KEGG   ENZYME: 1.1.1.28Help
Entry
EC 1.1.1.28                 Enzyme                                 
Name D-lactate dehydrogenase;
lactic acid dehydrogenase;
lactic acid dehydrogenase;
D-specific lactic dehydrogenase;
D-(-)-lactate dehydrogenase (NAD+);
D-lactic acid dehydrogenase;
D-lactic dehydrogenase
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname (R)-lactate:NAD+ oxidoreductase
Reaction(IUBMB) (R)-lactate + NAD+ = pyruvate + NADH + H+ [RN:R00704]
Reaction(KEGG) R00704
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Substrate (R)-lactate [CPD:C00256];
NAD+ [CPD:C00003]
Product pyruvate [CPD:C00022];
NADH [CPD:C00004];
H+ [CPD:C00080]
Pathway PATH: ec00620  Pyruvate metabolism
Orthology KO: K03777  D-lactate dehydrogenase
KO: K03778  D-lactate dehydrogenase
Genes NCR: NCU00780
MGR: MGG_08725
FGR: FG09696.1
ANI: AN0628.2
AFM: AFUA_1G17040
AOR: AO090023000577
ANG: An01g09780
AFV: AFLA_109930
PCS: Pc21g23650
NFI: NFIA_008330
CNE: CNA08110
CNB: CNBA7930
TET: TTHERM_01014570
PTM: GSPATT00008304001
ECO: b1380(ldhA) b2133(dld)
ECJ: JW1375(ldhA) JW2121(dld)
ECD: ECDH10B_1505(ldhA) ECDH10B_2289(dld)
EBW: BWG_1209(ldhA) BWG_1917(dld)
ECE: Z2329(ldhA) Z3382(dld)
ECS: ECs2002 ECs3020
ECF: ECH74115_2002(idhA) ECH74115_3259(dld)
ETW: ECSP_1878(ldhA) ECSP_3005(dld)
ECG: E2348C_1542(ldhA) E2348C_2280(dld)
ECC: c1827(ldhA) c2664(dld)
ECI: UTI89_C1623(ldhA) UTI89_C2407(dld)
ECP: ECP_1406 ECP_2172
ECV: APECO1_4416(dld) APECO1_554(ldhA)
ECW: EcE24377A_1565(idhA) EcE24377A_2423(dld)
ECX: EcHS_A1467(idhA) EcHS_A2268(dld)
ECM: EcSMS35_0911(dld) EcSMS35_1771(idhA)
ECY: ECSE_1465 ECSE_2401
ECL: EcolC_1514 EcolC_2275
ECK: EC55989_1516(ldhA) EC55989_2383(dld)
ECQ: ECED1_1564(ldhA) ECED1_2577(dld)
ECR: ECIAI1_1380(ldhA) ECIAI1_2211(dld)
ECT: ECIAI39_0863(dld) ECIAI39_1705(ldhA)
ECZ: ECS88_1496(ldhA) ECS88_2277(dld)
EUM: ECUMN_1647(ldhA) ECUMN_2467(dld)
ELF: LF82_0496(dld) LF82_1173(ldhA)
EBL: B21_01364(ldhA) B21_02021(dld)
EBD: ECBD_1525 ECBD_2243
EBR: ECB_01352(ldhA) ECB_02063(dld)
EOH: ECO103_1516(ldhA) ECO103_2609(dld)
EOI: ECO111_1773(ldhA) ECO111_2851(dld)
EOJ: ECO26_1984(ldhA) ECO26_3046(dld)
EFE: EFER_1618(ldhA) EFER_2220(dld)
STY: STY1422(ldhA) STY2397(dld)
STT: t0688(dld) t1550(ldhA)
SPT: SPA0684(dld) SPA1239(ldhA)
SEK: SSPA0643 SSPA1148
SPQ: SPAB_00852 SPAB_01625
SEI: SPC_1536(dld) SPC_2088(ldhA)
SEC: SC1642(ldhA) SC2183(dld)
SEH: SeHA_C1827 SeHA_C2401
SEE: SNSL254_A1764 SNSL254_A2356
SEW: SeSA_A1767 SeSA_A2405
SEA: SeAg_B1509 SeAg_B2312
SED: SeD_A1692 SeD_A2513
SEG: SG1472(ldhA) SG2203(dld)
SET: SEN1405(ldhA) SEN2161(dld)
SES: SARI_00732 SARI_01337
STM: STM1647(ldhA) STM2167(dld)
YPE: YPO1177(dld) YPO2329(hslI)
YPK: y2004(ldhA) y3012(dld)
YPM: YP_0960(dld) YP_2115(ldhA1)
YPA: YPA_0888 YPA_1678
YPN: YPN_1788 YPN_2800
YPG: YpAngola_A1351(dld) YpAngola_A2212(ldhA)
YPP: YPDSF_0817 YPDSF_2519
YPS: YPTB1218(dld) YPTB2248(ldhA)
YPI: YpsIP31758_1808(ldhA) YpsIP31758_2805(dld)
YPY: YPK_1918 YPK_2884
YPB: YPTS_1306 YPTS_2324
YEN: YE2098(hslI) YE2883(dld)
SFL: SF1814(ldhA) SF2218(dld)
SFX: S1459(ldhA) S2347(dld)
SFV: SFV_1805(ldhA) SFV_2209(dld)
SSN: SSON_1744(ldhA) SSON_2190(dld)
SBO: SBO_1011(dld) SBO_1686(ldhA)
SBC: SbBS512_E0839(dld) SbBS512_E1618(idhA)
SDY: SDY_1464(ldhA) SDY_2155(dld)
ECA: ECA2000(ldhA) ECA3181(dld)
PCT: PC1_2294
PWA: Pecwa_1315 Pecwa_2594
ETA: ETA_16590(ldhA) ETA_22430(dld)
PLU: plu2145(ldhA) plu2848(dld)
PAY: PAU_01690(dld) PAU_02421(ldhA)
ENT: Ent638_1942 Ent638_2732
ESA: ESA_01106 ESA_01687
CTU: Ctu_22700(ldhA) Ctu_28020(dld)
KPN: KPN_01449(ldhA) KPN_02569(dld)
KPE: KPK_1598(dld) KPK_3023(ldhA)
KPU: KP1_2458(ldhA) KP1_3796(dld)
CKO: CKO_00661 CKO_01429
SPE: Spro_1364 Spro_2600
PMR: PMI0847(dld) PMI1181(ldhA)
EIC: NT01EI_1147 NT01EI_1938
ETR: ETAE_1048(dld) ETAE_1771(ldhA)
HDE: HDEF_1992(ldhA)
DDA: Dd703_1743
DDC: Dd586_1740
DZE: Dd1591_1778
HIN: HI0085(ldhA) HI1649(dld)
HIT: NTHI0099(ddh) NTHI1952(dld)
HIP: CGSHiEE_03810
HIQ: CGSHiGG_01925 CGSHiGG_02970(cysS)
HAP: HAPS_1875(dld) HAPS_2117(ldhA)
HSO: HS_0784(dld)
HSM: HSM_1251
MSU: MS2079(ldhA)
APL: APL_0687(dld)
APJ: APJL_0685(dld)
APA: APP7_0729
ASU: Asuc_0005
AAP: NT05HA_1399
AAT: D11S_1899
XFA: XF0347
XFT: PD1708
XFM: Xfasm12_1878
XFN: XfasM23_1801
XCC: XCC0708(dld)
XCB: XC_3526
XCA: xccb100_3647(dld)
XCV: XCV0814
XAC: XAC0762(dld)
XOO: XOO3841(dld)
XOM: XOO_3619
XOP: PXO_04382
SML: Smlt0738(glcD) Smlt1351(ldhA) Smlt2907(dld)
SMT: Smal_0587 Smal_1136 Smal_2359
VCH: VCA0192
VCO: VC0395_1085(ldhA)
VCM: VCM66_A0188(ldhA)
VCJ: VCD_000057
VVU: VV1_2200
VVY: VV2174
VPA: VPA0144 VPA1005
VHA: VIBHAR_05675 VIBHAR_06767
VSP: VS_II0150
VEX: VEA_000051 VEA_000855
VFI: VF_1055(ldhA)
VFM: VFMJ11_1128
PPR: PBPRA1210 PBPRA2224
PAE: PA0927(ldhA)
PAU: PA14_52270(ldhA)
PAP: PSPA7_4583(ldhA)
PAG: PLES_43891(ldhA)
PPU: PP_1649(ldhA)
PPF: Pput_4068
PPG: PputGB1_1251
PPW: PputW619_1211
PFL: PFL_4452(ldhA)
PFO: Pfl01_4223
PFS: PFLU3778
PEN: PSEEN1358(ldhA)
PMY: Pmen_1729 Pmen_3636
PSA: PST_0207(ldhA)
CJA: CJA_1606
AVN: Avin_07010
PRW: PsycPRwf_1080
ACI: ACIAD0109(dld)
ACB: A1S_0070
ABM: ABSDF0088(dld)
ABY: ABAYE3796(dld)
ABC: ACICU_00096
ABN: AB57_0119
ABB: ABBFA_003442
SON: SO_0968(ldhA)
SDN: Sden_3047
SFR: Sfri_0518
SAZ: Sama_0612
SBL: Sbal_0858
SBM: Shew185_3506
SBN: Sbal195_3629
SBP: Sbal223_3434
SLO: Shew_0787
SPC: Sputcn32_0904
SSE: Ssed_0825
SPL: Spea_0742
SHE: Shewmr4_0807
SHM: Shewmr7_3216
SHN: Shewana3_3319
SHW: Sputw3181_3268
SHL: Shal_0795
SWD: Swoo_0923
SWP: swp_4333
PAT: Patl_2088
SDE: Sde_2866
MAQ: Maqu_3853
AMC: MADE_01443 MADE_01510 MADE_01901
PIN: Ping_0091
TTU: TERTU_1470 TERTU_3161
MCA: MCA0182
TCX: Tcr_1607
NOC: Noc_0352
TGR: Tgr7_0755
HNA: Hneap_0071 Hneap_0673 Hneap_2252
CSA: Csal_3144
MMW: Mmwyl1_2752 Mmwyl1_3029
AHA: AHA_4145
ASA: ASA_0168(ldhA)
TAU: Tola_1538
AFE: Lferr_0313 Lferr_2757
AFR: AFE_0140 AFE_3161
NMA: NMA1205(dld) NMA1944
NME: NMB0997(dld) NMB1685(ldhA)
NMC: NMC0984(dld) NMC1603(ldhA)
NMN: NMCC_0940(dld) NMCC_1598(ldhA)
NMI: NMO_0906(dld) NMO_1504(ldhA)
NGO: NGO0890 NGO1336
NGK: NGK_0915 NGK_1561
RSO: RSc3131(ldhA)
RPI: Rpic_3406
RPF: Rpic12D_3060
REU: Reut_B4140
REH: H16_A1681(ldhA1) H16_A1682(ldhA2)
CTI: RALTA_A1561(ldhA)
BMA: BMA2050(ldhA)
BMV: BMASAVP1_A0863(ldhA)
BML: BMA10229_A2695(ldhA)
BMN: BMA10247_1915(ldhA)
BPS: BPSL2734(ldhA)
BPM: BURPS1710b_3221
BPL: BURPS1106A_3207
BPD: BURPS668_3168
BPR: GBP346_A3348
BTE: BTH_I1402
BVI: Bcep1808_0762 Bcep1808_6274
BUR: Bcep18194_A3918
BCN: Bcen_0342
BCH: Bcen2424_0825
BCM: Bcenmc03_0795
BCJ: BCAL2487(dld) BCAL3179(ldhA)
BAM: Bamb_0705
BAC: BamMC406_0722
BMU: Bmul_2558
BMJ: BMULJ_00680(ldhA)
BXE: Bxe_A3894 Bxe_B2160
BPH: Bphy_2429
BPY: Bphyt_0787 Bphyt_2057
BPE: BP0651(dld)
BBR: BB4787(dld)
AJS: Ajs_2163 Ajs_2682
DAC: Daci_3347
NEU: NE0899(ldhA) NE1009
NET: Neut_1304 Neut_2388
NMU: Nmul_A0193
TBD: Tbd_1998
MFA: Mfla_0399
MMB: Mmol_0658
NIS: NIS_0056
NAM: NAMH_0636
MXA: MXAN_7165(ldhA)
HOH: Hoch_1800
MES: Meso_3888
ATU: Atu3870(ldhA)
ATC: AGR_L_1952
BME: BMEII0185
BMI: BMEA_B1063
BMF: BAB2_1073
BMC: BAbS19_II09980
BMT: BSUIS_B1109
BMR: BMI_II1115(dld)
RPB: RPB_2257
RPC: RPC_4634
MEX: Mext_0035 Mext_4349
MEA: Mex_1p4794(ldhA)
MDI: METDI5391(ldhA)
MCH: Mchl_1278 Mchl_4751
MNO: Mnod_3071
BID: Bind_3451
CAK: Caul_1358
PZU: PHZ_p0157(ldhA)
RSP: RSP_0407
RSH: Rsph17029_2061
RSQ: Rsph17025_2329
RSK: RSKD131_1738
RDE: RD1_0074(dld)
PDE: Pden_2928
HNE: HNE_1654(dld)
ZMO: ZMO0256 ZMO1237
ZMN: Za10_0094 Za10_0962
GOX: GOX1253
APT: APA01_20440
MGM: Mmc1_3296
SAU: SA2312(ddh) SA2346
SAV: SAV2524(ddh) SAV2559
SAW: SAHV_2508(ddh) SAHV_2543
SAM: MW2444(ddh) MW2480
SAR: SAR2605(ddh) SAR2640
SAS: SAS2410 SAS2445
SAC: SACOL2535 SACOL2574
SAB: SAB2398(ddh) SAB2432c
SAA: SAUSA300_2463(ddh) SAUSA300_2496
SAX: USA300HOU_2513(ddh) USA300HOU_2554
SAO: SAOUHSC_02830 SAOUHSC_02875
SAJ: SaurJH9_2547 SaurJH9_2581
SAH: SaurJH1_2599 SaurJH1_2635
SAE: NWMN_2422 NWMN_2459
SAD: SAAV_2589 SAAV_2625
SEP: SE2074 SE2121
SER: SERP2087 SERP2133
SHA: SH0493 SH0545(ddh)
SSP: SSP0295
SCA: Sca_2121(ddh)
MCL: MCCL_0071
LLC: LACR_C33
SPY: SPy_1170(ddh)
SPZ: M5005_Spy_0890(ddh)
SPH: MGAS10270_Spy1004(ddh)
SPI: MGAS10750_Spy1039(ddh)
SPJ: MGAS2096_Spy0963(ddh)
SPK: MGAS9429_Spy1007(ddh)
SPB: M28_Spy0863(ddh)
SOZ: Spy49_0919
SAG: SAG0695(ldhA)
SAN: gbs0668
SAK: SAK_0821(ldhA)
SDS: SDEG_1003(ddh)
LPL: lp_2057(ldhD)
LPJ: JDM1_0728 JDM1_1719(ldhD)
LJO: LJ0045
LJF: FI9785_110(ldhD)
LAC: LBA0055(ldhD)
LSL: LSL_0308(ldhA) LSL_1887(ldhD)
LDB: Ldb0101(ldhA) Ldb1010 Ldb2021
LBU: LBUL_0084 LBUL_0917 LBUL_1868
LBR: LVIS_0201 LVIS_1352
LCA: LSEI_0145 LSEI_2156
LCB: LCABL_01370(ldhD) LCABL_06520(dld) LCABL_23380(ldhA)
LGA: LGAS_0043
LRE: Lreu_0043 Lreu_0683 Lreu_1631 Lreu_1692
LRF: LAR_0040 LAR_0656 LAR_1523 LAR_1580
LHE: lhv_0064
LFE: LAF_0030 LAF_0632 LAF_1102 LAF_1770
LRH: LGG_00158(ldhD) LGG_02163(ldhA)
LRL: LC705_00155(ldhD) LC705_02167(ldhA)
PPE: PEPE_0876
EFA: EF2295
OOE: OEOE_0413 OEOE_1182 OEOE_1709
LME: LEUM_0373 LEUM_1756 LEUM_2043
LCI: LCK_00027(ddh) LCK_00222 LCK_00389(ldhD) LCK_00928
CAC: CAC1543 CAC2691
CPE: CPE0530(ldhD)
CPF: CPF_0510
CPR: CPR_0499(idhA)
CTC: CTC01840
CDF: CD0394(ldhA)
CDC: CD196_0379(ldhA)
CDL: CDR20291_0365(ldhA)
CBO: CBO3283(ldhA1) CBO3284(fldH)
CBA: CLB_3339(ldhA-1) CLB_3340(ldhA-2)
CBH: CLC_3225(ldhA-1) CLC_3226(ldhA-2)
CBY: CLM_3716(ldhA) CLM_3717(ldhA)
CBL: CLK_2699(ldhA) CLK_2700(ldhA)
CBB: CLD_1239(ldhA) CLD_1240(ldhA)
CBI: CLJ_B3563(ldhA_1) CLJ_B3564(ldhA_2)
CBT: CLH_2763
CBF: CLI_3453(ldhA-1) CLI_3454(ldhA-2)
CBE: Cbei_1506
CKL: CKL_2215
CKR: CKR_1949
CPY: Cphy_1923
EEL: EUBELI_00181
MPE: MYPE2650
MMY: MSC_0034(ldh)
MAA: MAG_1490(ldhD)
CGL: NCgl0865(cgl0901)
CGB: cg1027(dld)
SCO: SCO2118(dldh2) SCO3594(dldH)
SGR: SGR_5384
BFA: Bfae_05140
FRE: Franean1_7138
STP: Strop_2972
SAQ: Sare_3196
CAI: Caci_5794
APV: Apar_1039
TPA: TP0037
TPP: TPASS_0037
BHY: BHWA1_00747(ldhA)
BTH: BT_1575
BFR: BF1459
BFS: BF1389(ldhA)
BVU: BVU_2499
PDI: BDI_1057
CHU: CHU_2980(ldhA)
DFE: Dfer_1648
CPI: Cpin_5669
PHE: Phep_1678
FJO: Fjoh_1917
COC: Coch_1563
FNU: FN0487 FN0511
LBA: Lebu_0987
STR: Sterm_3357
SMF: Smon_0230
RBA: RB8859(ldhA)
EMI: Emin_1013
SYN: slr1556(ddh)
SYC: syc0206_d(ldhA)
SYF: Synpcc7942_1347
SYP: SYNPCC7002_G0164(ldhA)
TEL: tlr0711
CYT: cce_1601
CYP: PCC8801_2255
CYN: Cyan7425_2727
CYH: Cyan8802_2306
ANA: alr0058
NPU: Npun_F2517
AVA: Ava_2660
PMA: Pro1755(dld)
PMJ: P9211_13031
AMR: AM1_5122
RRS: RoseRS_4355
RCA: Rcas_0709
AAE: aq_1769(dld1) aq_727(ldhA)
HYA: HY04AAS1_0837
SUL: SYO3AOP1_0314
SAF: SULAZ_1655
PMX: PERMA_0506
Taxonomy
Structures PDB: 1F0X  1J49  1J4A  2DLD  3KB6  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13815938]
DENNIS D, KAPLAN NO.
D- and L-lactic acid dehydrogenases in Lactobacillus plantarum.
J. Biol. Chem. 235 (1960) 810-8.
Lactobacillus plantarum [GN:lpl]
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.28
IUBMB Enzyme Nomenclature: 1.1.1.28
ExPASy - ENZYME nomenclature database: 1.1.1.28
BRENDA, the Enzyme Database: 1.1.1.28
CAS: 9028-36-8
DBGET integrated database retrieval system