KEGG   ENZYME: 1.1.1.239Help
Entry
EC 1.1.1.239                Enzyme                                 
Name
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+);
3alpha,17beta-hydroxy steroid dehydrogenase;
3alpha(17beta)-HSD;
17-ketoreductase (ambiguous);
17beta-HSD (ambiguous);
HSD17B6 (gene name);
HSD17B8 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD+ = androstenedione + NADH + H+ [RN:R01836]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on other 17beta-hydroxysteroids and on the 3alpha-hydroxy group of pregnanes and bile acids. Different from EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (B-specific) or EC 1.1.1.213 3alpha-hydroxysteroid dehydrogenase (A-specific).
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K13368  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13369  
17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13370  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Genes
HSA: 
3294(HSD17B2) 7923(HSD17B8) 8630(HSD17B6)
PTR: 
454269(HSD17B2) 746685(HSD17B8)
PPS: 
100983435(HSD17B2) 100993294(HSD17B8) 100996145(HSD17B6)
GGO: 
101131453(HSD17B2) 101143846(HSD17B8) 101153072(HSD17B6)
PON: 
100456547(HSD17B2) 100458219(HSD17B6) 100461538(HSD17B8)
MCC: 
713549(HSD17B6) 714282 718119(HSD17B8)
MMU: 
14979(H2-Ke6) 15486(Hsd17b2) 27400(Hsd17b6)
RNO: 
100362350 286964(Hsd17b6) 361802(Hsd17b8) 79243(Hsd17b2)
CFA: 
481118(HSD17B6) 489690(HSD17B2) 607895(HSD17B8)
AML: 
FCA: 
101085592(HSD17B2) 101086309(HSD17B8) 101088341(HSD17B6)
BTA: 
515710(HSD17B2) 532422(HSD17B8) 533086(HSD17B6)
SSC: 
100154372(HSD17B8) 100312973(HSD17B2) 100620470
ECB: 
100052840 100061414 100146214
MDO: 
100025234 100031815
SHR: 
100914913 100921563(HSD17B2) 100931687
OAA: 
100076931
GGA: 
415807(HSD17B2)
MGP: 
100549838
TGU: 
100228039(HSD17B2) 100231423
ACS: 
100564174
XLA: 
398882(rdh16)
XTR: 
100135184(rdh16) 100497002 549425(hsd17b8)
DRE: 
449537(hsd17b2) 64815(hsd17b8)
TRU: 
101066298
OLA: 
101165741
BFO: 
BRAFLDRAFT_281754 BRAFLDRAFT_291019
CIN: 
100184861
SPU: 
755047
PHU: 
Phum_PHUM105710
ISC: 
IscW_ISCW001832 IscW_ISCW007527
CBR: 
CBG18334(Cbr-dhs-11)
NVE: 
NEMVE_v1g241360
 » show all
Taxonomy
Reference
1  [PMID:15436478]
  Authors
SWEAT ML, SAMUELS LT, LUMRY R.
  Title
Preparation and characterization of the enzyme which converts testosterone to androstenedione.
  Journal
J. Biol. Chem. 185 (1950) 75-84.
Reference
2  [PMID:13781425]
  Authors
VILLEE CA, SPENCER JM.
  Title
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 3615-9.
Reference
3  [PMID:13696735]
  Authors
ENDAHL GL, KOCHAKIAN CD, HAMM D.
  Title
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 2792-6.
Reference
4  [PMID:2317205]
  Authors
Ohmura M, Hara A, Nakagawa M, Sawada H.
  Title
Demonstration of 3 alpha(17 beta)-hydroxysteroid dehydrogenase distinct from 3 alpha-hydroxysteroid dehydrogenase in hamster liver.
  Journal
Biochem. J. 266 (1990) 583-9.
  Organism
Mesocricetus auratus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
126469-82-7
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