| Entry |
|
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| Name |
inositol 2-dehydrogenase;
myo-inositol 2-dehydrogenase;
myo-inositol:NAD+ oxidoreductase;
inositol dehydrogenase;
myo-inositol dehydrogenase |
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
myo-inositol:NAD+ 2-oxidoreductase |
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| Reaction(IUBMB) |
myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH +
H+ [RN:R01183] |
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| Reaction(KEGG) |
R01183
 |
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| Substrate |
myo-inositol [CPD:C00137];
NAD+ [CPD:C00003] |
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| Product |
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691];
NADH [CPD:C00004];
H+ [CPD:C00080] |
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| Pathway |
PATH: ec00521 Streptomycin biosynthesis
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00010 myo-inositol 2-dehydrogenase |
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| Genes |
CIN: 100178609
CME: CMF086C CMR475C
DHA: DEHA0F23441g
PIC: PICST_64256 PICST_78306
FGR: FG04702.1 FG08414.1
ANI: AN5984.2
AFM: AFUA_2G10240
AOR: AO090011000611 AO090011000612
ANG: An09g01970 An16g04750
AFV: AFLA_044390
PCS: Pc22g20320
NFI: NFIA_085630
CNB: CNBC0340 CNBI0030
ECQ: ECED1_0304(iolG) ECED1_0315
SPQ: SPAB_05572 SPAB_05582
SEA: SeAg_B4707 SeAg_B4715
STM: STM4425 STM4433
YPA: YPA_2521 YPA_2522
YPN: YPN_1063 YPN_1064
YPP: YPDSF_2674 YPDSF_2675
YPS: YPTB1073
YPI: YpsIP31758_2974
YPY: YPK_3046
YPB: YPTS_1129
YEN: YE4026(idh)
ECA: ECA1458(idhA)
PCT: PC1_1336
PWA: Pecwa_1046 Pecwa_3001
ETA: ETA_32880(iolG)
PLU: plu1804
PAY: PAU_02711(idhA)
CTU: Ctu_08980(iolG)
KPN: KPN_00507 KPN_04675
KPE: KPK_4081(idhA) KPK_4990(idh)
KPU: KP1_0560 KP1_1420
CKO: CKO_03991
SPE: Spro_2393 Spro_4658
EIC: NT01EI_2135
DDC: Dd586_0708
DZE: Dd1591_3339
HAP: HAPS_1534(iolG)
HSO: HS_1576(iolG)
HSM: HSM_0435
AAP: NT05HA_1322
AAT: D11S_1813
PPR: PBPRB0470
PST: PSPTO_3047 PSPTO_3494(iolG)
PSB: Psyr_3268
PSP: PSPPH_2336 PSPPH_3188(iolG)
PFL: PFL_2591
PFS: PFLU2385 PFLU2580
AVN: Avin_09420 Avin_31420 Avin_50110(idh)
LPN: lpg1652
LPF: lpl1618(iolG)
LPP: lpp1623(iolG)
LPC: LPC_1082(iolG)
HCH: HCH_05773
MMW: Mmwyl1_1599
RSO: RSc1246(iolG)
BMA: BMA0918
BMV: BMASAVP1_A1449 BMASAVP1_A1451
BML: BMA10229_A0430 BMA10229_A0431
BMN: BMA10247_0731 BMA10247_0732
BPS: BPSL1988 BPSL1989
BPM: BURPS1710b_1836(idhA) BURPS1710b_1838
BPL: BURPS1106A_1682 BURPS1106A_1683
BPD: BURPS668_1660 BURPS668_1661
BPR: GBP346_A1705 GBP346_A1706
BTE: BTH_I2641 BTH_I2642
BVI: Bcep1808_1391
BUR: Bcep18194_A4572 Bcep18194_A6014
BCN: Bcen_0946 Bcen_2075
BCH: Bcen2424_1428 Bcen2424_2686
BCM: Bcenmc03_1406 Bcenmc03_2715
BCJ: BCAL0917 BCAL1435(idh)
BAM: Bamb_1308 Bamb_2740 Bamb_3338
BAC: BamMC406_1347
BMU: Bmul_0611 Bmul_1887
BMJ: BMULJ_01354(iolG) BMULJ_02649(iolG)
BXE: Bxe_A1331 Bxe_A1332
BPH: Bphy_1594 Bphy_1595
BPY: Bphyt_2803 Bphyt_2804
BGL: bglu_1g21980 bglu_1g21990
VEI: Veis_0056 Veis_1850
DAC: Daci_2925
LCH: Lcho_0840 Lcho_2412 Lcho_3282 Lcho_3283
MLO: mll1000 mll4991
SME: SM_b20899(idhA)
SMD: Smed_0190 Smed_4469
ATU: Atu4012(idhA) Atu4554(iolG)
ATC: AGR_L_1682 AGR_L_628
ARA: Arad_0103(idhA) Arad_0116 Arad_3362(idhA) Arad_8534(idhA)
AVI: Avi_0074(idhA)
RET: RHE_CH01209(ypch00405) RHE_CH02357(ypch00774) RHE_CH03170(idhA)
REC: RHECIAT_CH0003391(idhA) RHECIAT_PC0000701
RLE: RL3622
RLT: Rleg2_2918 Rleg2_4853
RLG: Rleg_3183 Rleg_5295
RHI: NGR_c24190(idhA2) NGR_c26010(iolG)
BME: BMEII0574
BMI: BMEA_B0686
BMF: BAB2_0528
BMB: BruAb2_0519(idhA)
BMC: BAbS19_II04980
BMS: BRA0711(idhA)
BMT: BSUIS_B0698
BOV: BOV_A0667(idhA)
BCS: BCAN_B0716(mocA)
BMR: BMI_II705(idhA)
OAN: Oant_3835
BRA: BRADO2244(idhA)
BBT: BBta_0488(idhA)
MNO: Mnod_7807
BID: Bind_2828
CCR: CC_1296
CCS: CCNA_01354(idhA)
SIT: TM1040_3352
RSP: RSP_3283 RSP_3670
RSH: Rsph17029_3405 Rsph17029_4015
RSK: RSKD131_3457 RSKD131_3900
JAN: Jann_1416
RDE: RD1_0217(idhA) RD1_3876
PDE: Pden_1678
DSH: Dshi_1265(idhA)
GOX: GOX1187
ACR: Acry_2320 Acry_2329
GDI: GDI_0366(idhA)
GDJ: Gdia_2417
BSU: BSU27770(yrbE) BSU39700(iolG)
BHA: BH2220 BH2221 BH2316(iolG)
BAN: BA2511
BAR: GBAA2511
BAA: BA_3002
BAT: BAS2332
BAH: BAMEG_2091
BAI: BAA_2567
BCZ: BCZK2251 pE33L466_0294(iolG) pE33L466_0299(iolG)
BCU: BCAH820_2526
BCX: BCA_2596
BTK: BT9727_2295
BTL: BALH_2257
BLI: BL00240(idh) BL01338(yisS)
BLD: BLi01181(yisS) BLi04245(idh)
BCL: ABC0427(iolG) ABC0429
BAY: RBAM_036720(iolG)
GKA: GK1897
GTN: GTNG_1811 GTNG_1817
GYM: GYMC10_3672
BBE: BBR47_17140
PJD: Pjdr2_1952
LPL: lp_3605(iolG1) lp_3606(iolG2) lp_3608(iolG3) lp_3612(iolG4)
LCB: LCABL_02210(iolG1) LCABL_02220(iolG2)
LRH: LGG_00266(iolG1) LGG_00267(iolG2)
LRL: LC705_00257(iolG1) LC705_00258(iolG2)
CPE: CPE0090 CPE0093
CPF: CPF_0085 CPF_0088
CTC: CTC00511 CTC00513
CBK: CLL_A1305
CBT: CLH_1256
CBE: Cbei_4547
CSC: Csac_2738
MHY: mhp144 mhp150
MHJ: MHJ_0222 MHJ_0228
MHP: MHP7448_0228 MHP7448_0235
MSM: MSMEG_4650 MSMEG_4666
MVA: Mvan_0387 Mvan_3968 Mvan_4020
MGI: Mflv_2598 Mflv_2613
CGL: NCgl0161(cgl0164) NCgl2029(cgl2110) NCgl2957(cgl3062)
NCgl2958(cgl3063)
CGB: cg0204(iolG) cg2313(idhA3) cg3391(idhA1) cg3392(idhA2)
CGT: cgR_0243 cgR_1994 cgR_2947 cgR_2948
RHA: RHA1_ro01355 RHA1_ro02992 RHA1_ro03886 RHA1_ro05267
RER: RER_20160(idh) RER_20290(idh) RER_20320 RER_20390
ROP: ROP_05130(idh) ROP_05170(idh) ROP_10710 ROP_37550(idh)
ROP_53120
GBR: Gbro_1982 Gbro_3594 Gbro_3609
SCO: SCO6255(SCAH10.20c) SCO6984(SC8F11.10c) SCO7254(SC5H1.38)
SMA: SAV_1234(iolG) SAV_1985 SAV_7188
SGR: SGR_1277 SGR_5937(strI)
LXX: Lxx24320
CMI: CMM_0793
ART: Arth_0825 Arth_0833 Arth_0834
AAU: AAur_1982 AAur_1991 AAur_1993 AAur_1994
ACH: Achl_0120 Achl_0146 Achl_0942
RSA: RSal33209_0365 RSal33209_3165
BCV: Bcav_0731 Bcav_1659
BFA: Bfae_00380
PAC: PPA0469
SRO: Sros_5561 Sros_8496
FRA: Francci3_3374
ACE: Acel_1805 Acel_1809 Acel_1814
NML: Namu_1848 Namu_3353 Namu_4534
KRA: Krad_0031 Krad_0276 Krad_4051 Krad_4156
SEN: SACE_2980(iolG) SACE_3276(idhA2) SACE_4537(iolG)
SACE_4657(iolG) SACE_5193(iolG)
AMI: Amir_6853
STP: Strop_2344
SAQ: Sare_1242 Sare_2488
CAI: Caci_4486
RXY: Rxyl_1723 Rxyl_1727
SUS: Acid_1485 Acid_4014
DFE: Dfer_5698
STR: Sterm_4008 Sterm_4014
AVA: Ava_0798
DDR: Deide_3p01930
TMA: TM0414
TPT: Tpet_0506
TNA: CTN_0255
TNP: Tnap_0206
KOL: Kole_0987
TTR: Tter_1526
CMA: Cmaq_0681
TPE: Tpen_1013
 |
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| Structures |
PDB: 3CEA 3EUW |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:5905122]
Berman T, Magasanik B.
The pathway of myo-inositol degradation in Aerobacter aerogenes.
Dehydrogenation and dehydration.
J. Biol. Chem. 241 (1966) 800-6.
Klebsiella pneumoniae [GN:kpn] |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:13292912]
LARNER J, JACKSON WT, GRAVES DJ, STAMER JR.
Inositol dehydrogenase from Aerobacter aerogenes.
Arch. Biochem. Biophys. 60 (1956) 352-63.
Klebsiella pneumoniae [GN:kpn] |
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Reference
Authors
Title
Journal
Organism
|
3 [PMID:4351258]
Vidal-Leiria M, van Uden N.
Inositol dehydrogenase from the yeast Cryptococcus melibiosum.
Biochim. Biophys. Acta. 293 (1973) 295-303.
Cryptococcus melibiosum |
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| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.18
IUBMB Enzyme Nomenclature: 1.1.1.18
ExPASy - ENZYME nomenclature database: 1.1.1.18
BRENDA, the Enzyme Database: 1.1.1.18
CAS: 9028-25-5 |
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