KEGG   ENZYME: 1.1.1.153Help
Entry
EC 1.1.1.153                Enzyme                                 

Name
sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming);
SR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-erythro-7,8-dihydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
(1) L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ [RN:R02975];
(2) L-erythro-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ [RN:R08208]
Reaction(KEGG)
Substrate
L-erythro-7,8-dihydrobiopterin [CPD:C02953];
NADP+ [CPD:C00006];
L-erythro-tetrahydrobiopterin [CPD:C00272]
Product
sepiapterin [CPD:C00835];
NADPH [CPD:C00005];
H+ [CPD:C00080];
6-pyruvoyl-5,6,7,8-tetrahydropterin [CPD:C03684]
Comment
This enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. The enzyme, which is found in higher animals and some fungi and bacteria, produces the erythro form of tetrahydrobiopterin. cf. EC 1.1.1.325, sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming).
History
EC 1.1.1.153 created 1972, modified 2012
Pathway
Folate biosynthesis
Metabolic pathways
Orthology
K00072  
sepiapterin reductase
Genes
HSA: 
6697(SPR)
PTR: 
470403(SPR)
PPS: 
GGO: 
PON: 
MCC: 
705317(SPR)
MCF: 
MMU: 
20751(Spr)
RNO: 
29270(Spr)
CGE: 
HGL: 
TUP: 
CFA: 
483118(SPR)
AML: 
FCA: 
PTG: 
BTA: 
533836(SPR)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
425255(SPR)
MGP: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
380273(spr)
XTR: 
DRE: 
554136(spra)
TRU: 
MZE: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551857(GB18536)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
NVE: 
HMG: 
TAD: 
AQU: 
DDI: 
DPP: 
DFA: 
TGO: 
PTI: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:4401291]
  Authors
Kato S.
  Title
Sepiapterin reductase from horse liver: purification and properties of the enzyme.
  Journal
Arch. Biochem. Biophys. 146 (1971) 202-14.
Reference
2  [PMID:5969298]
  Authors
Matsubara M, Katoh S, Akino M, Kaufman S.
  Title
Sepiapterin reductase.
  Journal
Biochim. Biophys. Acta. 122 (1966) 202-12.
Reference
3  [PMID:7528005]
  Authors
Werner ER, Schmid M, Werner-Felmayer G, Mayer B, Wachter H.
  Title
Synthesis and characterization of 3H-labelled tetrahydrobiopterin.
  Journal
Biochem. J. 304 ( Pt 1) (1994) 189-93.
Reference
4  [PMID:10987137]
  Authors
Kim YA, Chung HJ, Kim YJ, Choi YK, Hwang YK, Lee SW, Park YS.
  Title
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli.
  Journal
Mol. Cells. 10 (2000) 405-10.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-48-7

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