccatcgcccagtttcagatcccttgc
ctgattaaaaataccggaaatcctcaagcaccaggtacgctcattggtgccagccgtgat
gaagacgaattaccggtcaagggcatttccaatctgaataacatggcaatgttcagcgtt
tccggcccggggatgaaagggatggttggcatggcggcgcgcgtctttgcagcgatgtca
cgcgcccgtatttccgtggtgctgattacgcaatcatcttccgaatacagtatcagtttc
tgcgttccgcaaagcgactgtgtgcgagctgaacgggcaatgcaggaagagttctacctg
gaactgaaagaaggtttactggagccgttggcggtgacggaacggctggccattatctcg
gtggtaggtgatggtatgcgcaccttacgtgggatctcggcgaaattctttgccgcgctg
gcccgcgccaatatcaacattgtcgccattgctcagggatcttctgaacgctcaatctct
gtcgtggtcaataacgatgatgcgaccactggcgtgcgcgttactcatcagatgctgttc
aataccgatcaggttatcgaagtgtttgtgattggcgtcggtggcgttggcggtgcgctg
ctggagcaactgaagcgtcagcaaagctggttgaagaataaacatatcgacttacgtgtc
tgcggtgttgctaactcgaaggcactcctcaccaatgtacatggccttaatctggaaaac
tggcaggaagaactggcgcaagccaaagagccgtttaatctcgggcgcttaattcgcctc
gtgaaagaatatcatctgctgaacccggtcattgttgactgtacttccagccaggcagtg
gcggatcaatatgccgacttcctgcgcgaaggtttccacgttgttacgccgaacaaaaag
gccaacacctcgtcgatggattactaccatcagttgcgttatgcggcggaaaaatcgcgg
cgtaaattcctctatgacaccaacgttggggctggattaccggttatcgagaacctgcaa
aatctgctcaatgctggtgatgaattgatgaagttctccggcattctttcaggttcgctt
tcttatatcttcggcaagttagacgaaggcatgagtttctccgaggcgaccacactggcg
cgggaaatgggttataccgaaccggacccgcgagatgatctttctggtatggatgtggcg
cgtaagctattgattctcgctcgtgaaacgggacgtgaactggagctggcggatattgaa
attgaacctgtgctgcccgcagagtttaacgccgagggtgatgtcgccgcttttatggcg
aatctgtcacagctcgacaatctctttgccgcgcgtgtggcgaaggcccgtgatgaagga
aaagttttgcgctatgttggcaatattgatgaagatggcgtctgccgcgtgaagattgcc
gaagtggatagtaatgatccgctgttcaaagtgaaaaatggcgaaaacgccctggccttc
tatagccactattatcagccgctgccgttggtactgcgcggatatggtgcgggcaatgac
gttacagctgccggtgtctttgctgatctgctacgtaccctctcatggaagttaggagtc
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (13)   
   KEGG PATHWAY (8)   
   KEGG MODULE (5)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein domain (6)   
   Pfam (6)   
All databases (41)   

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