KEGG   ENZYME: 1.1.1.211Help
Entry
EC 1.1.1.211                Enzyme                                 

Name
long-chain-3-hydroxyacyl-CoA dehydrogenase;
beta-hydroxyacyl-CoA dehydrogenase;
long-chain 3-hydroxyacyl coenzyme A dehydrogenase;
3-hydroxyacyl-CoA dehydrogenase;
LCHAD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+ [RN:R01778]
Reaction(KEGG)
Substrate
long-chain (S)-3-hydroxyacyl-CoA;
NAD+ [CPD:C00003]
Product
long-chain 3-oxoacyl-CoA;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).
History
EC 1.1.1.211 created 1986
Pathway
Fatty acid elongation
Fatty acid degradation
Biosynthesis of unsaturated fatty acids
Metabolic pathways
Orthology
K07515  
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
K10527  
enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
Genes
HSA: 
3030(HADHA)
PTR: 
459079(HADHA)
PPS: 
100978217(HADHA)
GGO: 
101143053(HADHA)
PON: 
100172963(HADHA)
NLE: 
100593233(HADHA)
MCC: 
695975(HADHA)
MCF: 
102142372(HADHA)
CJC: 
100390439(HADHA)
MMU: 
97212(Hadha)
RNO: 
170670(Hadha)
CGE: 
100757947(Hadha)
HGL: 
101724137(Hadha)
TUP: 
CFA: 
100856745(HADHA)
AML: 
100469654(HADHA)
UMR: 
103671672(HADHA)
FCA: 
101084701(HADHA)
PTG: 
102966470(HADHA)
BTA: 
281810(HADHA)
BOM: 
102287426(HADHA)
PHD: 
102332095(HADHA)
CHX: 
102189046(HADHA)
OAS: 
100192316(HADHA)
SSC: 
397012(HADHA)
CFR: 
102516648(HADHA)
BACU: 
103001885(HADHA)
LVE: 
103086620(HADHA)
ECB: 
100071381(HADHA)
MYB: 
102263028(HADHA)
MYD: 
102751724(HADHA)
PALE: 
102889313(HADHA)
MDO: 
100030776(HADHA)
SHR: 
100928252(HADHA)
OAA: 
100077524(HADHA)
GGA: 
395929(HADHA)
MGP: 
100548080(HADHA)
APLA: 
101799809(HADHA)
TGU: 
100223290(HADHA)
FAB: 
101815112(HADHA)
PHI: 
102103703(HADHA)
FPG: 
101918262(HADHA)
FCH: 
102045684(HADHA)
CLV: 
102093055(HADHA)
ASN: 
102387874(HADHA)
AMJ: 
102559143(HADHA)
PSS: 
102461507(HADHA)
CMY: 
102938765(HADHA)
ACS: 
100553746(hadha)
PBI: 
103053277(HADHA)
XLA: 
444044(hadha)
XTR: 
394832(hadha)
DRE: 
553401(hadhaa) 793834(hadhab)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350823(HADHA)
CMK: 
103183149(hadha)
BFO: 
CIN: 
SPU: 
585357(hadha)
DME: 
Dmel_CG4389(Mtpalpha)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
410325(GB16864)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_C29F3.1(ech-1) CELE_T08B2.7(T08B2.7)
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
NVE: 
HMG: 
100197152(hadha)
TAD: 
AQU: 
ATH: 
AT3G06860(MFP2) AT4G29010(AIM1)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0008s22410g POPTR_0010s01570g(POPTRDRAFT_725677) POPTR_0018s08940g(POPTRDRAFT_825852)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0348600-01(Os01g0348600) Os02t0274100-01(Os02g0274100) Os05t0155000-01(Os05g0155000) Os05t0362100-01(Os05g0362100)
OBR: 
BDI: 
SBI: 
SORBI_04g010370(SORBIDRAFT_04g010370) SORBI_09g017970(SORBIDRAFT_09g017970)
ZMA: 
100281695(pco097710) 100285945
SITA: 
PDA: 
ATR: 
s00045p00190660(AMTR_s00045p00190660) s00109p00082150(AMTR_s00109p00082150) s00109p00083880(AMTR_s00109p00083880)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
CCP: 
MBR: 
ACAN: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:7150615]
  Authors
El-Fakhri M, Middleton B.
  Title
The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.
  Journal
Biochim. Biophys. Acta. 713 (1982) 270-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
84177-52-6

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