| Entry |
|
|---|
| Name |
3-hydroxy-2-methylbutyryl-CoA dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase;
2-methyl-3-hydroxy-butyryl CoA dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase |
|---|
| Reaction(IUBMB) |
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ =
2-methylacetoacetyl-CoA + NADH + H+ [RN:R04203] |
|---|
| Reaction(KEGG) |
R04203
 |
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| Substrate |
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA [CPD:C04405];
NAD+ [CPD:C00003] |
|---|
| Product |
2-methylacetoacetyl-CoA [CPD:C03344];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA. |
|---|
| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation |
|---|
| Orthology |
KO: K08683 3-hydroxyacyl-CoA dehydrogenase /
3-hydroxy-2-methylbutyryl-CoA dehydrogenase |
|---|
| Genes |
HSA: 3028(HSD17B10)
PTR: 465649(HSD17B10)
MCC: 700018(HSD17B10)
MMU: 15108(Hsd17b10)
RNO: 63864(Hsd17b10)
CFA: 480930(HSD17B10)
BTA: 281809(HSD17B10)
ECB: 100060335
MDO: 100019657
OAA: 100081790
GGA: 425758(HSD17B10)
TGU: 100228698
XLA: 446903(hadh2)
XTR: 549265(hadh2)
DRE: 450078(hsd17b10)
BFO: BRAFLDRAFT_291364
CIN: 100180343
SPU: 579135
DME: Dmel_CG7113(scu)
DPO: Dpse_GA20113
DAN: Dana_GF19368
DER: Dere_GG19147
DPE: Dper_GL14944
DSE: Dsec_GM22877
DSI: Dsim_GD17383
DYA: Dyak_GE17707
DGR: Dgri_GH24783
DMO: Dmoj_GI14682
AGA: AgaP_AGAP003414
AAG: AaeL_AAEL009324
CQU: CpipJ_CPIJ014285
AME: 725274
NVI: 100114736
TCA: 660648
API: 100164493
ISC: IscW_ISCW018873
CEL: F01G4.2(ard-1)
CBR: CBG06017
BMY: Bm1_06360
SMM: Smp_151030
NVE: NEMVE_v1g163220
TAD: TRIADDRAFT_22420 TRIADDRAFT_51183
MBR: MONBRDRAFT_35161
TPS: THAPS_263178(HCD1)
 |
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| Structures |
PDB: 2O23 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4150713]
Conrad RS, Massey LK, Sokatch JR.
D- and L-isoleucine metabolism and regulation of their pathways in
Pseudomonas putida.
J. Bacteriol. 118 (1974) 103-11.
Pseudomonas putida |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.178
IUBMB Enzyme Nomenclature: 1.1.1.178
ExPASy - ENZYME nomenclature database: 1.1.1.178
BRENDA, the Enzyme Database: 1.1.1.178
CAS: 52227-66-4 |
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