| Entry |
|
|---|
| Name |
3beta-hydroxy-Delta5-steroid dehydrogenase;
progesterone reductase;
Delta5-3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy-5-ene steroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase/isomerase;
3beta-hydroxy-Delta5-C27-steroid dehydrogenase/isomerase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase;
3beta-hydroxy-5-ene-steroid oxidoreductase;
steroid-Delta5-3beta-ol dehydrogenase;
3beta-HSDH;
5-ene-3-beta-hydroxysteroid dehydrogenase;
3beta-hydroxy-5-ene-steroid dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
3beta-hydroxy-Delta5-steroid:NAD+ 3-oxidoreductase |
|---|
| Reaction(IUBMB) |
a 3beta-hydroxy-Delta5-steroid + NAD+ = a 3-oxo-Delta5-steroid +
NADH + H+ [RN:R03176] |
|---|
| Reaction(KEGG) |
R03176;
(other) R01837 R02216 R02499 R02840 R03327 R04163 R04678 R04849
 |
|---|
| Substrate |
3beta-hydroxy-Delta5-steroid [CPD:C03836];
NAD+ [CPD:C00003] |
|---|
| Product |
3-oxo-Delta5-steroid [CPD:C01034];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Acts on 3beta-hydroxyandrost-5-en-17-one to form
androst-4-ene-3,17-dione and on 3beta-hydroxypregn-5-en-20-one to
form progesterone. |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00070 3beta-hydroxy-delta5-steroid dehydrogenase / steroid
delta-isomerase |
|---|
| Genes |
HSA: 3283(HSD3B1) 3284(HSD3B2)
PTR: 457165(HSD3B2) 469446(HSD3B1)
MCC: 712686(HSD3B2) 713091(HSD3B1)
MMU: 15492(Hsd3b1) 15493(Hsd3b2) 15495(Hsd3b4) 15496(Hsd3b5)
15497(Hsd3b6)
RNO: 24470(Hsd3b5) 29632(Hsd3b6) 360348(Hsd3b1)
CFA: 483146(HSD3B1)
BTA: 281824(HSD3B1)
SSC: 445539(HSD3B1)
ECB: 100034078(HSD3B1)
MDO: 100012668
OAA: 100080135
GGA: 396015(HSD3B1)
TGU: 751770(HSD3B1)
XLA: 734818
DRE: 373131(hsd3b1) 553532
BFO: BRAFLDRAFT_221648
CIN: 100175469 100177791
SPU: 592634
DME: Dmel_CG7724
DPO: Dpse_GA20545
DAN: Dana_GF10105
AGA: AgaP_AGAP006654
AAG: AaeL_AAEL000733
CQU: CpipJ_CPIJ003056
NVI: 100120136
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4226148]
Cheatum SG, Watten JC.
Purification and properties of 3-beta-hydroxysteroid dehydrogenase
and delta-5-3-ketosteroid isomerase from bovine corpora lutea.
Biochim. Biophys. Acta. 122 (1966) 1-13.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14220672]
KORITZ SB.
THE CONVERSION OF PREGNENOLONE TO PROGESTERONE BY SMALL PARTICLES
FROM RAT ADRENAL.
Biochemistry. 3 (1964) 1098-102.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
3
Neville, A.M., Orr, J.C. and Engel, L.L.
Delta5-3beta-Hydroxy steroid dehydrogenase activities of bovine
adrenal cortex.
Biochem. J. 107 (1968) 20. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.145
IUBMB Enzyme Nomenclature: 1.1.1.145
ExPASy - ENZYME nomenclature database: 1.1.1.145
BRENDA, the Enzyme Database: 1.1.1.145
CAS: 9044-85-3 |
|---|
