| Entry |
|
|---|
| Name |
6-pyruvoyltetrahydropterin 2'-reductase;
6-pyruvoyltetrahydropterin reductase;
6PPH4(2'-oxo) reductase;
6-pyruvoyl tetrahydropterin (2'-oxo)reductase;
6-pyruvoyl-tetrahydropterin 2'-reductase;
pyruvoyl-tetrahydropterin reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase |
|---|
| Reaction(IUBMB) |
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ =
6-pyruvoyltetrahydropterin + NADPH + H+ [RN:R04285] |
|---|
| Reaction(KEGG) |
R04285
 |
|---|
| Substrate |
6-lactoyl-5,6,7,8-tetrahydropterin [CPD:C04244];
NADP+ [CPD:C00006] |
|---|
| Product |
6-pyruvoyltetrahydropterin [CPD:C03684];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Not identical with EC 1.1.1.153 sepiapterin reductase. |
|---|
| Pathway |
PATH: ec00790 Folate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04071 6-pyruvoyltetrahydropterin 2'-reductase |
|---|
| Genes |
HPY: HP0934
HPA: HPAG1_0914
CJE: Cj0160c
CJR: CJE0156
CJJ: CJJ81176_0196
CFF: CFF8240_0222
CCV: CCV52592_0823
CHA: CHAB381_0327
PTO: PTO1063
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4004850]
Milstien S, Kaufman S.
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin
triphosphate to tetrahydropterin intermediates.
Biochem. Biophys. Res. Commun. 128 (1985) 1099-107.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.220
IUBMB Enzyme Nomenclature: 1.1.1.220
ExPASy - ENZYME nomenclature database: 1.1.1.220
BRENDA, the Enzyme Database: 1.1.1.220
CAS: 97089-79-7 |
|---|
