KEGG   ENZYME: 1.1.1.181Help
Entry
EC 1.1.1.181                Enzyme                                 

Name
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase
Reaction(IUBMB)
cholest-5-ene-3beta,7alpha-diol + NAD+ = 7alpha-hydroxycholest-4-en-3-one + NADH + H+ [RN:R04263]
Reaction(KEGG)
Substrate
cholest-5-ene-3beta,7alpha-diol [CPD:C03594];
NAD+ [CPD:C00003]
Product
7alpha-hydroxycholest-4-en-3-one [CPD:C05455];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Highly specific for 3beta-hydroxy-C27-steroids with Delta5-double bond.
History
EC 1.1.1.181 created 1983
Pathway
Primary bile acid biosynthesis
Metabolic pathways
Orthology
K12408  
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
Genes
HSA: 
80270(HSD3B7)
PTR: 
454059(HSD3B7)
PPS: 
100986476(HSD3B7)
GGO: 
101148659(HSD3B7)
PON: 
100460204(HSD3B7)
MCC: 
MCF: 
102133533(HSD3B7)
CJC: 
100385140(HSD3B7)
MMU: 
101502(Hsd3b7)
RNO: 
246211(Hsd3b7)
CGE: 
100754260(Hsd3b7)
NGI: 
103726335(Hsd3b7)
HGL: 
101708818(Hsd3b7)
OCU: 
100353878(HSD3B7)
TUP: 
102492683(HSD3B7)
CFA: 
489917(HSD3B7)
AML: 
UMR: 
103657879(HSD3B7)
FCA: 
101090824(HSD3B7)
PTG: 
102962469(HSD3B7)
BTA: 
540229(HSD3B7)
BOM: 
102274613(HSD3B7)
PHD: 
102325068(HSD3B7)
CHX: 
102170750(HSD3B7)
OAS: 
101105716(HSD3B7)
SSC: 
100525281(HSD3B7)
CFR: 
102516280(HSD3B7)
BACU: 
102999563(HSD3B7)
LVE: 
103079291(HSD3B7)
ECB: 
100063491(HSD3B7)
MYB: 
102253555(HSD3B7)
MYD: 
102773587(HSD3B7)
PALE: 
102884924(HSD3B7)
MDO: 
100018964(HSD3B7)
SHR: 
100929800(HSD3B7)
OAA: 
100086824(HSD3B7)
GGA: 
417505(HSD3B7)
MGP: 
APLA: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
102370034(HSD3B7)
AMJ: 
102574351(HSD3B7)
PSS: 
CMY: 
ACS: 
100555869(hsd3b7)
PBI: 
103058949(HSD3B7)
XLA: 
XTR: 
DRE: 
327462(hsd3b7)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
 » show all
Taxonomy
Reference
1  [PMID:6937465]
  Authors
Wikvall K.
  Title
Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit liver microsomes.
  Journal
J. Biol. Chem. 256 (1981) 3376-80.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56626-16-5

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