KEGG   ENZYME: 1.1.1.30Help
Entry
EC 1.1.1.30                 Enzyme                                 
Name 3-hydroxybutyrate dehydrogenase;
NAD-beta-hydroxybutyrate dehydrogenase;
hydroxybutyrate oxidoreductase;
beta-hydroxybutyrate dehydrogenase;
D-beta-hydroxybutyrate dehydrogenase;
D-3-hydroxybutyrate dehydrogenase;
D-(-)-3-hydroxybutyrate dehydrogenase;
beta-hydroxybutyric acid dehydrogenase;
3-D-hydroxybutyrate dehydrogenase;
beta-hydroxybutyric dehydrogenase
Class Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname (R)-3-hydroxybutanoate:NAD+ oxidoreductase
Reaction(IUBMB) (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+ [RN:R01361]
Reaction(KEGG) R01361
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Substrate (R)-3-hydroxybutanoate [CPD:C01089];
NAD+ [CPD:C00003]
Product acetoacetate [CPD:C00164];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment Also oxidizes other 3-hydroxymonocarboxylic acids.
Pathway PATH: ec00072  Synthesis and degradation of ketone bodies
PATH: ec00650  Butanoate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00019  3-hydroxybutyrate dehydrogenase
Genes HSA: 56898(BDH2) 622(BDH1)
PTR: 460970(BDH1) 462895
MCC: 711108
MMU: 69772(Bdh2) 71911(Bdh1)
RNO: 117099(Bdh1) 295458(Bdh2)
CFA: 488037(BDH1)
BTA: 515321(BDH2) 534090(BDH1)
ECB: 100069438
MDO: 100012027 100032119
OAA: 100082234
GGA: 424891(BDH1)
TGU: 100220657 100225954
DRE: 100037356 550507
DME: Dmel_CG12068 Dmel_CG13377
AFM: AFUA_5G09290
DDI: DDBDRAFT_0184469
TET: TTHERM_00039050 TTHERM_01005260
TBR: Tb10.389.1850
TCR: 506567.70 507049.60
ECW: EcE24377A_1665(bdhA)
ECR: ECIAI1_1486
KPN: KPN_02057
KPE: KPK_2273(bdhA)
KPU: KP1_3134
SPE: Spro_0595
HSM: HSM_0811
XCC: XCC2162(hbdH1)
XCB: XC_1956
XCV: XCV2206(bdhA)
XAC: XAC2045(hbdH1)
XOO: XOO2218(hbdH1)
XOM: XOO_2083
SML: Smlt2084
SMT: Smal_1682
PAE: PA2003(bdhA)
PAU: PA14_38590(bdhA)
PAP: PSPA7_3286(bdhA)
PAG: PLES_33201(bdhA)
PPU: PP_3073(bdhA)
PPF: Pput_2651
PPG: PputGB1_2793
PPW: PputW619_2718
PFL: PFL_3576
PFO: Pfl01_3079
PFS: PFLU2628
PEN: PSEEN3158(bdhA)
PMY: Pmen_4355
PSA: PST_0861
AVN: Avin_17590
PAR: Psyc_1428
PCR: Pcryo_1592
PRW: PsycPRwf_1704
ACI: ACIAD2509(bdhA)
ACB: A1S_1737
ABY: ABAYE1909(bdhA)
ABC: ACICU_01774
ABN: AB57_1967
ABB: ABBFA_001757
SAZ: Sama_0517
SHN: Shewana3_3466
CPS: CPS_0943(bdhA1) CPS_4091(bdhA2)
PHA: PSHAa2944(bdhA)
PAT: Patl_1976
SDE: Sde_1324
MAQ: Maqu_0088
LPN: lpg2316(bdhA)
LPF: lpl2236
LPP: lpp2264
LPC: LPC_1783(bdhA)
FTL: FTL_1281
CSA: Csal_1825
ABO: ABO_1479
CVI: CV_0695(bdhA)
RSO: RS02396(RSp1059) RSc1572
RPI: Rpic_1981 Rpic_4270
RPF: Rpic12D_1651 Rpic12D_4380
REU: Reut_A1271 Reut_B3729
REH: H16_A1334 H16_A1814
RME: Rmet_0546 Rmet_1156
CTI: RALTA_A1256
BMA: BMAA0017(bdhA-1) BMAA0876(bdhA-2)
BMV: BMASAVP1_1167(bdhA-1)
BML: BMA10229_0018(bdhA-2) BMA10229_1447(bdhA-1)
BMN: BMA10247_A0021(bdhA-1) BMA10247_A0918(bdhA-2)
BPS: BPSS0017 BPSS0354
BPM: BURPS1710b_A1524(bdhA-1) BURPS1710b_A1918(bdhA-2)
BPL: BURPS1106A_A0021(bdhA) BURPS1106A_A0505(bdhA)
BPD: BURPS668_A0023(bdhA) BURPS668_A0602(bdhA)
BTE: BTH_II0019 BTH_II2038
BVI: Bcep1808_2297 Bcep1808_3778
BUR: Bcep18194_A5540 Bcep18194_B3167
BCN: Bcen_5146 Bcen_5865
BCH: Bcen2424_2212 Bcen2424_5713
BCM: Bcenmc03_2236
BAM: Bamb_2250 Bamb_4982
BXE: Bxe_A3156 Bxe_B0969
PNU: Pnuc_1386
PNE: Pnec_0575
BPE: BP0229 BP2454
BPA: BPP3441 BPP3638
BBR: BB3891 BB4073
BPT: Bpet1600
BAV: BAV2676(hbdH)
RFR: Rfer_2069 Rfer_3285
POL: Bpro_2705
PNA: Pnap_2539
AAV: Aave_1586
AJS: Ajs_3151
VEI: Veis_4364
DAC: Daci_2854
DIA: Dtpsy_2498
VAP: Vapar_2585
MPT: Mpe_A1576
HAR: HEAR1805(bdhA)
MMS: mma_1483(bdh)
LCH: Lcho_1897
EBA: ebA5833
ADE: Adeh_2140
ACP: A2cp1_1817
AFW: Anae109_1674
RFE: RF_1389 RF_1390
RBE: RBE_1385
MLO: mll3632 mlr2400
MES: Meso_3335
SME: SM_b21010(bdhA)
SMD: Smed_4500
ATU: Atu2308(bdhA) Atu4131
ATC: AGR_C_4198 AGR_L_1444
ARA: Arad_3311(bdhA)
AVI: Avi_3319(bdhA)
RET: RHE_CH03123(bdhA)
REC: RHECIAT_CH0003282(bdhA)
RLE: RL3569(bdhA) pRL90175(bdhA)
RLT: Rleg2_2860
RLG: Rleg_3132
RHI: NGR_b05400(bdhA1) NGR_c23850(bdhA2)
BME: BMEI0268 BMEII1090
BMF: BAB1_1789
BMB: BruAb1_1762
BMC: BAbS19_I16720
BMS: BR1779
BMT: BSUIS_B1255
BCS: BCAN_A1817
BMR: BMI_I1797
OAN: Oant_1122
BJA: blr1488(bdhA) blr7029(bdhA)
BRA: BRADO1076
BBT: BBta_6971
RPA: RPA4206
RPB: RPB_1408
RPC: RPC_1997 RPC_2000 RPC_4002
RPD: RPD_1388
RPE: RPE_1773
RPT: Rpal_4687
NWI: Nwi_2755
NHA: Nham_3554
OCA: OCAR_7381
XAU: Xaut_1887
AZC: AZC_4577
MEX: Mext_4730
MEA: Mex_1p5182(hbd)
MDI: METDI5783(hbd)
MRD: Mrad2831_3482
MET: M446_4798
MPO: Mpop_5269
MCH: Mchl_5197
MNO: Mnod_4591 Mnod_8088
BID: Bind_2696 Bind_3009
MSL: Msil_0811
CCR: CC_3384
CCS: CCNA_03495
CAK: Caul_4481
PZU: PHZ_c0562
SIL: SPO1015 SPO2065(bdh-1)
SIT: TM1040_1342 TM1040_3270
RSP: RSP_2857
RSH: Rsph17029_1436
RSQ: Rsph17025_1507
RSK: RSKD131_1100
JAN: Jann_2311
RDE: RD1_2738(bdhA)
PDE: Pden_0932
DSH: Dshi_1544
MMR: Mmar10_0826
HNE: HNE_0125(bdhA)
NAR: Saro_1750
SAL: Sala_0938
SWI: Swit_3432
ELI: ELI_07105
ACR: Acry_0494 Acry_2355
RRU: Rru_A1057
RCE: RC1_1846(bdhA)
MAG: amb2677
BSU: BSU38970(yxjF)
BAN: BA4249
BAR: GBAA4249
BAA: BA_4708
BAT: BAS3941
BAH: BAMEG_4288
BCE: BC4030
BCA: BCE_4084
BCZ: BCZK3788
BCR: BCAH187_A4157
BCB: BCB4264_A4137
BCU: BCAH820_4051
BCG: BCG9842_B1101
BCQ: BCQ_3820
BCX: BCA_4141
BCY: Bcer98_2729
BTK: BT9727_3773
BTL: BALH_3648
BWE: BcerKBAB4_3859
BCL: ABC3434(bdh)
BAY: RBAM_037840(yxjF1)
OIH: OB2631
GKA: GK1983
GTN: GTNG_1881
SSP: SSP2198
ESI: Exig_1174
EAT: EAT1b_0231
BBE: BBR47_03510(yxjF)
AAC: Aaci_0240
SPY: SPy_1640
SPZ: M5005_Spy_1347
SPM: spyM18_1649
SPG: SpyM3_1381 SpyM3_1382
SPS: SPs0480 SPs0481
SPH: MGAS10270_Spy1464
SPI: MGAS10750_Spy1456
SPJ: MGAS2096_Spy1368
SPK: MGAS9429_Spy1342
SPF: SpyM50444
SPA: M6_Spy1393
SPB: M28_Spy1388
SEZ: Sez_1434
CDF: CD2679(bdhA)
MSM: MSMEG_6026
MVA: Mvan_5299
MGI: Mflv_1472
MMC: Mmcs_4701
MKM: Mkms_4787
MJL: Mjls_5086
CGT: cgR_2407
CEF: CE2393
NFA: nfa28660
RHA: RHA1_ro04778
SCO: SCO1012(2SCG2.25c)
SMA: SAV_1420(bdhA)
SGR: SGR_1195
ART: Arth_0366
AAU: AAur_0392(bdh)
RSA: RSal33209_3111
KRH: KRH_02330(bdh)
TFU: Tfu_0081
SEN: SACE_3718 SACE_6685
STP: Strop_1807
SAQ: Sare_1797
RXY: Rxyl_2343
CAU: Caur_2956
DGE: Dgeo_0952
TTH: TTC0333
TTJ: TTHA0693
HMA: rrnAC0648(bdhA)
NPH: NP6040A
Taxonomy
Structures PDB: 1WMB  1X1T  2Q2Q  2Q2V  2Q2W  2YZ7  2ZEA  2ZTL  2ZTM  2ZTU  
     2ZTV  3EEW  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4291491]
Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH.
Purification and properties of crystalline 3-hydroxybutyrate
dehydrogenase from Rhodopseudomonas spheroides.
Biochem. J. 102 (1967) 423-31.
Rhodopseudomonas spheroides
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4954074]
Delafield FP, Cooksey KE, Doudoroff M.
beta-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas
lemoignei.
J. Biol. Chem. 240 (1965) 4023-8.
Pseudomonas lemoignei
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:14415394]
LEHNINGER AL, SUDDUTH HC, WISE JB.
D-beta-Hydroxybutyric dehydrogenase of muitochondria.
J. Biol. Chem. 235 (1960) 2450-5.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 1.1.1.30
IUBMB Enzyme Nomenclature: 1.1.1.30
ExPASy - ENZYME nomenclature database: 1.1.1.30
BRENDA, the Enzyme Database: 1.1.1.30
CAS: 9028-38-0
DBGET integrated database retrieval system