KEGG   ENZYME: 1.1.1.178Help
Entry
EC 1.1.1.178                Enzyme                                 

Name
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203]
Reaction(KEGG)
Substrate
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:C04405];
NAD+ [CPD:C00003]
Product
2-methylacetoacetyl-CoA [CPD:C03344];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
History
EC 1.1.1.178 created 1981
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K08683  
3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
Genes
HSA: 
3028(HSD17B10)
PTR: 
465649(HSD17B10)
PPS: 
100971848(HSD17B10)
GGO: 
PON: 
100459385(HSD17B10)
MCC: 
700018(HSD17B10)
MCF: 
102123916(HSD17B10)
MMU: 
15108(Hsd17b10)
RNO: 
63864(Hsd17b10)
CGE: 
100757689(Hsd17b10)
HGL: 
101712281(Hsd17b10)
TUP: 
102491700(HSD17B10)
CFA: 
480930(HSD17B10)
AML: 
FCA: 
101090672(HSD17B10)
PTG: 
102956982(HSD17B10)
BTA: 
281809(HSD17B10)
BOM: 
102284367(HSD17B10)
PHD: 
102334835(HSD17B10)
CHX: 
102182021(HSD17B10)
SSC: 
100524293(HSD17B10)
CFR: 
102504376(HSD17B10)
BACU: 
103010500(HSD17B10)
LVE: 
103085758(HSD17B10)
ECB: 
100060335(HSD17B10)
MYB: 
MYD: 
102751672(HSD17B10)
PALE: 
102882756(HSD17B10)
MDO: 
100019657(HSD17B10)
SHR: 
100918332(HSD17B10)
OAA: 
100081790(HSD17B10)
GGA: 
425758(HSD17B10)
MGP: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
ASN: 
102377997(HSD17B10)
AMJ: 
102559608(HSD17B10)
PSS: 
CMY: 
102935413(HSD17B10)
ACS: 
PBI: 
103051793(HSD17B10)
XLA: 
446903(hsd17b10)
XTR: 
549265(hsd17b10)
DRE: 
450078(hsd17b10)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102359593(HSD17B10)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
725274(GB13680)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06017(Cbr-ard-1)
BMY: 
LOA: 
SMM: 
NVE: 
TAD: 
AQU: 
MBR: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:4150713]
  Authors
Conrad RS, Massey LK, Sokatch JR.
  Title
D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida.
  Journal
J. Bacteriol. 118 (1974) 103-11.
  Organism
Pseudomonas putida
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-66-4

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