| Entry |
|
|---|
| Name |
cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase;
3beta-hydroxy-Delta5-C27-steroid oxidoreductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase |
|---|
| Reaction(IUBMB) |
cholest-5-ene-3beta,7alpha-diol + NAD+ =
7alpha-hydroxycholest-4-en-3-one + NADH + H+ [RN:R04263] |
|---|
| Reaction(KEGG) |
R04263 > R08721 R08723 R08724 R08728;
(other) R04264
 |
|---|
| Substrate |
cholest-5-ene-3beta,7alpha-diol [CPD:C03594];
NAD+ [CPD:C00003] |
|---|
| Product |
7alpha-hydroxycholest-4-en-3-one [CPD:C05455];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Highly specific for 3beta-hydroxy-C27-steroids with Delta5-double
bond. |
|---|
| Pathway |
PATH: ec00120 Primary bile acid biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K12408 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase |
|---|
| Genes |
HSA: 80270(HSD3B7)
PTR: 454059(HSD3B7)
MMU: 101502(Hsd3b7)
RNO: 246211(Hsd3b7)
CFA: 489917(HSD3B7)
BTA: 540229(HSD3B7)
ECB: 100063491
MDO: 100018964
OAA: 100086824
GGA: 417505(HSD3B7)
XLA: 431878
XTR: 100145626
DRE: 327462(hsd3b7)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6937465]
Wikvall K.
Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid
oxidoreductase from rabbit liver microsomes.
J. Biol. Chem. 256 (1981) 3376-80.
Oryctolagus cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.181
IUBMB Enzyme Nomenclature: 1.1.1.181
ExPASy - ENZYME nomenclature database: 1.1.1.181
BRENDA, the Enzyme Database: 1.1.1.181
CAS: 56626-16-5 |
|---|
