KEGG   ENZYME: 1.1.1.237Help
Entry
EC 1.1.1.237                Enzyme                                 

Name
hydroxyphenylpyruvate reductase;
HPRP
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-hydroxyphenyllactate:NAD+ oxidoreductase
Reaction(IUBMB)
3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH + H+ [RN:R03336]
Reaction(KEGG)
Substrate
3-(4-hydroxyphenyl)lactate [CPD:C03672];
NAD+ [CPD:C00003]
Product
3-(4-hydroxyphenyl)pyruvate [CPD:C01179];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on 3-(3,4-dihydroxyphenyl)lactate. Involved with EC 2.3.1.140 rosmarinate synthase in the biosynthesis of rosmarinic acid.
History
EC 1.1.1.237 created 1992
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Tyrosine metabolism
Phenylalanine metabolism
Tropane, piperidine and pyridine alkaloid biosynthesis
Biosynthesis of secondary metabolites
Reference
1
  Authors
Petersen, M. and Alfermann, A.W.
  Title
Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase.
  Journal
Z. Naturforsch. C: Biosci. 43 (1988) 501-504.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
117590-77-9

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