KEGG   ENZYME: 1.1.1.170Help
Entry
EC 1.1.1.170                Enzyme                                 
Name
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenoate dehydrogenase;
sterol 4alpha-carboxylic decarboxylase;
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous);
ERG26 (gene name);
NSDHL (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
Reaction(IUBMB)
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H [RN:R04483 R07149]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid-4alpha-carboxylate;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
The enzyme catalyses the decarboxylation of the C-4 carbon and the dehydrogenation of a 3beta hydroxyl at the C-3 carbon of 3beta-hydroxysteroid-4alpha-carboxylates. It is involved in zymosterol and cholesterol biosynthesis.
Pathway
Steroid biosynthesis
Metabolic pathways
Orthology
K07748  
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
Genes
HSA: 
50814(NSDHL)
PTR: 
465960(NSDHL)
PPS: 
100975917(NSDHL)
GGO: 
101144867(NSDHL)
PON: 
100172372(NSDHL)
MCC: 
693333(NSDHL)
MMU: 
18194(Nsdhl)
RNO: 
309262(Nsdhl)
CFA: 
481079(NSDHL)
AML: 
100466780(NSDHL)
FCA: 
101096551(NSDHL)
BTA: 
616694(NSDHL)
SSC: 
100157894(NSDHL)
ECB: 
100063648(NSDHL)
MDO: 
100026414
SHR: 
100914940(NSDHL)
GGA: 
422302(NSDHL)
MGP: 
100544971
TGU: 
100190543
ACS: 
100562829
XLA: 
496236(nsdhl)
XTR: 
550044(nsdhl)
DRE: 
550369(nsdhl)
TRU: 
101061359
OLA: 
101171010
BFO: 
BRAFLDRAFT_117175
SPU: 
577670
TAD: 
TRIADDRAFT_56172
AQU: 
100641976
ATH: 
AT1G47290(3BETAHSD/D1)
ALY: 
ARALYDRAFT_473882(AT3BETAHSD/D1) ARALYDRAFT_481483(AT3BETAHSD/D2)
GMX: 
100799363 100816854
MTR: 
MTR_3g105440
CSV: 
101227073
RCU: 
RCOM_0707880
POP: 
POPTR_1081290
VVI: 
100257631
OSA: 
4333071
DOSA: 
Os03t0405000-01(Os03g0405000)
BDI: 
100838723 100841751
SBI: 
SORBI_01g032980(SORBIDRAFT_01g032980) SORBI_02g029890(SORBIDRAFT_02g029890)
ZMA: 
100283692 100383338
SMO: 
SELMODRAFT_129445 SELMODRAFT_84229
PPP: 
PHYPADRAFT_145942
CRE: 
CHLREDRAFT_58501(BHSD1)
VCN: 
VOLCADRAFT_79975
CME: 
CMP217C
SCE: 
YGL001C(ERG26)
AGO: 
AGOS_AFR001W
ERC: 
Ecym_6178
KLA: 
KLLA0C18513g
LTH: 
KLTH0E08338g
PPA: 
PAS_chr1-4_0604
VPO: 
Kpol_1025p36
ZRO: 
ZYRO0G10582g
CGR: 
CAGL0G00594g
NCS: 
NCAS_0A05210(NCAS0A05210)
NDI: 
NDAI_0K02600(NDAI0K02600)
TPF: 
TPHA_0K01550(TPHA0K01550)
TBL: 
TBLA_0E01630(TBLA0E01630)
TDL: 
TDEL_0F02190(TDEL0F02190)
KAF: 
KAFR_0F03320(KAFR0F03320)
DHA: 
DEHA2C11550g
PIC: 
PICST_71224(ERG26)
PGU: 
PGUG_05873
LEL: 
LELG_04583
CAL: 
CaO19.10427(ERG26) CaO19.2909(ERG26)
CTP: 
CTRG_04041
CDU: 
CD36_45790(ERG26)
COT: 
CORT_0E04240
YLI: 
YALI0C22165g
CLU: 
CLUG_01042
NCR: 
NCU02693
SMP: 
SMAC_04350
PAN: 
PODANSg2055
TTT: 
THITE_129164
MTM: 
MYCTH_122939
MGR: 
MGG_11399
FGR: 
FG01203.1
NHE: 
NECHADRAFT_98704
VAL: 
VDBG_04735
SSL: 
SS1G_00993 SS1G_06585 SS1G_08084 SS1G_09117
BFU: 
BC1G_12399 BC1G_16028
ANI: 
AN7575.2 AN8440.2
NFI: 
NFIA_090280 NFIA_098940
AFM: 
AFUA_2G15030 AFUA_2G17400
AOR: 
AOR_1_318094(AO090120000187) AOR_1_724194
ANG: 
ANI_1_470134(An15g03090)
AFV: 
AFLA_016870 AFLA_091760
ACT: 
ACLA_072440 ACLA_081520
PCS: 
Pc12g00300 Pc18g05820
CIM: 
CIMG_02365
CPW: 
CPC735_040060
URE: 
UREG_01388
ABE: 
ARB_03639 ARB_07982
TVE: 
TRV_01960 TRV_04269
AJE: 
HCAG_00257 HCAG_05272
PNO: 
SNOG_03352 SNOG_15264
PTE: 
PTT_14047
ZTR: 
MYCGRDRAFT_32274(ERG26) MYCGRDRAFT_45223 MYCGRDRAFT_67122
TML: 
GSTUM_00005894001
SPO: 
SPBC3F6.02c
CNE: 
CNJ00460
CNB: 
CNBJ3060
CGI: 
CGB_D9350C
PPL: 
POSPLDRAFT_90796 POSPLDRAFT_94333
LBC: 
LACBIDRAFT_188460
MPR: 
MPER_01026 MPER_10147
CCI: 
CC1G_03447
SCM: 
SCHCODRAFT_66672
MGL: 
MGL_3391
PGR: 
PGTG_02889
NGR: 
NAEGRDRAFT_2444
DDI: 
DDB_G0281487
DPP: 
DICPUDRAFT_79373
 » show all
Taxonomy
Reference
1  [PMID:7430141]
  Authors
Brady DR, Crowder RD, Hayes WJ.
  Title
Mixed function oxidases in sterol metabolism. Source of reducing equivalents.
  Journal
J. Biol. Chem. 255 (1980) 10624-9.
Reference
2  [PMID:4401584]
  Authors
Rahimtula AD, Gaylor JL.
  Title
Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.
  Journal
J. Biol. Chem. 247 (1972) 9-15.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:9811880]
  Authors
Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13794-9.
Reference
4  [PMID:14506130]
  Authors
Caldas H, Herman GE
  Title
NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets.
  Journal
Hum. Mol. Genet. 12 (2003) 2981-91.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
71822-23-6
DBGET integrated database retrieval system