| Entry |
|
|---|
| Name |
NADP-retinol dehydrogenase;
all-trans retinal reductase;
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
retinol:NADP+ oxidoreductase
|
|---|
| Reaction(IUBMB) |
retinol + NADP+ = retinal + NADPH + H+ [RN: R08379]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.14.99.36 (beta-carotene 15,15'-monooxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
|
|---|
| Reference |
|
|---|
| Authors |
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY |
|---|
| Title |
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids. |
|---|
| Journal |
Biochemistry. 44 (2005) 7035-47. |
|---|
| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY |
|---|
| Title |
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity. |
|---|
| Journal |
FEBS. J. 275 (2008) 138-47. |
|---|
| Organism |
|
|---|
| Reference |
|
|---|
| Authors |
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K |
|---|
| Title |
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. |
|---|
| Journal |
J. Biol. Chem. 273 (1998) 21790-9. |
|---|
| Organism |
Homo sapiens [GN: hsa], Mus musculus [GN: mmu], Bos taurus [GN: bta] |
|---|
| Reference |
|
|---|
| Authors |
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS |
|---|
| Title |
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1). |
|---|
| Journal |
J. Biol. Chem. 277 (2002) 28909-15. |
|---|
| Organism |
|
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
|---|
