| Entry |
|
|---|
| Name |
codeinone reductase (NADPH) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
codeine:NADP+ oxidoreductase |
|---|
| Reaction(IUBMB) |
codeine + NADP+ = codeinone + NADPH + H+ [RN:R05124] |
|---|
| Reaction(KEGG) |
R05124
 |
|---|
| Substrate |
codeine [CPD:C06174];
NADP+ [CPD:C00006] |
|---|
| Product |
codeinone [CPD:C06171];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Catalyses the reversible reduction of codeinone to codeine, which is
a direct precursor of morphine in the opium poppy plant, Papaver
somniferum. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13394 codeinone reductase |
|---|
Reference
Authors
Title
Journal
|
1
Lenz, R. and Zenk, M.H.
Stereoselective reduction of codeinone, the penultimate step during
morphine biosynthesis in Papaver somniferum.
Tetrahedron Lett. 36 (1995) 2449-2452. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7588736]
Lenz R, Zenk MH.
Purification and properties of codeinone reductase (NADPH) from
Papaver somniferum cell cultures and differentiated plants.
Eur. J. Biochem. 233 (1995) 132-9.
Papaver somniferum |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.247
IUBMB Enzyme Nomenclature: 1.1.1.247
ExPASy - ENZYME nomenclature database: 1.1.1.247
BRENDA, the Enzyme Database: 1.1.1.247
CAS: 153302-41-1 |
|---|
