KEGG   ENZYME: 1.1.1.307Help
Entry
EC 1.1.1.307                Enzyme                                 

Name
D-xylose reductase;
XylR;
XyrA;
msXR;
dsXR;
monospecific xylose reductase;
dual specific xylose reductase;
NAD(P)H-dependent xylose reductase;
xylose reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
xylitol:NAD(P)+ oxidoreductase
Reaction(IUBMB)
xylitol + NAD(P)+ = D-xylose + NAD(P)H + H+ [RN:R01431 R09477]
Reaction(KEGG)
Substrate
xylitol [CPD:C00379];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
D-xylose [CPD:C00181];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Xylose reductase catalyses the initial reaction in the xylose utilization pathway, the NAD(P)H dependent reduction of xylose to xylitol.
History
EC 1.1.1.307 created 2010
Pathway
Pentose and glucuronate interconversions
Metabolic pathways
Orthology
K17743  
D-xylose reductase
Genes
CIC: 
MIS: 
CCP: 
SCE: 
YHR104W(GRE3)
AGO: 
ERC: 
KLA: 
LTH: 
ZRO: 
CGR: 
NCS: 
NCAS_0A06660(NCAS0A06660)
NDI: 
NDAI_0D01600(NDAI0D01600)
TPF: 
TPHA_0E01860(TPHA0E01860)
TBL: 
TBLA_0A00630(TBLA0A00630) TBLA_0F01720(TBLA0F01720)
TDL: 
TDEL_0E02150(TDEL0E02150)
KAF: 
KAFR_0C05320(KAFR0C05320)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAJ: 
VAL: 
ELA: 
SSL: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1522154(AO090003000859)
ANG: 
ANI_1_2444014(An01g03740)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
MRR: 
CCI: 
SCM: 
CPUT: 
SLA: 
EHX: 
AMAC: 
AMB: 
AMG: 
ALT: 
AAL: 
PBS: 
SACI: 
 » show all
Taxonomy
Reference
1  [PMID:9307017]
  Authors
Neuhauser W, Haltrich D, Kulbe KD, Nidetzky B
  Title
NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme.
  Journal
Biochem. J. 326 ( Pt 3) (1997) 683-92.
Reference
2  [PMID:14690376]
  Authors
Nidetzky B, Bruggler K, Kratzer R, Mayr P
  Title
Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies.
  Journal
J. Agric. Food. Chem. 51 (2003) 7930-5.
Reference
3  [PMID:14526534]
  Authors
Iablochkova EN, Bolotnikova OI, Mikhailova NP, Nemova NN, Ginak AI
  Title
[The activity of xylose reductase and xylitol dehydrogenase in yeasts]
  Journal
Mikrobiologiia. 72 (2003) 466-9.
Reference
4  [PMID:19342796]
  Authors
Chen LC, Huang SC, Chuankhayan P, Chen CD, Huang YC, Jeyakanthan J, Pang HF, Men LC, Chen YC, Wang YK, Liu MY, Wu TK, Chen CJ
  Title
Purification, crystallization and preliminary X-ray crystallographic analysis of  xylose reductase from Candida tropicalis.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 65 (2009) 419-21.
Reference
5  [PMID:3921014]
  Authors
Verduyn C, Van Kleef R, Frank J, Schreuder H, Van Dijken JP, Scheffers WA
  Title
Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis.
  Journal
Biochem. J. 226 (1985) 669-77.
  Sequence
[up:P31867]
Reference
6  [PMID:20093741]
  Authors
Fernandes S, Tuohy MG, Murray PG
  Title
Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and  heterologous expression of the native gene (Texr) and a double mutant (TexrK271R  + N273D) with altered coenzyme specificity.
  Journal
J. Biosci. 34 (2009) 881-90.
Reference
7  [PMID:14532079]
  Authors
Lee JK, Koo BS, Kim SY
  Title
Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis.
  Journal
Appl. Environ. Microbiol. 69 (2003) 6179-88.
  Sequence
[up:Q6Y0Z3]
Reference
8  [PMID:15746370]
  Authors
Woodyer R, Simurdiak M, van der Donk WA, Zhao H
  Title
Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa.
  Journal
Appl. Environ. Microbiol. 71 (2005) 1642-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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