| Entry |
|
|---|
| Name |
GDP-L-fucose synthase;
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) |
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| Reaction(IUBMB) |
GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
[RN:R05692] |
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| Reaction(KEGG) |
R05692;
(other) R07059 R07060
 |
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| Substrate |
GDP-L-fucose [CPD:C00325];
NADP+ [CPD:C00006] |
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| Product |
GDP-4-dehydro-6-deoxy-D-mannose [CPD:C01222];
NADPH [CPD:C00005];
H+ [CPD:C00080] |
|---|
| Comment |
Both human and Escherichia coli enzymes can use NADH in place of
NADPH to a slight extent. |
|---|
| Pathway |
PATH: ec00051 Fructose and mannose metabolism
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K02377 GDP-L-fucose synthase |
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| Genes |
HSA: 7264(TSTA3)
PTR: 464445(TSTA3)
MCC: 698005(TSTA3)
MMU: 22122(Tsta3)
RNO: 300036(Tsta3)
CFA: 475116(TSTA3)
BTA: 513158(TSTA3)
ECB: 100063484
OAA: 100089427
GGA: 420292(TSTA3)
XTR: 394680(tsta3)
DRE: 494077(tsta3)
BFO: BRAFLDRAFT_231666
CIN: 100180068 100181509
SPU: 585407
DME: Dmel_CG3495(Gmer)
DPO: Dpse_GA17480
DAN: Dana_GF11320
DER: Dere_GG20086
DPE: Dper_GL10196
DSE: Dsec_GM15602
DSI: Dsim_GD25098
DYA: Dyak_GE11625
DGR: Dgri_GH20607
DMO: Dmoj_GI19163
AGA: AgaP_AGAP008092
AAG: AaeL_AAEL008593 AaeL_AAEL014651
CQU: CpipJ_CPIJ001725
AME: 552755
NVI: 100116222
TCA: 655452
API: 100166652(Acypi007507)
ISC: IscW_ISCW024796
CEL: R01H2.5(ger-1)
CBR: CBG16511
SMM: Smp_104720
NVE: NEMVE_v1g124032
HMG: 100197574
TAD: TRIADDRAFT_14880
ATH: AT1G17890(GER2) AT1G73250(GER1)
POP: POPTR_737925
RCU: RCOM_1282230
VVI: 100267310
OSA: 4341699(Os06g0652400)
SBI: SORBI_10g025890(SORBIDRAFT_10g025890)
ZMA: 100283867
PPP: PHYPADRAFT_197412
LBC: LACBIDRAFT_317289
MBR: MONBRDRAFT_34882
DDI: DDBDRAFT_0190865
PFA: PF10_0137
PFH: PFHG_03884
PBE: PB001564.02.0
PKN: PKH_081350
PVX: PVX_094915
TBR: Tb11.01.5560
TCR: 511727.300
PTI: PHATRDRAFT_15125
TPS: THAPSDRAFT_26470(GFS1)
ECO: b2052(fcl)
ECJ: JW2037(fcl)
ECD: ECDH10B_2202(fcl)
EBW: BWG_1842(fcl)
ECE: Z3197(fci) Z3216(wcaG)
ECS: ECs2838 ECs2857
ECF: ECH74115_2967 ECH74115_2987(fcl)
ETW: ECSP_2788 ECSP_2807
ECG: E2348C_2179
ECC: c2578(wcaG)
ECI: UTI89_C2326(wcaG)
ECP: ECP_2092
ECV: APECO1_1142(wcaG)
ECW: EcE24377A_2345(fcl)
ECM: EcSMS35_1010(fcl)
ECY: ECSE_2326
ECL: EcolC_1589
ECK: EC55989_2308(fcl)
ECQ: ECED1_2398(fcl)
ECR: ECIAI1_2127(fcl)
ECT: ECIAI39_0963(fcl)
ECZ: ECS88_2149(fcl)
EUM: ECUMN_2388(fcl)
ELF: LF82_0626(fcl)
EBL: B21_01947(fcl)
EBD: ECBD_1603
EBR: ECB_01958(wcaG)
EOH: ECO103_2531(fcl)
EOI: ECO111_2761(wbdJ)
EOJ: ECO26_2963(fcl)
EFE: EFER_2136(fcl)
STY: STY2320(fcl)
STT: t0765(fcl)
SPT: SPA0758(fcl)
SEK: SSPA0715
SPQ: SPAB_00922
SEI: SPC_1613(fcl)
SEC: SC2109(wcaG)
SEH: SeHA_C2334(fcl)
SEE: SNSL254_A2290(fcl)
SEW: SeSA_A2341(fcl)
SEA: SeAg_B2233(fcl)
SED: SeD_A2448(fcl)
SEG: SG2140(wcaG)
SET: SEN2104(wcaG)
SES: SARI_00790
STM: STM2108(wcaG)
YPK: y1080(wcaG)
YPM: YP_0826(wcaG2)
YPA: YPA_2595
YPN: YPN_0987
YPG: YpAngola_A1253(fcl)
YPP: YPDSF_2739
YPS: YPTB1010(fcl)
YPI: YpsIP31758_3040(fcl)
YPY: YPK_3182
YEN: YE3074(fcl)
SFL: SF2115(wcaG)
SFX: S2238(wcaG)
SFV: SFV_2109(wcaG)
SSN: SSON_2105(wcaG)
SBO: SBO_0879(wcaG)
SBC: SbBS512_E1180(fcl)
PCT: PC1_1313
SGL: SG0330
ENT: Ent638_2666
ESA: ESA_01166
CTU: Ctu_27490(fcl)
KPU: KP1_3709(wcaG)
CKO: CKO_00733
VVY: VV0350
PFS: PFLU3667
CPS: CPS_4200
PIN: Ping_0771
CBU: CBU_0688(wcaG)
CBS: COXBURSA331_A0806(wcaG)
CBD: CBUD_0702(wcaG)
CBG: CbuG_1314(wcaG)
CBC: CbuK_1566(wcaG)
MCA: MCA1147(fcl)
FPH: Fphi_1249
NOC: Noc_1234
TGR: Tgr7_2092
TAU: Tola_2052
RMA: Rmag_0902
RME: Rmet_5859
CTI: RALTA_B0040(fcl)
BVI: Bcep1808_6522
BAM: Bamb_0747
BXE: Bxe_A3862 Bxe_C1084
BPH: Bphy_2470
BPY: Bphyt_0822
PNU: Pnuc_0303
RFR: Rfer_1235
POL: Bpro_4000
PNA: Pnap_3191
VAP: Vapar_3192
MPT: Mpe_A2730
LCH: Lcho_0624 Lcho_2350
AZO: azo3586(fcl1) azo3599(fcl2)
TBD: Tbd_1775
MMB: Mmol_1026
HPY: HP0045
HPJ: jhp0039
HPA: HPAG1_0042
HPS: HPSH_00220
HPG: HPG27_40(nolK)
HPP: HPP12_0040
HPB: HELPY_0041(fcl)
HHE: HH0173
HAC: Hac_0057(wbcJ)
CJE: Cj1428c(fcl)
CJR: CJE1612(fcl)
CJJ: CJJ81176_1427(fcl)
CJD: JJD26997_0706 JJD26997_1764 JJD26997_1765
SDL: Sdel_1789
SUN: SUN_2143
NAM: NAMH_1667
GSU: GSU0627
GME: Gmet_1312
GUR: Gura_3209
GLO: Glov_0785 Glov_2751
GBM: Gbem_0865 Gbem_1135
GEO: Geob_2123
GEM: GM21_3150
PPD: Ppro_1425
DVU: DVU0090(wcaG)
DVL: Dvul_2872
DVM: DvMF_2695
DDE: Dde_0425 Dde_2900
DDS: Ddes_0411
DMA: DMR_38920(fcl)
LIP: LIC080
DBA: Dbac_2560 Dbac_3270
DPS: DP0023
DOL: Dole_1282
ACP: A2cp1_4447
AFW: Anae109_4440
ANK: AnaeK_4423
SAT: SYN_00585
PUB: SAR11_0571(wcaG)
MLO: mlr8749
ATU: Atu4790(fcl)
ATC: AGR_L_185
RET: RHE_CH00763(nolK)
REC: RHECIAT_CH0000850
RLE: RL0826(fcl) pRL90132(fcl)
RLT: Rleg2_0426 Rleg2_6434
RLG: Rleg_0438 Rleg_6238
RHI: NGR_a00420(nolK)
BME: BMEII0849 BMEII0850
BMC: BAbS19_II07420
BMS: BRA0418
BMT: BSUIS_B0421
BCS: BCAN_B0421
BMR: BMI_II415
OAN: Oant_3371
BJA: bll1630(nolK) bll5464(fcl)
BRA: BRADO2184(fcl) BRADO5259(fcl)
BBT: BBta_5711(fcl)
RPB: RPB_1526 RPB_1528
NWI: Nwi_2384
AZC: AZC_3850
MEX: Mext_4620
MEA: Mex_1p5071(fcl)
MDI: METDI5672(fcl)
MRD: Mrad2831_2845
MPO: Mpop_5160
MCH: Mchl_5085
MNO: Mnod_6328
MSL: Msil_0081
CCS: CCNA_00471
CAK: Caul_4918
SIT: TM1040_1481
RSP: RSP_4108(wcaG)
PDE: Pden_1297
DSH: Dshi_4142
HBA: Hbal_1798
ELI: ELI_13460
RRU: Rru_A0254
RCE: RC1_4030(fcl)
MAG: amb0161
MGM: Mmc1_3315
GWC: GWCH70_1668
GYM: GYMC10_5339
BBE: BBR47_17520(fcl)
PJD: Pjdr2_0403
CAC: CAC2179
CCE: Ccel_3442
SWO: Swol_0619
DRM: Dred_1395
DAE: Dtox_2842
HMO: HM1_1141
MTU: Rv1512(epiA)
MTC: MT1562(wcaG)
MRA: MRA_1524(epiA)
MTF: TBFG_11546
MTB: TBMG_02464(TBMG_02464.1)
MPA: MAP1232(epiA)
RHA: RHA1_ro05445
RER: RER_13250(fcl)
SGR: SGR_1541
CMI: CMM_1599(fclA)
CMS: CMS_1580(fcl)
AAU: AAur_4112
KRH: KRH_20470(fcl)
ACE: Acel_0450
KRA: Krad_1828
AMI: Amir_4843
LIL: LA1577
LIC: LIC12205(fcl)
LBJ: LBJ_1111
LBL: LBL_1165
LBI: LEPBI_I2038(fcl)
LBF: LBF_1985
BHY: BHWA1_00144(wcaG)
ABA: Acid345_3813
BTH: BT_1225
BFR: BF1822
BFS: BF1887(fcl)
BVU: BVU_2651 BVU_3945
PGI: PG1289(fcl)
PGN: PGN_1079
PDI: BDI_0651 BDI_2202
CHU: CHU_0060(wcaG)
DFE: Dfer_3785
CPI: Cpin_1091 Cpin_2362
PHE: Phep_4219
GFO: GFO_0556(wcaG)
FJO: Fjoh_0329
RBI: RB2501_01151 RB2501_06710
OTE: Oter_4242
AMU: Amuc_1248
RBA: RB2521
TAI: Taci_0018
SYN: sll1213
SYW: SYNW0423
SYC: syc2390_d(wcaG)
SYF: Synpcc7942_1700
SYG: sync_0145(wcaG-2)
SYR: SynRCC307_0218(wcaG)
SYX: SynWH7803_0113(wcaG)
SYP: SYNPCC7002_A2832
CYA: CYA_1879
CYB: CYB_1556
TEL: tll0633
MAR: MAE_29900
CYT: cce_0044 cce_3232
CYP: PCC8801_2320 PCC8801_2562
CYC: PCC7424_3396
CYN: Cyan7425_0212
CYH: Cyan8802_2371 Cyan8802_3544
GVI: glr3792
ANA: all4826
NPU: Npun_F3486
AVA: Ava_2096
PMA: Pro0064(wcaG)
PMM: PMM1207
PMI: PMT9312_1315
PMB: A9601_14001
PMC: P9515_13691 P9515_14001
PMG: P9301_14451
PMH: P9215_14311(wcaG)
TER: Tery_0491
AMR: AM1_3968
CCH: Cag_0651
CPH: Cpha266_2610
CPB: Cphamn1_1931
PVI: Cvib_0614
PLT: Plut_1864
PPH: Ppha_0570
CTS: Ctha_2066
CAU: Caur_2121
CAG: Cagg_1542
CHL: Chy400_2286
DGE: Dgeo_2648
SUL: SYO3AOP1_1406
SAF: SULAZ_1203
TYE: THEYE_A0471
MMZ: MmarC7_0339
MBA: Mbar_A0035
MMA: MM_0658
MPL: Mpal_2127
MPD: MCP_2714
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:3338988]
Chang S, Duerr B, Serif G.
An epimerase-reductase in L-fucose synthesis.
J. Biol. Chem. 263 (1988) 1693-7.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:11030750]
Mattila P, Rabina J, Hortling S, Helin J, Renkonen R.
Functional expression of Escherichia coli enzymes synthesizing
GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces
cerevisiae.
Glycobiology. 10 (2000) 1041-7.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10480878]
Menon S, Stahl M, Kumar R, Xu GY, Sullivan F.
Stereochemical course and steady state mechanism of the reaction
catalyzed by the GDP-fucose synthetase from Escherichia coli.
J. Biol. Chem. 274 (1999) 26743-50.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:9862812]
Somers WS, Stahl ML, Sullivan FX.
GDP-fucose synthetase from Escherichia coli: structure of a unique
member of the short-chain dehydrogenase/reductase family that
catalyzes two distinct reactions at the same active site.
Structure. 6 (1998) 1601-12.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.271
IUBMB Enzyme Nomenclature: 1.1.1.271
ExPASy - ENZYME nomenclature database: 1.1.1.271
BRENDA, the Enzyme Database: 1.1.1.271
CAS: 113756-18-6 |
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