| Entry |
|
|---|
| Name |
11beta-hydroxysteroid dehydrogenase;
corticosteroid 11beta-dehydrogenase;
beta-hydroxysteroid dehydrogenase;
11beta-hydroxy steroid dehydrogenase;
corticosteroid 11-reductase;
dehydrogenase, 11beta-hydroxy steroid |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
11beta-hydroxysteroid:NADP+ 11-oxidoreductase |
|---|
| Reaction(IUBMB) |
an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
[RN:R03203] |
|---|
| Reaction(KEGG) |
R03203 > R02836 R03848 R04758 R04840;
(other) R02834
 |
|---|
| Substrate |
11beta-hydroxysteroid [CPD:C01058];
NADP+ [CPD:C00006] |
|---|
| Product |
11-oxosteroid [CPD:C01985];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00071 11beta-hydroxysteroid dehydrogenase |
|---|
| Genes |
HSA: 3290(HSD11B1) 3291(HSD11B2)
PTR: 457698(HSD11B1) 468001(HSD11B2)
MCC: 574322(HSD11B1) 574396(11-BETA-HSD2)
MMU: 15483(Hsd11b1) 15484(Hsd11b2)
RNO: 25116(Hsd11b1) 25117(Hsd11b2)
CFA: 449023(HSD11B1) 489758(HSD11B2)
BTA: 282434(HSD11B2) 282589(HSD11B1)
SSC: 396948(HSD11B2) 397480(HSD11B1)
ECB: 100034124(HSD11B2) 100056429
OAA: 100079059 100081477
GGA: 419861(HSD11B1)
TGU: 100222854 100225021
XLA: 379494(hsd11b1l-b) 379497 444491
DRE: 334098(hsd11b2) 393293(hsd11b3)
SPU: 764876
ATH: AT3G47350(AtHSD2)
TTH: TTC1745
 |
|---|
| Structures |
PDB: 1XSE 1XU7 1XU9 1Y5M 1Y5R 2BEL 2ILT 2IRW 2RBE 3BYZ
3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3DWF 3EY4 3FCO 3FRJ
3G49 3H6K 3HFG |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2808402]
Agarwal AK, Monder C, Eckstein B, White PC.
Cloning and expression of rat cDNA encoding corticosteroid 11
beta-dehydrogenase.
J. Biol. Chem. 264 (1989) 18939-43.
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4384445]
Bush IE, Hunter SA, Meigs RA.
Metabolism of 11-oxygenated steroids. Metabolism in vitro by
preparations of liver.
Biochem. J. 107 (1968) 239-58.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta], Oryctolagus
cuniculus, Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3139396]
Lakshmi V, Monder C.
Purification and characterization of the corticosteroid 11
beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid
dehydrogenase complex.
Endocrinology. 123 (1988) 2390-8.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:2661206]
Phillips DM, Lakshmi V, Monder C.
Corticosteroid 11 beta-dehydrogenase in rat testis.
Endocrinology. 125 (1989) 209-16.
Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.146
IUBMB Enzyme Nomenclature: 1.1.1.146
ExPASy - ENZYME nomenclature database: 1.1.1.146
BRENDA, the Enzyme Database: 1.1.1.146
CAS: 9041-46-7 |
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