| Entry |
|
|---|
| Name |
estradiol 17alpha-dehydrogenase;
17alpha-estradiol dehydrogenase;
17alpha-hydroxy steroid dehydrogenase;
17alpha-hydroxy steroid oxidoreductase;
17alpha-hydroxysteroid oxidoreductase;
estradiol 17alpha-oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase |
|---|
| Reaction(IUBMB) |
estradiol-17alpha + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02347
R02349] |
|---|
| Reaction(KEGG) |
R02347 R02349
 |
|---|
| Substrate |
estradiol-17alpha [CPD:C02537];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
estrone [CPD:C00468];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Pathway |
PATH: ec00140 Steroid hormone biosynthesis |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4383682]
Renwick AG, Engel LL.
The partial purification of 17 alpha- and 17 beta-estradiol
dehydrogenase activities from chicken liver.
Biochim. Biophys. Acta. 146 (1967) 336-48.
Gallus gallus [GN:gga] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.148
IUBMB Enzyme Nomenclature: 1.1.1.148
ExPASy - ENZYME nomenclature database: 1.1.1.148
BRENDA, the Enzyme Database: 1.1.1.148
CAS: 9044-91-1 |
|---|
