KEGG   ENZYME: 1.1.1.170Help
Entry
EC 1.1.1.170                Enzyme                                 

Name
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating);
3beta-hydroxy-4beta-methylcholestenoate dehydrogenase;
sterol 4alpha-carboxylic decarboxylase;
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) (ambiguous);
ERG26 (gene name);
NSDHL (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
Reaction(IUBMB)
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H [RN:R04483 R07149]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid-4alpha-carboxylate;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
The enzyme catalyses the decarboxylation of the C-4 carbon and the dehydrogenation of a 3beta hydroxyl at the C-3 carbon of 3beta-hydroxysteroid-4alpha-carboxylates. It is involved in zymosterol and cholesterol biosynthesis.
History
EC 1.1.1.170 created 1978, modified 2002, modified 2012
Pathway
Steroid biosynthesis
Metabolic pathways
Orthology
K07748  
sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
Genes
HSA: 
50814(NSDHL)
PTR: 
465960(NSDHL)
PPS: 
100975917(NSDHL)
GGO: 
101144867(NSDHL)
PON: 
100172372(NSDHL)
NLE: 
100596441(NSDHL)
MCC: 
693333(NSDHL)
MCF: 
102137627(NSDHL)
CJC: 
100398582(NSDHL)
MMU: 
18194(Nsdhl)
RNO: 
309262(Nsdhl)
CGE: 
HGL: 
101716507(Nsdhl)
TUP: 
102500582(NSDHL)
CFA: 
481079(NSDHL)
AML: 
100466780(NSDHL)
UMR: 
103674163(NSDHL)
FCA: 
101096551(NSDHL)
PTG: 
102959228(NSDHL)
BTA: 
616694(NSDHL)
BOM: 
102276234(NSDHL)
PHD: 
102328837(NSDHL)
CHX: 
102173170(NSDHL)
OAS: 
101112792(NSDHL)
SSC: 
100157894(NSDHL)
CFR: 
102516550(NSDHL)
BACU: 
103020703(NSDHL)
LVE: 
103087463(NSDHL)
ECB: 
100063648(NSDHL)
MYB: 
102257708(NSDHL)
MYD: 
102771848(NSDHL)
PALE: 
102879960(NSDHL)
MDO: 
100026414(NSDHL)
SHR: 
100914940(NSDHL)
OAA: 
103171093(NSDHL)
GGA: 
422302(NSDHL)
MGP: 
APLA: 
101790127(NSDHL)
TGU: 
FAB: 
101814664(NSDHL)
PHI: 
102100867(NSDHL)
FPG: 
101921503(NSDHL)
FCH: 
102048326(NSDHL)
CLV: 
102098029(NSDHL)
ASN: 
102383140(NSDHL)
AMJ: 
102562140(NSDHL)
PSS: 
102447619(NSDHL)
CMY: 
102945577(NSDHL)
ACS: 
100562829(nsdhl)
PBI: 
103061373(NSDHL)
XLA: 
496236(nsdhl)
XTR: 
550044(nsdhl)
DRE: 
550369(nsdhl)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102355835(NSDHL)
CMK: 
103177331(nsdhl)
BFO: 
SPU: 
HRO: 
LGI: 
TAD: 
AQU: 
ATH: 
AT1G47290(3BETAHSD/D1) AT2G26260(3BETAHSD/D2)
ALY: 
ARALYDRAFT_473882(AT3BETAHSD/D1) ARALYDRAFT_481483(AT3BETAHSD/D2)
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0405000-01(Os03g0405000) Os09t0516500-00(Os09g0516500)
OBR: 
BDI: 
SBI: 
SORBI_01g032950(SORBIDRAFT_01g032950) SORBI_01g032960(SORBIDRAFT_01g032960) SORBI_01g032970(SORBIDRAFT_01g032970) SORBI_01g032980(SORBIDRAFT_01g032980) SORBI_01g032990(SORBIDRAFT_01g032990) SORBI_01g033520(SORBIDRAFT_01g033520) SORBI_02g029890(SORBIDRAFT_02g029890)
ZMA: 
SITA: 
PDA: 
ATR: 
s00007p00249450(AMTR_s00007p00249450) s00042p00178940(AMTR_s00042p00178940) s00066p00187670(AMTR_s00066p00187670)
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
SCE: 
YGL001C(ERG26)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A05210(NCAS0A05210)
NDI: 
NDAI_0K02600(NDAI0K02600)
TPF: 
TPHA_0K01550(TPHA0K01550)
TBL: 
TBLA_0E01630(TBLA0E01630)
TDL: 
TDEL_0F02190(TDEL0F02190)
KAF: 
KAFR_0F03320(KAFR0F03320)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.10427(ERG26) CaO19.2909(ERG26)
CTP: 
COT: 
CDU: 
CD36_45790(ERG26)
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_318094(AO090120000187) AOR_1_724194
ANG: 
ANI_1_470134(An15g03090)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
SHS: 
PCO: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT113991(AGABI1DRAFT_113991)
ABV: 
AGABI2DRAFT193828(AGABI2DRAFT_193828)
CPUT: 
SLA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
DDI: 
DPP: 
DFA: 
ACAN: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:7430141]
  Authors
Brady DR, Crowder RD, Hayes WJ.
  Title
Mixed function oxidases in sterol metabolism. Source of reducing equivalents.
  Journal
J. Biol. Chem. 255 (1980) 10624-9.
Reference
2  [PMID:4401584]
  Authors
Rahimtula AD, Gaylor JL.
  Title
Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase.
  Journal
J. Biol. Chem. 247 (1972) 9-15.
Reference
3  [PMID:9811880]
  Authors
Gachotte D, Barbuch R, Gaylor J, Nickel E, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13794-9.
  Sequence
[sce:YGL001C]
Reference
4  [PMID:14506130]
  Authors
Caldas H, Herman GE
  Title
NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets.
  Journal
Hum. Mol. Genet. 12 (2003) 2981-91.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
71822-23-6

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