KEGG   ENZYME: 1.1.1.2Help
Entry
EC 1.1.1.2                  Enzyme                                 
Name alcohol dehydrogenase (NADP+);
aldehyde reductase (NADPH2);
NADP-alcohol dehydrogenase;
NADP+-aldehyde reductase;
NADP+-dependent aldehyde reductase;
NADPH-aldehyde reductase;
NADPH-dependent aldehyde reductase;
nonspecific succinic semialdehyde reductase;
ALR 1;
low-Km aldehyde reductase;
high-Km aldehyde reductase;
alcohol dehydrogenase (NADP+)
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname alcohol:NADP+ oxidoreductase
Reaction(IUBMB) an alcohol + NADP+ = an aldehyde + NADPH + H+ [RN:R07328]
Reaction(KEGG) R07328 > R00625 R00746 R01041 R05231
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Substrate alcohol [CPD:C00069];
NADP+ [CPD:C00006]
Product aldehyde [CPD:C00071];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Cofactor Zinc [CPD:C00038]
Comment A zinc protein. Some members of this group oxidize only primary
alcohols; others act also on secondary alcohols. May be identical
with EC 1.1.1.19 (L-glucuronate reductase), EC 1.1.1.33 [mevaldate
reductase (NADPH)] and EC 1.1.1.55 [lactaldehyde reductase (NADPH)].
A-specific with respect to NADPH.
Pathway PATH: ec00010  Glycolysis / Gluconeogenesis
PATH: ec00561  Glycerolipid metabolism
PATH: ec00930  Caprolactam degradation
PATH: ec01100  Metabolic pathways
Orthology KO: K00002  alcohol dehydrogenase (NADP+)
Genes HSA: 10327(AKR1A1)
PTR: 741418(AKR1A1)
MCC: 693380(AKR1A1)
MMU: 58810(Akr1a4)
RNO: 78959(Akr1a1)
CFA: 610537
BTA: 618607(AKR1A1)
SSC: 396924(ALR1)
ECB: 100052360
MDO: 100024617
OAA: 100076515
GGA: 424599(AKR1A1)
TGU: 100220342
XLA: 444488
XTR: 548891(TEgg056i02.1)
DRE: 799805(akr1a1b)
SPU: 587281
DME: Dmel_CG2767
NVE: NEMVE_v1g181888
OSA: 4338987(Os05g0456300)
CME: CMM296C
KLA: KLLA0E19987g
DHA: DEHA0C05126g DEHA0C18986g
PIC: PICST_29079(ADH4) PICST_45137(ADH7)
CGR: CAGL0H06853g CAGL0M14047g
NCR: NCU04823 NCU11179
MGR: MGG_11818
ANI: AN2860.2
AFM: AFUA_1G09750 AFUA_3G11900 AFUA_6G10260
AOR: AO090003000751 AO090023000460
CNE: CNC05140 CNK02370
UMA: UM01861.1
EHI: EHI_023110 EHI_039190
TET: TTHERM_00274500
TCR: 504339.19 504425.60 508677.80 509331.210
LMA: LmjF23.0360
TVA: TVAG_344880
SPE: Spro_4441
XFA: XF1136 XF1727 XF1734
XFT: PD0423(adhP)
XCC: XCC0029(yahK)
XCB: XC_0029
XCA: xccb100_0032(mtdH)
XCV: XCV0034
XAC: XAC0031(yahK)
XOO: XOO0280(yahK)
XOM: XOO_0252
PAE: PA2275
PPU: PP_2426
PST: PSPTO_2182 PSPTO_2697
PSB: Psyr_1992 Psyr_2431
PSP: PSPPH_1961 PSPPH_2589
PFL: PFL_1816 PFL_2420
PFO: Pfl01_4120
PSA: PST_3017
SAZ: Sama_2709
SLO: Shew_3048
SHN: Shewana3_1694
ILO: IL1440
PAT: Patl_1426
CBD: CBUD_1937
CBG: CbuG_1847
LPN: lpg0612
LPF: lpl0647
LPP: lpp0663
LPC: LPC_2686
NOC: Noc_0435
ABO: ABO_2414(AKR1A1)
AFE: Lferr_0972
AFR: AFE_0846
CVI: CV_2051
RSO: RS05494(RSp1124) RSc0632
BMA: BMA3240
BMV: BMASAVP1_A2898
BML: BMA10229_A2188
BMN: BMA10247_3447
BPS: BPSL0192(adhC)
BPM: BURPS1710b_0372(adhC)
BPL: BURPS1106A_0187
BPD: BURPS668_0177
BTE: BTH_I0152
BVI: Bcep1808_3188
BCJ: BCAL0488
BMJ: BMULJ_00130(adh)
BXE: Bxe_B1754
RFR: Rfer_2439
HPY: HP1104
HPJ: jhp1030 jhp1429
HPA: HPAG1_1042
HHE: HH1166(cad)
HAC: Hac_0437(adhA)
CJE: Cj1548c
CJR: CJE1719
CJJ: CJJ81176_1533
BBA: Bd0900(adhA)
SME: SMc00680
ATU: Atu2022(adh)
ATC: AGR_C_3663A
RET: RHE_CH02758(adh)
RLE: RL3212
RPE: RPE_2083
MMR: Mmar10_2303
GBE: GbCGDNIH1_2346
GDI: GDI_2530(adhC)
BLI: BL05196(adhA)
BLD: BLi02097(adhA)
OIH: OB0786
MPE: MYPE5230(adhA)
MTU: Rv3045(adhC)
MTC: MT3130(adh)
MRA: MRA_3077(adhC)
MBO: Mb3071(adhC)
MBB: BCG_3069(adhC)
MLE: ML1730(adhA)
MPA: MAP3093(adhC)
MAV: MAV_3911
MSM: MSMEG_1037 MSMEG_2317
MUL: MUL_1885(adh)
MVA: Mvan_2080
MGI: Mflv_4279
MAB: MAB_3400
MMC: Mmcs_1836
MJL: Mjls_1817
CGL: NCgl0324(cgl0331)
CGB: cg0400(adhC)
CGT: cgR_0413
CEF: CE0149 CE0338
CJK: jk2055(adhA)
NFA: nfa52260
RHA: RHA1_ro02119
SCO: SCO4945(2SCK31.05)
SMA: SAV_3314(adhA4)
CMI: CMM_0662(adhA)
ART: Arth_0255 Arth_2634
AAU: AAur_2040 AAur_2625
RSA: RSal33209_1408
KRH: KRH_19860(adhC)
PAC: PPA1072
SEN: SACE_1843(adhA) SACE_2652
LIL: LA3172
LIC: LIC10949(dkgA)
ABA: Acid345_1946
SRU: SRU_1267
GFO: GFO_1874
SYN: slr0942
CYT: cce_0782
AVA: Ava_2489
MAC: MA0403 MA1901(adh)
MBA: Mbar_A0771
MST: Msp_0967(adh)
HMA: pNG7101(adh8)
HWA: HQ1729A(adh)
Taxonomy
Structures PDB: 1AE4  1BXZ  1C9W  1CWN  1HQT  1JQB  1KEV  1NXQ  1P0C  1P0F  
     1PED  1UJM  1Y1P  1Y9A  1YKF  1ZJY  1ZJZ  1ZK0  1ZK1  1ZK2  
     1ZK3  1ZK4  1ZZE  2ALR  2B83  2NVB  2OUI  3CV7  3FPC  3FPL  
     3FSR  3FTN  3FX4  3GVX  3H4G  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4402936]
Bosron WF, Prairie RL.
Triphosphopyridine nucleotide-linked aldehyde reductase. I.
Purification and properties of the enzyme from pig kidney cortex.
J. Biol. Chem. 247 (1972) 4480-5.
Sus scrofa [GN:ssc]
Reference
  Authors
  Title

  Journal
 2
DeMoss, R.
Triphosphopyridine nucleotide-specific ethanol dehydrogenase from
Leuconostoc mesenteroides.
Bacteriol. Proc. (1953) 81.
Reference
  Authors
  Title


  Journal
 3
Reeves, R.E., Montalvo, F.E. and Lushbaugh, T.S.
Nicotinamide-adenine dinucleotide phosphate-dependent alcohol
dehydrogenase. Enzyme from Entamoeba histolytica and some enzyme
inhibitors.
Int. J. Biochem. 2 (1971) 55-64.
Reference
  Authors
  Title

  Journal
  Organism
 4  [PMID:4393513]
Tabakoff B, Erwin VG.
Purification and characterization of a reduced nicotinamide adenine
dinucleotide phosphate-linked aldehyde reductase from brain.
J. Biol. Chem. 245 (1970) 3263-8.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.2
IUBMB Enzyme Nomenclature: 1.1.1.2
ExPASy - ENZYME nomenclature database: 1.1.1.2
BRENDA, the Enzyme Database: 1.1.1.2
CAS: 9028-12-0
DBGET integrated database retrieval system