KEGG   ENZYME: 1.1.1.252Help
Entry
EC 1.1.1.252                Enzyme                                 

Name
tetrahydroxynaphthalene reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
scytalone:NADP+ Delta5-oxidoreductase
Reaction(IUBMB)
scytalone + NADP+ = 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+ [RN:R02906]
Reaction(KEGG)
R02906;
(other) R03322
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Substrate
scytalone [CPD:C00779];
NADP+ [CPD:C00006]
Product
1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. Involved with EC 4.2.1.94 scytalone dehydratase in the biosynthesis of melanin in pathogenic fungi.
History
EC 1.1.1.252 created 1992 as EC 1.3.1.50, transferred 1999 to EC 1.1.1.252
Orthology
K17739  
tetrahydroxynaphthalene reductase
Genes
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AOR: 
AOR_1_40014(AO090026000019)
AFV: 
NFI: 
PNO: 
PTE: 
BZE: 
ZTR: 
PFJ: 
BCOM: 
 » show all
Taxonomy
Reference
1
  Authors
Wheeler, M.H. and Greenblatt, G.A.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp. Mycol. 12 (1988) 151-160.
Reference
2  [PMID:8112349]
  Authors
Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M.
  Title
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing.
  Journal
Eur. J. Biochem. 219 (1994) 985-92.
  Organism
Magnaporthe grisea
  Sequence
[mgr:MGG_02252]
Reference
3  [PMID:9048570]
  Authors
Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB.
  Title
Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism.
  Journal
Biochemistry. 36 (1997) 1852-60.
  Organism
Magnaporthe grisea
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
141350-13-2

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