| Entry |
|
|---|
| Name |
dTDP-4-dehydro-6-deoxyglucose reductase;
dTDP-4-keto-6-deoxyglucose reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
dTDP-D-fucose:NADP+ oxidoreductase |
|---|
| Reaction(IUBMB) |
dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH +
H+ [RN:R05687] |
|---|
| Reaction(KEGG) |
R05687
 |
|---|
| Substrate |
dTDP-D-fucose [CPD:C07277];
NADP+ [CPD:C00006] |
|---|
| Product |
dTDP-4-dehydro-6-deoxy-D-glucose [CPD:C11907];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
The enzyme from the Gram-negative bacterium Actinobacillus
actinomycetemcomitans forms activated fucose for incorporation into
capsular polysaccharide. |
|---|
| Pathway |
PATH: ec00523 Polyketide sugar unit biosynthesis |
|---|
| Orthology |
KO: K13306 dTDP-4-dehydro-6-deoxyglucose reductase |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:10358040]
Yoshida Y, Nakano Y, Nezu T, Yamashita Y, Koga T.
A novel NDP-6-deoxyhexosyl-4-ulose reductase in the pathway for the
synthesis of thymidine diphosphate-D-fucose.
J. Biol. Chem. 274 (1999) 16933-9.
Actinobacillus actinomycetemcomitans |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.266
IUBMB Enzyme Nomenclature: 1.1.1.266
ExPASy - ENZYME nomenclature database: 1.1.1.266
BRENDA, the Enzyme Database: 1.1.1.266 |
|---|
