KEGG   ENZYME: 1.1.1.281Help
Entry
EC 1.1.1.281                Enzyme                                 
Name
GDP-4-dehydro-6-deoxy-D-mannose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous];
GDP-6-deoxy-D-lyxo-4-hexulose reductase;
Rmd;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming)
Reaction(IUBMB)
GDP-6-deoxy-alpha-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-alpha-D-mannose + NAD(P)H + H+ [RN:R03397 R03399]
Reaction(KEGG)
Substrate
GDP-6-deoxy-alpha-D-mannose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
GDP-4-dehydro-6-deoxy-alpha-D-mannose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-alpha-D-rhamnose (GDP-6-deoxy-alpha-D-mannose). D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria.
Pathway
Fructose and mannose metabolism
Amino sugar and nucleotide sugar metabolism
Orthology
K15856  
GDP-4-dehydro-6-deoxy-D-mannose reductase
Reference
1  [PMID:11096116]
  Authors
Kneidinger B, Graninger M, Adam G, Puchberger M, Kosma P, Zayni S, Messner P.
  Title
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T.
  Journal
J. Biol. Chem. 276 (2001) 5577-83.
  Organism
Aneurinibacillus thermoaerophilus
Reference
2  [PMID:11856318]
  Authors
Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R.
  Title
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose.
  Journal
Eur. J. Biochem. 269 (2002) 593-601.
  Organism
Pseudomonas aeruginosa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
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