KEGG   ENZYME: 1.1.1.141Help
Entry
EC 1.1.1.141                Enzyme                                 

Name
15-hydroxyprostaglandin dehydrogenase (NAD+);
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I);
PGDH;
11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase;
15-OH-PGDH;
15-hydroxyprostaglandin dehydrogenase;
15-hydroxyprostanoic dehydrogenase;
NAD+-specific 15-hydroxyprostaglandin dehydrogenase;
prostaglandin dehydrogenase;
15-hydroxyprostaglandin dehydrogenase (NAD+);
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate:NAD+ 15-oxidoreductase
Reaction(IUBMB)
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ [RN:R02580]
Reaction(KEGG)
R02580;
(other) R02683
Show
Substrate
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate;
NAD+ [CPD:C00003]
Product
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Acts on prostaglandin E2, F2alpha and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+).
History
EC 1.1.1.141 created 1972
Orthology
K00069  15-hydroxyprostaglandin dehydrogenase (NAD)
Genes
HSA: 3248(HPGD)
PTR: 461613(HPGD)
PPS: 100987384(HPGD)
GGO: 101132897(HPGD)
PON: 100172788(HPGD)
NLE: 100591825(HPGD)
MCC: 697864(HPGD)
MCF: 102140664(HPGD)
CSAB: 103236551(HPGD)
RRO: 104659921(HPGD)
RBB: 108534045(HPGD)
CJC: 100398196(HPGD)
SBQ: 101040274(HPGD)
MMU: 15446(Hpgd)
RNO: 79242(Hpgd)
CGE: 100755116(Hpgd)
NGI: 103745222(Hpgd)
HGL: 101714528(Hpgd)
OCU: 100348968(HPGD)
TUP: 102495551(HPGD)
CFA: 486073(HPGD)
AML: 100476658(HPGD)
UMR: 103675927(HPGD)
ORO: 101372450(HPGD)
FCA: 101087832(HPGD)
PTG: 102970212(HPGD)
AJU: 106975814(HPGD)
BTA: 512259(HPGD)
BOM: 102269812(HPGD)
BIU: 109562773(HPGD)
PHD: 102342751(HPGD)
CHX: 102172997(HPGD)
OAS: 101112958(HPGD)
SSC: 100156186(HPGD)
CFR: 102514446(HPGD)
CDK: 105101863(HPGD)
BACU: 102998492(HPGD)
LVE: 103089783(HPGD)
OOR: 101282003(HPGD)
ECB: 100009687(HPGD)
EPZ: 103564977(HPGD)
EAI: 106831730(HPGD)
MYB: 102255162(HPGD)
MYD: 102760950(HPGD)
HAI: 109379564(HPGD)
RSS: 109448180(HPGD)
PALE: 102884381(HPGD)
LAV: 100667134(HPGD)
TMU: 101341700
MDO: 100018659(HPGD)
SHR: 100932040(HPGD)
OAA: 100074221(HPGD) 100089678
GGA: 422567(HPGD)
MGP: 100550540(HPGD)
CJO: 107313471(HPGD)
APLA: 101795486(HPGD)
ACYG: 106041765(HPGD)
TGU: 100229877(HPGD)
GFR: 102037923(HPGD)
FAB: 101819475(HPGD)
PHI: 102100222(HPGD)
PMAJ: 107203319(HPGD)
CCW: 104690551(HPGD)
FPG: 101913041(HPGD)
FCH: 102048817(HPGD)
CLV: 102089275(HPGD)
EGZ: 104131081(HPGD)
AAM: 106484005(HPGD)
ASN: 102375779(HPGD)
AMJ: 102566187(HPGD)
PSS: 102457970(HPGD)
CMY: 102935920(HPGD)
CPIC: 101947637(HPGD)
ACS: 100557290(hpgd)
PVT: 110084316(HPGD)
PBI: 103049168(HPGD)
GJA: 107107799(HPGD)
XLA: 108706627(hpgd.S) 446811(hpgd.L)
XTR: 493354(hpgd)
NPR: 108795296(HPGD)
DRE: 393297(zgc:56585) 565975(hpgd)
CCAR: 109078451(hpgd) 109086746
IPU: 108263011(hpgd) 108278852
AMEX: 103022606 103025346(hpgd)
XMA: 102219275 102223588(hpgd)
PRET: 103460018 103472159(hpgd)
NFU: 107386695 107394274(hpgd)
CSEM: 103384297(hpgd) 103394939
HCQ: 109518149 109521693(hpgd)
SASA: 100196521(pgdh) 106602382(PGDH) 106610167(PGDH)
ELS: 105011191 105020908(hpgd)
SFM: 108919973 108924388(hpgd)
LCM: 102348458 102352839(HPGD)
CMK: 103180222(hpgd) 103180223
SPU: 591898
AAG: 23687838
AME: 409847(GB11685)
LHU: 105677232
HMG: 100199952
CIT: 102612508
ZMA: 100381799
PPP: 112281319
 » show all
Taxonomy
Reference
1
  Authors
Anggaard, E. and Samuelsson, B.
  Title
Purification and properties of a 15-hydroxyprostaglandin dehydrogenase from swine lung.
  Journal
Prostaglandins 25 (1996) 293-300.
Reference
2  [PMID:1117007]
  Authors
Braithwaite SS, Jarabak J.
  Title
Studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Purification and partial characterization.
  Journal
J. Biol. Chem. 250 (1975) 2315-8.
Reference
3  [PMID:234431]
  Authors
Lee SC, Levine L.
  Title
Prostaglandin metabolism. II. Identification of two 15-hydroxyprostaglandin dehydrogenase types.
  Journal
J. Biol. Chem. 250 (1975) 548-52.
Reference
4  [PMID:803247]
  Authors
Lee SC, Pong SS, Katzen D, Wu KY, Levine L.
  Title
Distribution of prostaglandin E 9-KETOREDUCTASE AND TYPES I and II 15-hydroxyprostaglandin dehydrogenase in swine kidney medulla and cortex.
  Journal
Biochemistry. 14 (1975) 142-5.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.141
IUBMB Enzyme Nomenclature: 1.1.1.141
ExPASy - ENZYME nomenclature database: 1.1.1.141
BRENDA, the Enzyme Database: 1.1.1.141
CAS: 9030-87-9

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