KEGG   ENZYME: 1.1.1.141Help
Entry
EC 1.1.1.141                Enzyme                                 

Name
15-hydroxyprostaglandin dehydrogenase (NAD+);
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I);
PGDH;
11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase;
15-OH-PGDH;
15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostanoic dehydrogenase;
NAD+-specific 15-hydroxyprostaglandin dehydrogenase;
prostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NAD+);
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
Reaction(IUBMB)
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ [RN:R02580]
Reaction(KEGG)
R02580;
(other) R02683
Show
Substrate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate;
NAD+ [CPD:C00003]
Product
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Acts on prostaglandin E2, F2alpha and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).
History
EC 1.1.1.141 created 1972
Orthology
K00069  
15-hydroxyprostaglandin dehydrogenase (NAD)
Genes
HSA: 
3248(HPGD)
PTR: 
461613(HPGD)
PPS: 
100987384(HPGD)
GGO: 
101132897(HPGD)
PON: 
100172788(HPGD)
MCC: 
697864(HPGD)
MCF: 
102140664(HPGD)
MMU: 
15446(Hpgd)
RNO: 
79242(Hpgd)
CGE: 
100755116(Hpgd)
HGL: 
101714528(Hpgd)
TUP: 
102495551(HPGD)
CFA: 
486073(HPGD)
AML: 
FCA: 
101087832(HPGD)
PTG: 
102970212(HPGD)
BTA: 
512259(HPGD)
BOM: 
102269812(HPGD)
PHD: 
102342751(HPGD)
CHX: 
102172997(HPGD)
OAS: 
101112958(HPGD)
SSC: 
100156186(HPGD)
CFR: 
102514446(HPGD)
BACU: 
102998492(HPGD)
LVE: 
103089783(HPGD)
ECB: 
100009687(HPGD)
MYB: 
102255162(HPGD)
MYD: 
102760950(HPGD)
PALE: 
102884381(HPGD)
MDO: 
100018659(HPGD)
SHR: 
100932040(HPGD)
OAA: 
GGA: 
422567(HPGD)
MGP: 
APLA: 
101795486(HPGD)
TGU: 
100229877(HPGD)
FAB: 
101819475(HPGD)
PHI: 
102100222(HPGD)
FPG: 
101913041(HPGD)
FCH: 
102048817(HPGD)
CLV: 
102089275(HPGD)
ASN: 
102375779(HPGD)
AMJ: 
102566187(HPGD)
PSS: 
102457970(HPGD)
CMY: 
102935920(HPGD)
ACS: 
100557290(hpgd)
PBI: 
103049168(HPGD)
XLA: 
446811(hpgd)
XTR: 
493354(hpgd)
DRE: 
393297(zgc:77077) 565975
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
DER: 
DPE: 
DSE: 
DSI: 
DYA: 
AGA: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
NVE: 
HMG: 
TAD: 
AQU: 
CIT: 
CIC: 
ZMA: 
ATR: 
s00126p00099760(AMTR_s00126p00099760)
SMO: 
PPP: 
AFM: 
BSC: 
ACAN: 
PIF: 
 » show all
Taxonomy
Reference
1
  Authors
Anggaard, E. and Samuelsson, B.
  Title
Purification and properties of a 15-hydroxyprostaglandin dehydrogenase from swine lung.
  Journal
Prostaglandins 25 (1996) 293-300.
Reference
2  [PMID:1117007]
  Authors
Braithwaite SS, Jarabak J.
  Title
Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization.
  Journal
J. Biol. Chem. 250 (1975) 2315-8.
Reference
3  [PMID:234431]
  Authors
Lee SC, Levine L.
  Title
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
  Journal
J. Biol. Chem. 250 (1975) 548-52.
Reference
4  [PMID:803247]
  Authors
Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
  Title
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
  Journal
Biochemistry. 14 (1975) 142-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-87-9

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