| Entry |
|
|---|
| Name |
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase;
2-keto-3-deoxygluconate 5-dehydrogenase;
2-keto-3-deoxy-D-gluconate dehydrogenase;
2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide
(phosphate)) dehydrogenase;
2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic
acid) dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase |
|---|
| Reaction(IUBMB) |
2-dehydro-3-deoxy-D-gluconate + NAD+ =
(4S)-4,6-dihydroxy-2,5-dioxohexanoate + NADH + H+ [RN:R01542] |
|---|
| Reaction(KEGG) |
R01542
 |
|---|
| Substrate |
2-dehydro-3-deoxy-D-gluconate [CPD:C00204];
NAD+ [CPD:C00003] |
|---|
| Product |
(4S)-4,6-dihydroxy-2,5-dioxohexanoate [CPD:C04349];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
The enzyme from Pseudomonas acts equally well on NAD+ or NADP+,
while that from Erwinia chrysanthemi and Escherichia coli is more
specific for NAD+. |
|---|
| Pathway |
PATH: ec00040 Pentose and glucuronate interconversions |
|---|
Reference
Authors
Title
Journal
|
1
Condemine, G., Hugouvieux-Cotte-Pattat, N. and Robert-Baudouy, J.
An enzyme in the pectolytic pathway of Erwinia chrysanthemi:
3-keto-3-deoxygluconate oxidoreductase.
J. Gen. Microbiol. 130 (1984) 2839-2844. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13986017]
PREISS J, ASHWELL G.
Polygalacturonic acid metabolism in bacteria. II. Formation and
metabolism of 3-deoxy-D-glycero-2, 5-hexodiulosonic acid.
J. Biol. Chem. 238 (1963) 1577-83.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.127
IUBMB Enzyme Nomenclature: 1.1.1.127
ExPASy - ENZYME nomenclature database: 1.1.1.127
BRENDA, the Enzyme Database: 1.1.1.127
CAS: 37250-56-9 |
|---|
