KEGG   ENZYME: 1.1.1.2Help
Entry
EC 1.1.1.2                  Enzyme                                 

Name
alcohol dehydrogenase (NADP+);
aldehyde reductase (NADPH2);
NADP-alcohol dehydrogenase;
NADP+-aldehyde reductase;
NADP+-dependent aldehyde reductase;
NADPH-aldehyde reductase;
NADPH-dependent aldehyde reductase;
nonspecific succinic semialdehyde reductase;
ALR 1;
low-Km aldehyde reductase;
high-Km aldehyde reductase;
alcohol dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
alcohol:NADP+ oxidoreductase
Reaction(IUBMB)
an alcohol + NADP+ = an aldehyde + NADPH + H+ [RN:R07328]
Reaction(KEGG)
Substrate
alcohol [CPD:C00069];
NADP+ [CPD:C00006]
Product
aldehyde [CPD:C00071];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
A zinc protein. Some members of this group oxidize only primary alcohols; others act also on secondary alcohols. May be identical with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate reductase (NADPH)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH)]. Re-specific with respect to NADPH.
History
EC 1.1.1.2 created 1961
Pathway
Glycolysis / Gluconeogenesis
Pentose and glucuronate interconversions
Glycerolipid metabolism
Caprolactam degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00002  
alcohol dehydrogenase (NADP+)
Genes
HSA: 
10327(AKR1A1)
PTR: 
741418(AKR1A1)
PPS: 
100990701(AKR1A1)
GGO: 
101124639(AKR1A1)
PON: 
100173796(AKR1A1)
MCC: 
693380(AKR1A1)
MCF: 
102143796(AKR1A1)
MMU: 
58810(Akr1a1)
RNO: 
78959(Akr1a1)
CGE: 
100689106(Akr1a1)
HGL: 
101710959(Akr1a1)
TUP: 
102474258(AKR1A1)
CFA: 
610537(AKR1A1)
AML: 
FCA: 
101091464(AKR1A1)
PTG: 
102953655(AKR1A1)
BTA: 
618607(AKR1A1)
BOM: 
102278148(AKR1A1)
PHD: 
102329994(AKR1A1)
CHX: 
102181747(AKR1A1)
SSC: 
396924(AKR1A1)
CFR: 
102508336(AKR1A1)
ECB: 
100052360(AKR1A1)
MYB: 
102261432(AKR1A1)
MYD: 
102763234(AKR1A1)
PALE: 
102889346(AKR1A1)
MDO: 
100024617(AKR1A1)
SHR: 
100933920(AKR1A1)
OAA: 
100076515(AKR1A1)
GGA: 
424599(AKR1A1)
MGP: 
TGU: 
100220342(AKR1A1)
FAB: 
101814677(AKR1A1)
PHI: 
102111381(AKR1A1)
APLA: 
101804381(AKR1A1)
FPG: 
101914281(AKR1A1)
FCH: 
102058485(AKR1A1)
CLV: 
102086095(AKR1A1)
ASN: 
102381941(AKR1A1)
PSS: 
102453813(AKR1A1)
CMY: 
102932885(AKR1A1)
ACS: 
XLA: 
444488(akr1a1)
XTR: 
548891(akr1a1)
DRE: 
445326(akr1a1a) 799805(akr1a1b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
SPU: 
DME: 
NVE: 
HMG: 
TAD: 
AQU: 
CME: 
GSL: 
SCE: 
YCR105W(ADH7) YMR318C(ADH6)
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0C03020(NCAS0C03020) NCAS_0D01220(NCAS0D01220)
NDI: 
NDAI_0A08470(NDAI0A08470) NDAI_0G04880(NDAI0G04880) NDAI_0H02940(NDAI0H02940) NDAI_0H02950(NDAI0H02950)
TPF: 
TPHA_0A00140(TPHA0A00140)
TBL: 
TBLA_0A02730(TBLA0A02730) TBLA_0A06640(TBLA0A06640)
TDL: 
TDEL_0E00230(TDEL0E00230)
KAF: 
KAFR_0A08730(KAFR0A08730) KAFR_0C01550(KAFR0C01550)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_1328154(AO090003000751) AOR_1_780144(AO090023000460)
ANG: 
ANI_1_358144(An16g02510)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
PNO: 
PTE: 
ZTR: 
TML: 
CNE: 
CNB: 
CGI: 
PPL: 
CCI: 
UMA: 
PGR: 
MBR: 
EHI: 
EHI_023110(81.t00034) EHI_039190(73.t00013) EHI_198760(34.t00053)
EDI: 
ACAN: 
PTI: 
TPS: 
PIF: 
TCR: 
LMA: 
TVA: 
CBD: 
CBG: 
ABO: 
ABO_2414(AKR1A1)
ABU: 
DPR: 
CCE: 
SYN: 
SYG: 
CYT: 
PPN: 
SRU: 
SRM: 
CMR: 
MTT: 
GFO: 
ZPR: 
CAT: 
MAC: 
MBA: 
MST: 
HMA: 
pNG7101(adh8)
HWA: 
HQ1729A(adh)
 » show all
Taxonomy
Reference
1  [PMID:4402936]
  Authors
Bosron WF, Prairie RL.
  Title
Triphosphopyridine nucleotide-linked aldehyde reductase. I. Purification and properties of the enzyme from pig kidney cortex.
  Journal
J. Biol. Chem. 247 (1972) 4480-5.
  Organism
Sus scrofa
Reference
2
  Authors
DeMoss, R.
  Title
Triphosphopyridine nucleotide-specific ethanol dehydrogenase from Leuconostoc mesenteroides.
  Journal
Bacteriol. Proc. (1953) 81.
Reference
3
  Authors
Reeves, R.E., Montalvo, F.E. and Lushbaugh, T.S.
  Title
Nicotinamide-adenine dinucleotide phosphate-dependent alcohol dehydrogenase. Enzyme from Entamoeba histolytica and some enzyme inhibitors.
  Journal
Int. J. Biochem. 2 (1971) 55-64.
Reference
4  [PMID:4393513]
  Authors
Tabakoff B, Erwin VG.
  Title
Purification and characterization of a reduced nicotinamide adenine dinucleotide phosphate-linked aldehyde reductase from brain.
  Journal
J. Biol. Chem. 245 (1970) 3263-8.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-12-0

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