| Entry |
|
|---|
| Name |
GDP-4-dehydro-D-rhamnose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase;
GDP-4-keto-D-rhamnose reductase;
guanosine diphosphate-4-keto-D-rhamnose reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase |
|---|
| Reaction(IUBMB) |
GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose +
NAD(P)H + H+ [RN:R03397 R03399] |
|---|
| Reaction(KEGG) |
R03397 R03399
 |
|---|
| Substrate |
GDP-6-deoxy-D-mannose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
GDP-4-dehydro-6-deoxy-D-mannose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4
epimer is formed. |
|---|
| Pathway |
PATH: ec00051 Fructose and mannose metabolism
PATH: ec00520 Amino sugar and nucleotide sugar metabolism |
|---|
| Orthology |
KO: K00080 GDP-4-dehydro-D-rhamnose reductase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4386238]
Barber GA.
The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a
higher plant.
Biochim. Biophys. Acta. 165 (1968) 68-75.
Leucaena glauca |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4398966]
Winkler NW, Markovitz A.
Guanosine diphosphate-4-keto-D-rhamnose reductase. A
non-stereoselective enzyme.
J. Biol. Chem. 246 (1971) 5868-76.
soil bacterium GS |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.187
IUBMB Enzyme Nomenclature: 1.1.1.187
ExPASy - ENZYME nomenclature database: 1.1.1.187
BRENDA, the Enzyme Database: 1.1.1.187
CAS: 9075-56-3 |
|---|
