| Entry |
|
|---|
| Name |
3-dehydro-L-gulonate 2-dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase;
3-keto-L-gulonate dehydrogenase;
3-ketogulonate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase |
|---|
| Reaction(IUBMB) |
3-dehydro-L-gulonate + NAD(P)+ =
(4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+
[RN:R02637 R02639] |
|---|
| Reaction(KEGG) |
R02637 R02639
 |
|---|
| Substrate |
3-dehydro-L-gulonate [CPD:C00618];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
(4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate [CPD:C04575];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00040 Pentose and glucuronate interconversions
PATH: ec00053 Ascorbate and aldarate metabolism |
|---|
| Orthology |
KO: K08092 3-dehydro-L-gulonate 2-dehydrogenase |
|---|
| Genes |
ECO: b3575(yiaK)
ECJ: JW3547(yiaK)
ECD: ECDH10B_3756(yiaK)
EBW: BWG_3265(yiaK)
ECG: E2348C_3827(yiaK)
ECC: c4396(yiaK)
ECI: UTI89_C4117(yiaK)
ECP: ECP_3679
ECV: APECO1_2875(yiaK)
ECW: EcE24377A_4072(dlgD)
ECX: EcHS_A3779(dlgD)
ECM: EcSMS35_3898(dlgD)
ECY: ECSE_3851
ECL: EcolC_0139
ECK: EC55989_4032(yiaK)
ECQ: ECED1_4263(yiaK)
ECR: ECIAI1_3742(yiaK)
ECT: ECIAI39_4087(yiaK)
ECZ: ECS88_3994(yiaK)
EUM: ECUMN_4088(yiaK)
ELF: LF82_3339(yiaK)
EBL: B21_03378(yiaK)
EBD: ECBD_0159
EBR: ECB_03427(yiaK)
EOH: ECO103_4659(yiaK)
EOI: ECO111_4395(yiaK)
EOJ: ECO26_5026(yiaK)
EFE: EFER_3573(yiaK)
STY: STY4130
STT: t3851
SPT: SPA3519(yiaK)
SEK: SSPA3286
SPQ: SPAB_04559
SEI: SPC_3748(yiaK)
SEH: SeHA_C3991
SEE: SNSL254_A3946
SEW: SeSA_A3866
SEA: SeAg_B3882
SED: SeD_A4053
SEG: SG3763(yiaK)
SET: SEN3490(yiaK)
STM: STM3668(yiaK)
SFL: SF3619(yiaK)
SFX: S4150(yiaK)
SFV: SFV_3965(yiaK)
SBO: SBO_3583(yiaK)
SBC: SbBS512_E3947(dlgD)
PCT: PC1_3692
PWA: Pecwa_3889
KPE: KPK_0166(dlgD)
CKO: CKO_05033
SPE: Spro_3933
HIN: HI1031
HIQ: CGSHiGG_08775
HSO: HS_0759(mdh)
HSM: HSM_1226
PMU: PM1256
MSU: MS0054
APL: APL_1573
APA: APP7_1635
ASU: Asuc_0268
VSP: VS_II0146
CPY: Cphy_1597
APR: Apre_0576
ACA: ACP_1954
PHE: Phep_3438
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13926592]
VOLK WA, LARSEN JL.
beta-Keto-L-gulonic acid as an intermediate in the bacterial
metabolism of ascorbic acid.
J. Biol. Chem. 237 (1962) 2454-7.
Klebsiella pneumoniae [GN:kpn] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.130
IUBMB Enzyme Nomenclature: 1.1.1.130
ExPASy - ENZYME nomenclature database: 1.1.1.130
BRENDA, the Enzyme Database: 1.1.1.130
CAS: 37250-61-6 |
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