| Entry |
|
|---|
| Name |
hydroxyphenylpyruvate reductase;
HPRP |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
4-hydroxyphenyllactate:NAD+ oxidoreductase |
|---|
| Reaction(IUBMB) |
3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate +
NADH + H+ [RN:R03336] |
|---|
| Reaction(KEGG) |
R03336;
(other) R01370 R01371 R03338 R03373
 |
|---|
| Substrate |
3-(4-hydroxyphenyl)lactate [CPD:C03672];
NAD+ [CPD:C00003] |
|---|
| Product |
3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Also acts on 3-(3,4-dihydroxyphenyl)lactate. Involved with EC
2.3.1.140 rosmarinate synthase in the biosynthesis of rosmarinic
acid. |
|---|
| Pathway |
PATH: ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid |
|---|
| Structures |
PDB: 3BA1 3BAZ |
|---|
Reference
Authors
Title
Journal
|
1
Petersen, M. and Alfermann, A.W.
Two new enzymes of rosmarinic acid biosynthesis from cell cultures
of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic
acid synthase.
Z. Naturforsch. C: Biosci. 43 (1988) 501-504. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.237
IUBMB Enzyme Nomenclature: 1.1.1.237
ExPASy - ENZYME nomenclature database: 1.1.1.237
BRENDA, the Enzyme Database: 1.1.1.237
CAS: 117590-77-9 |
|---|
