KEGG   ENZYME: 1.1.1.300Help
Entry
EC 1.1.1.300                Enzyme                                 

Name
NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinol:NADP+ oxidoreductase
Reaction(IUBMB)
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
Reaction(KEGG)
Substrate
retinol [CPD:C00473];
NADP+ [CPD:C00006]
Product
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.14.99.36 (beta-carotene 15,15'-monooxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
History
EC 1.1.1.300 created 2009
Orthology
K11146  
short-chain dehydrogenase/reductase 3
K11152  
retinol dehydrogenase 11
K11153  
retinol dehydrogenase 12
K11161  
retinol dehydrogenase 13
Genes
HSA: 
112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 
100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 
100971367(DHRS3) 100974938 100976717(RDH12) 100995016(RDH13)
GGO: 
101132424(RDH13) 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 
MCC: 
711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798
MCF: 
101865597 101866088(ARSDR1) 102118061(RDH13) 102142015(DHRS3)
MMU: 
108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
RNO: 
313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
CGE: 
100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
HGL: 
101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
TUP: 
102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3)
CFA: 
480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
AML: 
FCA: 
101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 
102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
BTA: 
281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 
102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
PHD: 
102321429(RDH12) 102322389(RDH11) 102323197(DHRS3) 102329922(RDH13)
CHX: 
102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 
101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882(RDH13)
SSC: 
100153020(RDH12) 100154684(RDH11) 100514967(DHRS3)
CFR: 
102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
BACU: 
103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 
103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
ECB: 
100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
MYB: 
102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 
102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
PALE: 
102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
MDO: 
100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
SHR: 
100913855(DHRS3) 100923639(RDH11) 100923904(RDH12) 100931844
OAA: 
GGA: 
419480(DHRS3) 423274(RDH12)
MGP: 
TGU: 
100221618(DHRS3) 100226769(RDH12)
FAB: 
101814379(DHRS3) 101816060(RDH12)
PHI: 
102106104(RDH12) 102110985(DHRS3)
APLA: 
101792259(DHRS3) 101793409(RDH12)
FPG: 
101916630(RDH12) 101921484(DHRS3)
FCH: 
102055890(RDH12) 102058887(DHRS3)
CLV: 
ASN: 
102370531(DHRS3) 102373718(RDH12)
AMJ: 
102567292(RDH12) 102574201(DHRS3)
PSS: 
102445977(DHRS3) 102446647(RDH12)
CMY: 
102934533(RDH12) 102944040(DHRS3)
ACS: 
PBI: 
103054360(DHRS3)
XLA: 
444106(rdh13) 444269(dhrs3)
XTR: 
493258(dhrs3) 496409(rdh13)
DRE: 
436597(rdh12) 450050(dhrs3b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103175207(rdh12) 103179224(rdh13)
BFO: 
SPU: 
ISC: 
AQU: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:15865448]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
  Title
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
  Journal
Biochemistry. 44 (2005) 7035-47.
  Sequence
[hsa:145226]
Reference
2  [PMID:18039331]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
  Title
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
  Journal
FEBS. J. 275 (2008) 138-47.
  Sequence
[hsa:112724]
Reference
3  [PMID:9705317]
  Authors
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
  Title
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
  Journal
J. Biol. Chem. 273 (1998) 21790-9.
  Sequence
[hsa:9249] [mmu:20148] [bta:281482]
Reference
4  [PMID:12036956]
  Authors
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
  Title
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
  Journal
J. Biol. Chem. 277 (2002) 28909-15.
  Sequence
[hsa:51109]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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