| Entry |
|
|---|
| Name |
dihydrokaempferol 4-reductase;
dihydroflavanol 4-reductase;
dihydromyricetin reductase;
NADPH-dihydromyricetin reductase;
dihydroquercetin reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase |
|---|
| Reaction(IUBMB) |
cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH +
H+ [RN:R03123] |
|---|
| Reaction(KEGG) |
R03123;
(other) R03636 R04901 R05038 R06610 R07998 R07999
 |
|---|
| Substrate |
cis-3,4-leucopelargonidin [CPD:C03648];
NADP+ [CPD:C00006] |
|---|
| Product |
(+)-dihydrokaempferol [CPD:C00974];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts, in the reverse direction, on (+)-dihydroquercetin and
(+)-dihydromyricetin; each dihydroflavonol is reduced to the
corresponding cis-flavan-3,4-diol. NAD+ can act instead of NADP+,
but more slowly. Involved in the biosynthesis of anthocyanidins in
plants. |
|---|
| Pathway |
PATH: ec00941 Flavonoid biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00091 dihydroflavonol-4-reductase
KO: K13082 bifunctional dihydroflavonol 4-reductase/flavanone
4-reductase |
|---|
| Genes |
ATH: AT5G42800(DFR)
POP: POPTR_206006(DFR2) POPTR_710083(DFR1)
RCU: RCOM_1595070
VVI: 100233141(DFR)
PAU: PA14_61280
ACB: A1S_2399
MCA: MCA1017
NOC: Noc_0999
HCH: HCH_04893
AFR: AFE_2122
CVI: CV_0690(hpnA)
REU: Reut_B4897
REH: H16_B2168
RME: Rmet_4170
BMA: BMAA1958
BMV: BMASAVP1_0976
BML: BMA10229_1263
BMN: BMA10247_A2237
BPS: BPSS2165
BPM: BURPS1710b_A1280(hpnA)
BPL: BURPS1106A_A2924
BPD: BURPS668_A3049
BTE: BTH_II2241
BVI: Bcep1808_3713
BUR: Bcep18194_B0109
BCN: Bcen_5311 Bcen_5668
BCH: Bcen2424_5549 Bcen2424_6032
BAM: Bamb_5780
BXE: Bxe_B0022
NEU: NE1170(dfrA)
NMU: Nmul_A2281
GSU: GSU0687
GME: Gmet_2821
GUR: Gura_1019
PPD: Ppro_1190
BBA: Bd0142(dfrA)
RLE: RL0304
BJA: bll5833 blr6564
BRA: BRADO5042 BRADO5622
BBT: BBta_5514
MEX: Mext_1940
JAN: Jann_0529
ZMO: ZMO0867
GOX: GOX2253
ACR: Acry_0121 Acry_3396
RRU: Rru_A0058
MAG: amb1364
LLM: llmg_0992
SSA: SSA_0314(wcaG)
LSA: LSA1053
MTC: MT0147
MRA: MRA_0146
MBB: BCG_0175
MPA: MAP3556
MAV: MAV_1849 MAV_5157
MSM: MSMEG_6563
MUL: MUL_4771
MGI: Mflv_2375
MAB: MAB_0718c
MMC: Mmcs_0039
MKM: Mkms_0048
MJL: Mjls_0029
FAL: FRAAL1978
ABA: Acid345_1741
CHU: CHU_2413
SYN: slr1706(dfrA)
TEL: tlr1370
GVI: glr1747
ANA: alr4268
AVA: Ava_1218 Ava_2547
PMM: PMM1377
PMC: P9515_15511
CTE: CT1931
CCH: Cag_0240 Cag_0793
CPH: Cpha266_1339 Cpha266_1931 Cpha266_2290
PVI: Cvib_0339 Cvib_0591 Cvib_0905
PLT: Plut_0274
DEH: cbdb_A1667
DEB: DehaBAV1_1328
 |
|---|
| Structures |
PDB: 2C29 2IOD 2NNL 3BXX 3C1T |
|---|
Reference
Authors
Title
Journal
|
1
Heller, W., Forkmann, G., Britsch, L. and Grisebach, H.
Enzymatic reduction of (+)-dihydroflavonols to flavan-3,4-cis- diols
with flower extracts from Matthiola incana and its role in
anthocyanin biosynthesis.
Planta 165 (1985) 284-287. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:16664326]
Stafford HA, Lester HH.
Flavan-3-ol Biosynthesis : The Conversion of (+)-Dihydromyricetin to
Its Flavan-3,4-Diol (Leucodelphinidin) and to (+)-Gallocatechin by
Reductases Extracted from Tissue Cultures of Ginkgo biloba and
Pseudotsuga menziesii.
Plant. Physiol. 78 (1985) 791-794.
Ginkgo biloba, Pseudotsuga menziesii |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.219
IUBMB Enzyme Nomenclature: 1.1.1.219
ExPASy - ENZYME nomenclature database: 1.1.1.219
BRENDA, the Enzyme Database: 1.1.1.219
CAS: 83682-99-9 |
|---|
