| Entry |
|
|---|
| Name |
salutaridine reductase (NADPH) |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
salutaridinol:NADP+ 7-oxidoreductase |
|---|
| Reaction(IUBMB) |
salutaridinol + NADP+ = salutaridine + NADPH + H+ [RN:R04697] |
|---|
| Reaction(KEGG) |
R04697
 |
|---|
| Substrate |
salutaridinol [CPD:C05220];
NADP+ [CPD:C00006] |
|---|
| Product |
salutaridine [CPD:C05179];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Catalyses the reversible reduction of salutaridine to salutaridinol,
which is a direct precursor of morphinan alkaloids in the poppy
plant. |
|---|
| Pathway |
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K13392 salutaridine reductase (NADPH) |
|---|
Reference
Authors
Title
Journal
|
1
Gerady, R. and Zenk, M.H.
Purification and characterization of salutaridine:NADPH
7-oxidoreductase from Papaver somniferum.
Phytochemistry 34 (1993) 125-132. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.248
IUBMB Enzyme Nomenclature: 1.1.1.248
ExPASy - ENZYME nomenclature database: 1.1.1.248
BRENDA, the Enzyme Database: 1.1.1.248
CAS: 152743-95-8 |
|---|
