| Entry |
|
|---|
| Name |
(R)-4-hydroxyphenyllactate dehydrogenase;
(R)-aromatic lactate dehydrogenase;
D-hydrogenase, D-aryllactate |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase |
|---|
| Reaction(IUBMB) |
(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ =
3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+ [RN:R03337 R03339] |
|---|
| Reaction(KEGG) |
R03337 R03339;
(other) R01370 R01371 R03336 R03338
 |
|---|
| Substrate |
(R)-3-(4-hydroxyphenyl)lactate [CPD:C03964];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006] |
|---|
| Product |
3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts, more slowly, on (R)-3-phenyllactate,
(R)-3-(indol-3-yl)lactate and (R)-lactate. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid |
|---|
Reference
Authors
Title
Journal
|
1
Bode, R., Lippoldt, A. and Birnbaum, D.
Purification and properties of D-aromatic lactate dehydrogenase an
enzyme involved in the catabolism of the aromatic amino acids of
Candida maltosa.
Biochem. Physiol. Pflanzen 181 (1986) 189-198. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.222
IUBMB Enzyme Nomenclature: 1.1.1.222
ExPASy - ENZYME nomenclature database: 1.1.1.222
BRENDA, the Enzyme Database: 1.1.1.222
CAS: 101754-02-3 |
|---|
