| Entry |
|
|---|
| Name |
morphine 6-dehydrogenase;
naloxone reductase;
reductase, naloxone |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
morphine:NAD(P)+ 6-oxidoreductase |
|---|
| Reaction(IUBMB) |
morphine + NAD(P)+ = morphinone + NAD(P)H + H+ [RN:R03591 R03592] |
|---|
| Reaction(KEGG) |
R03591 R03592
 |
|---|
| Substrate |
morphine [CPD:C01516];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
morphinone [CPD:C01735];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Effector |
Mercaptoethanol [CPD:C00928] |
|---|
| Comment |
Also acts on some other alkaloids, including codeine, normorphine
and ethylmorphine, but only very slowly on 7,8-saturated derivatives
such as dihydromorphine and dihydrocodeine. In the reverse
direction, also reduces naloxone to the 6alpha-hydroxy analogue.
Activated by 2-mercaptoethanol. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway |
|---|
| Orthology |
KO: K03378 morphine 6-dehydrogenase
KO: K13374 aldo-keto reductase family 1 member C13 |
|---|
| Genes |
MMU: 27384(Akr1c13)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:2580834]
Yamano S, Kageura E, Ishida T, Toki S.
Purification and characterization of guinea pig liver morphine
6-dehydrogenase.
J. Biol. Chem. 260 (1985) 5259-64.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3539118]
Yamano S, Nishida F, Toki S.
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase.
Biochem. Pharmacol. 35 (1986) 4321-6.
Cavia porcellus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.218
IUBMB Enzyme Nomenclature: 1.1.1.218
ExPASy - ENZYME nomenclature database: 1.1.1.218
BRENDA, the Enzyme Database: 1.1.1.218
CAS: 97002-71-6 |
|---|
