KEGG   ENZYME: 1.1.1.225Help
Entry
EC 1.1.1.225                Enzyme                                 

Name
chlordecone reductase;
CDR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
chlordecone-alcohol:NADP+ 2-oxidoreductase
Reaction(IUBMB)
chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]
Reaction(KEGG)
Substrate
chlordecone alcohol [CPD:C02817];
NADP+ [CPD:C00006]
Product
chlordecone [CPD:C01792];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Chlordecone is an organochlorine pesticide.
History
EC 1.1.1.225 created 1989
Orthology
K00092  
chlordecone reductase
Genes
HSA: 
1109(AKR1C4)
PTR: 
450274(AKR1C4)
Taxonomy
Reference
1  [PMID:2427522]
  Authors
Molowa DT, Shayne AG, Guzelian PS.
  Title
Purification and characterization of chlordecone reductase from human liver.
  Journal
J. Biol. Chem. 261 (1986) 12624-7.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
102484-73-1

KEGG   ENZYME: 1.1.1.50Help
Entry
EC 1.1.1.50                 Enzyme                                 

Name
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
History
EC 1.1.1.50 created 1961, modified 1986, modified 1990, modified 2012, modified 2013
Pathway
Primary bile acid biosynthesis
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K00037  
3-alpha-hydroxysteroid dehydrogenase
Genes
HSA: 
1109(AKR1C4)
PTR: 
450274(AKR1C4)
Taxonomy
Reference
1  [PMID:14406805]
  Authors
JARABAK J, TALALAY P.
  Title
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 235 (1960) 2147-51.
  Organism
Pseudomonas testosteroni
Reference
2  [PMID:13405910]
  Authors
KOCHAKIAN CD, CARROLL BR, UHRI B.
  Title
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates.
  Journal
J. Biol. Chem. 224 (1957) 811-8.
  Organism
Cavia porcellus
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 218 (1956) 661-74.
  Organism
Pseudomonas testosteroni
Reference
4  [PMID:3479982]
  Authors
Penning TM, Sharp RB.
  Title
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem. Biophys. Res. Commun. 148 (1987) 646-52.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-56-2

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