KEGG   ENZYME: 1.1.1.146Help
Entry
EC 1.1.1.146                Enzyme                                 

Name
11beta-hydroxysteroid dehydrogenase;
corticosteroid 11beta-dehydrogenase;
beta-hydroxysteroid dehydrogenase;
11beta-hydroxy steroid dehydrogenase;
corticosteroid 11-reductase;
dehydrogenase, 11beta-hydroxy steroid
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
11beta-hydroxysteroid:NADP+ 11-oxidoreductase
Reaction(IUBMB)
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ [RN:R03203]
Reaction(KEGG)
Substrate
11beta-hydroxysteroid [CPD:C01058];
NADP+ [CPD:C00006]
Product
11-oxosteroid [CPD:C01985];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.146 created 1972
Pathway
Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Orthology
K15680  
corticosteroid 11-beta-dehydrogenase isozyme 1
Genes
HSA: 
3290(HSD11B1)
PTR: 
457698(HSD11B1)
PPS: 
100981291(HSD11B1)
GGO: 
101147766(HSD11B1)
PON: 
100433824(HSD11B1)
NLE: 
100593811(HSD11B1)
MCC: 
574322(HSD11B1)
MCF: 
CJC: 
100401212(HSD11B1)
MMU: 
15483(Hsd11b1)
RNO: 
25116(Hsd11b1)
CGE: 
100762502(Hsd11b1)
NGI: 
103727028(Hsd11b1)
HGL: 
101716800(Hsd11b1)
OCU: 
100342395(HSD11B1)
TUP: 
102502602(HSD11B1)
CFA: 
449023(HSD11B1)
AML: 
UMR: 
103672488(HSD11B1)
FCA: 
100529248(HSD11B1)
PTG: 
102967279(HSD11B1)
BTA: 
282589(HSD11B1)
BOM: 
102275244(HSD11B1)
PHD: 
102317655(HSD11B1)
CHX: 
102168375(HSD11B1)
OAS: 
443409(HSD11B1)
SSC: 
397480(HSD11B1)
CFR: 
102503994(HSD11B1)
BACU: 
103004239(HSD11B1)
LVE: 
103086619(HSD11B1)
ECB: 
100056429(HSD11B1)
MYB: 
102260050(HSD11B1)
MYD: 
102771648(HSD11B1)
PALE: 
102882377(HSD11B1)
SHR: 
100923255(HSD11B1)
OAA: 
100079059(HSD11B1)
GGA: 
419861(HSD11B1) 771930
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379494(hsd11b1l.2) 379497(hsd11b1) 399012(hsd11b1l-a)
XTR: 
100038278(hsd11b1l.2) 100489345(hsd11b1)
DRE: 
LCM: 
102345616(HSD11B1)
CMK: 
103182506(hsd11b1)
BFO: 
SPU: 
HRO: 
LGI: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:2808402]
  Authors
Agarwal AK, Monder C, Eckstein B, White PC.
  Title
Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.
  Journal
J. Biol. Chem. 264 (1989) 18939-43.
  Sequence
[rno:25116]
Reference
2  [PMID:4384445]
  Authors
Bush IE, Hunter SA, Meigs RA.
  Title
Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver.
  Journal
Biochem. J. 107 (1968) 239-58.
Reference
3  [PMID:3139396]
  Authors
Lakshmi V, Monder C.
  Title
Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex.
  Journal
Endocrinology. 123 (1988) 2390-8.
Reference
4  [PMID:2661206]
  Authors
Phillips DM, Lakshmi V, Monder C.
  Title
Corticosteroid 11 beta-dehydrogenase in rat testis.
  Journal
Endocrinology. 125 (1989) 209-16.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9041-46-7

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