KEGG   ENZYME: 1.1.1.289Help
Entry
EC 1.1.1.289                Enzyme                                 

Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Orthology
K17742  
sorbose reductase
Genes
KLA: 
LTH: 
ZRO: 
TDL: 
TDEL_0B02360(TDEL0B02360) TDEL_0H04540(TDEL0H04540)
PPA: 
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
YLI: 
CLU: 
 » show all
Taxonomy
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E.
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast. 22 (2005) 957-69.
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22 (2005) 1171.
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric. Biol. Chem. 55 (1991) 2043-2049.
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T.
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J. Bacteriol. 184 (2002) 861-3.
  Sequence
[up:Q8VUU5] [goh:B932_1684]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
138440-90-1

DBGET integrated database retrieval system