| Entry |
|
|---|
| Name |
L-xylulose reductase;
xylitol dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming) |
|---|
| Reaction(IUBMB) |
xylitol + NADP+ = L-xylulose + NADPH + H+ [RN:R01904] |
|---|
| Reaction(KEGG) |
R01904
 |
|---|
| Substrate |
xylitol [CPD:C00379];
NADP+ [CPD:C00006] |
|---|
| Product |
L-xylulose [CPD:C00312];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00040 Pentose and glucuronate interconversions
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K03331 L-xylulose reductase |
|---|
| Genes |
HSA: 51181(DCXR)
PTR: 454983(DCXR)
MCC: 715513(DCXR)
MMU: 67880(Dcxr)
MDO: 100029860
BPD: BURPS668_1913
MSM: MSMEG_3262
 |
|---|
| Structures |
PDB: 1PR9 1WNT 3D3W |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2981816]
Doten RC, Mortlock RP.
Characterization of xylitol-utilizing mutants of Erwinia uredovora.
J. Bacteriol. 161 (1985) 529-33.
Erwinia uredovora |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13654257]
HICKMAN J, ASHWELL G.
A sensitive and stereospecific enzymatic assay for xylulose.
J. Biol. Chem. 234 (1959) 758-61.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13416220]
HOLLMANN S, TOUSTER O.
The L-xylulose-xylitol enzyme and other polyol dehydrogenases of
guinea pig liver mitochondria.
J. Biol. Chem. 225 (1957) 87-102.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13357463]
HUTCHESON RM, REYNOLDS VH, TOUSTER O.
The reduction of L-xylulose to xylitol by guinea pig liver
mitochondria.
J. Biol. Chem. 221 (1956) 697-709.
Cavia porcellus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.10
IUBMB Enzyme Nomenclature: 1.1.1.10
ExPASy - ENZYME nomenclature database: 1.1.1.10
BRENDA, the Enzyme Database: 1.1.1.10
CAS: 9028-17-5 |
|---|
